Potential therapeutic targets for combating SARS-CoV-2: Drug repurposing, clinical trials and recent advancements

• Published in: Life sciences (1973) Vol. 256; p. 117883
• Main Authors: Pandey, Abhjieet, Nikam, Ajinkya Nitin, Shreya, Ajjappla Basavaraj, Mutalik, Sadhana P., Gopalan, Divya, Kulkarni, Sanjay, Padya, Bharath Singh, Fernandes, Gasper, Mutalik, Srinivas, Prassl, Ruth
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.09.2020; Elsevier BV
• Subjects: Aminoquinolines - therapeutic use; Anti-Bacterial Agents - therapeutic use; Antibiotics; Antiviral agents; Antiviral Agents - therapeutic use; Betacoronavirus - isolation & purification; Case studies; Clinical trials; Complications; Coronavirus Infections - drug therapy; Coronavirus Infections - prevention & control; Coronavirus Infections - virology; COVID-19; COVID-19 Vaccines; DNA-directed RNA polymerase; Drug development; Drug Repositioning; Epidemiology; Genotypes; Humans; Metal ions; Pandemics; Phenotypes; Pneumonia, Viral - drug therapy; Pneumonia, Viral - virology; Quinolones; RNA polymerase; SARS-CoV-2; Severe acute respiratory syndrome; Severe acute respiratory syndrome coronavirus 2; Therapeutic applications; Therapeutic targets; Vaccines; Viral Vaccines - administration & dosage

The present pandemic of SARS-CoV-2 has been a tough task for the whole world to deal with. With the absence of specific drugs or vaccines against SARS-CoV-2, the situation is very difficult to control. Apart from the absence of specific therapies, the lack of knowledge about potential therapeutic ta...