Hydroxycitric acid reconstructs damaged articular cartilages by modifying the metabolic cascade in chondrogenic cells

• Published in: Osteoarthritis and cartilage open Vol. 7; no. 1; p. 100564
• Main Authors: Mizushina, Yoshiyuki, Sun, Liping, Nishio, Megumi, Nagata, Sanae, Kamakura, Takeshi, Fukuda, Masayuki, Tanaka, Kousuke, Toguchida, Junya, Jin, Yonghui
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.03.2025; Elsevier
• Subjects: ATP citrate lyase; Chondrogenesis; Hydroxycitric acid; Mitochondria; ORIGINAL PAPER; Osteoarthritis; β-catenin; ATP citrate lyase; DM-α-KG; OXPHOS; FCCP; WB; TMRE; FGF2; ActA; β-catenin; iPSCs; ACAN; LC-MS/MS; Mitochondria; OA; CPII; C2C; α-KG; FBS; Ac-CoA; Hydroxycitric acid; Chondrogenesis; RT-qPCR; Hyp; CP4H; PBS; 2D-CI; TSA; BM-MSCs; HCA; IP; 3D-CI; GAG; EDTA; ECAR; BMPs; ACLY; COL2A1; iMSCs; TGFβ; Osteoarthritis; HE; PN; dsDNA; OCR

Osteoarthritis, a degenerative joint disease, requires innovative therapies due to the limited ability of cartilage to regenerate. Since mesenchymal stem cells (MSCs) provide a cell source for chondrogenic cells, we hypothesize that chemicals capable of enhancing the chondrogenic potential of MSCs w...