Association of Killer Cell Immunoglobulin-like Receptor (KIR) Genes and their HLA Ligands with Susceptibility to Takayasu Arteritis in the Iranian Population

• Published in: Iranian journal of allergy, asthma, and immunology Vol. 22; no. 1; p. 25
• Main Authors: Beigmohammadi, Fereshteh, Aslani, Saeed, Kavosi, Hoda, Javinani, Ali, Mostafaei, Shayan, Pournazari, Mehran, Tasorian, Baharak, Farhadi, Elham, Hajiabbasi, Asghar, Zayeni, Habib, Khabbazi, Alireza, Jamshidi, Ahmadreza, Shenavar Masooleh, Irandokht, Tamartash, Zahra, Vojdanian, Mahdi, Mahmoudi, Mahdi
• Format: Journal Article
• Language: English
• Published: Iran Tehran University of Medical Sciences 01.02.2023
• Subjects: Aorta; Arteritis; Case-Control Studies; Cytotoxicity; Fibrosis; Gene Frequency; Gene polymorphism; Genetic association; Genotype; Histocompatibility antigen HLA; Humans; Immunoglobulin-like receptors; Immunoglobulins; Inflammatory diseases; Iran - epidemiology; Killer cell immunoglobulin-like receptor; Killer cell immunoglobulin-like receptors; KIR2DS4 protein; Ligands; Natural killer cell; Natural killer cells; Peripheral blood; Polymerase chain reaction; Potassium channels (inwardly-rectifying); Receptors, KIR - genetics; Takayasu arteritis; Takayasu Arteritis - genetics; Takayasu's disease; Vein & artery diseases; Iran; Natural killer cell; Takayasu arteritis; Genetic association; Killer cell immunoglobulin-like receptor

Takayasu arteritis (TA) is a chronic inflammatory disorder characterized by vascular damage and fibrosis in the intima that commonly occurs in the aorta. In many damaged sites in TA patients, natural killer (NK) cells have been shown to be hyperactivated and produce inflammatory cytokines and toxic...