Non-Targeted Metabolomics Approach Revealed Significant Changes in Metabolic Pathways in Patients with Chronic Traumatic Encephalopathy

• Published in: Biomedicines Vol. 10; no. 7; p. 1718
• Main Authors: Lee, Jinkyung, Kim, Suhyun, Kim, Yoon Hwan, Park, Uiyeol, Lee, Junghee, McKee, Ann C., Kim, Kyoung Heon, Ryu, Hoon, Lee, Jeongae
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 15.07.2022; MDPI
• Subjects: Acids; Alzheimer's disease; astrocyte activation; Autopsy; catecholamines; Chronic traumatic encephalopathy; chronic traumatic encephalopathy (CTE); Cognitive ability; Dementia; Discriminant analysis; Head injuries; High-performance liquid chromatography; Inflammation; Mass spectroscopy; Metabolic pathways; Metabolism; Metabolites; Metabolomics; Neurodegenerative diseases; non-targeted metabolomics; Patients; Phenylalanine; phenylalanine metabolism; Software; Solvents; Systems stability; Trauma; Traumatic brain injury; Tyrosine; tyrosine metabolism; United States > US; Germany

Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease that is frequently found in athletes and those who have experienced repetitive head traumas. CTE is associated with a variety of neuropathologies, which cause cognitive and behavioral impairments in CTE patients. However, currentl...