Glucose-Dependent Insulinotropic Polypeptide Stimulates Osteopontin Expression in the Vasculature via Endothelin-1 and CREB

• Published in: Diabetes (New York, N.Y.) Vol. 65; no. 1; pp. 239 - 254
• Main Authors: Berglund, Lisa M., Lyssenko, Valeriya, Ladenvall, Claes, Kotova, Olga, Edsfeldt, Andreas, Pilgaard, Kasper, Alkayyali, Sami, Brøns, Charlotte, Forsblom, Carol, Jonsson, Anna, Zetterqvist, Anna V., Nitulescu, Mihaela, McDavitt, Christian Ruiz, Dunér, Pontus, Stancáková, Alena, Kuusisto, Johanna, Ahlqvist, Emma, Lajer, Maria, Tarnow, Lise, Madsbad, Sten, Rossing, Peter, Kieffer, Timothy J., Melander, Olle, Orho-Melander, Marju, Nilsson, Peter, Groop, Per-Henrik, Vaag, Allan, Lindblad, Bengt, Gottsäter, Anders, Laakso, Markku, Goncalves, Isabel, Groop, Leif, Gomez, Maria F.
• Format: Journal Article
• Language: English
• Published: United States 01.01.2016
• Subjects: Aged; Aged, 80 and over; Animals; Aorta - cytology; Blotting, Western; Cardiovascular Diseases - genetics; Carotid Arteries - cytology; Case-Control Studies; Clinical Medicine; Coronary Vessels - cytology; Cyclic AMP Response Element-Binding Protein - metabolism; Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - genetics; Diabetes Mellitus, Type 2 - metabolism; Endocrinology and Diabetes; Endokrinologi och diabetes; Endothelial Cells - metabolism; Endothelin-1 - genetics; Endothelin-1 - metabolism; Enzyme-Linked Immunosorbent Assay; Female; Fluorescent Antibody Technique; Gastric Inhibitory Polypeptide - metabolism; Humans; Immunohistochemistry; Klinisk medicin; Male; Medical and Health Sciences; Medicin och hälsovetenskap; Mice; Mice, Knockout; Microscopy, Confocal; Microvessels - cytology; Middle Aged; Myocytes, Smooth Muscle - metabolism; Osteopontin - genetics; Osteopontin - metabolism; Peripheral Arterial Disease - metabolism; Plaque, Atherosclerotic - metabolism; Polymorphism, Single Nucleotide; Rats; Rats, Inbred WKY; Real-Time Polymerase Chain Reaction; Receptors, Gastrointestinal Hormone - genetics; RNA, Messenger - metabolism; Stroke - complications; Stroke - genetics; Stroke - metabolism; Sus scrofa; Swine

Glucose-dependent insulinotropic polypeptide (GIP) is an incretin hormone with extrapancreatic effects beyond glycemic control. Here we demonstrate unexpected effects of GIP signaling in the vasculature. GIP induces the expression of the proatherogenic cytokine osteopontin (OPN) in mouse arteries vi...