The primary defect in experimental ileitis originates from a nonhematopoietic source
The initiating etiologic factor in Crohn's disease (CD) remains unclear. SAMP1/YitFc (SAMP) mice develop chronic ileitis similar to human CD. We used bone marrow chimeras to determine if SAMP ileitis results from a primary immunological defect or from dysregulated mucosal immunity secondary to...
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Published in | The Journal of experimental medicine Vol. 203; no. 3; pp. 541 - 552 |
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Main Authors | , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
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United States
The Rockefeller University Press
20.03.2006
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Abstract | The initiating etiologic factor in Crohn's disease (CD) remains unclear. SAMP1/YitFc (SAMP) mice develop chronic ileitis similar to human CD. We used bone marrow chimeras to determine if SAMP ileitis results from a primary immunological defect or from dysregulated mucosal immunity secondary to intrinsic, nonhematopoietic (e.g., epithelial) dysfunction. SAMP mice receiving wild-type (AKR) BM developed severe ileitis, whereas SAMP BM did not confer ileitis to WT recipients. WT lymphocytes from reconstituted SAMP mice resembled native SAMP populations in regard to surface phenotype and cytokine production. Ilea from native SAMP mice and SAMP recipients of wild-type BM displayed decreased epithelial barrier resistance ex vivo and increased epithelial permeability in vivo compared to native WT mice and AKR recipients of SAMP BM. This permeability defect preceded the development of ileal inflammation, was present in the absence of commensal bacteria, and was accompanied by altered ileal mRNA expression of the tight junction proteins claudin-2 and occludin. Our results provide evidence that the primary defect conferring ileitis in SAMP mice originates from a nonhematopoietic source. Generation of pathogenic lymphocytes is a consequence of this defect and does not reflect intrinsic proinflammatory leukocyte properties. Decreased barrier function suggests that defects in the epithelium may represent the primary source of SAMP ileitis susceptibility. |
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AbstractList | The initiating etiologic factor in Crohn's disease (CD) remains unclear. SAMP1/YitFc (SAMP) mice develop chronic ileitis similar to human CD. We used bone marrow chimeras to determine if SAMP ileitis results from a primary immunological defect or from dysregulated mucosal immunity secondary to intrinsic, nonhematopoietic (e.g., epithelial) dysfunction. SAMP mice receiving wild-type (AKR) BM developed severe ileitis, whereas SAMP BM did not confer ileitis to WT recipients. WT lymphocytes from reconstituted SAMP mice resembled native SAMP populations in regard to surface phenotype and cytokine production. Ilea from native SAMP mice and SAMP recipients of wild-type BM displayed decreased epithelial barrier resistance ex vivo and increased epithelial permeability in vivo compared to native WT mice and AKR recipients of SAMP BM. This permeability defect preceded the development of ileal inflammation, was present in the absence of commensal bacteria, and was accompanied by altered ileal mRNA expression of the tight junction proteins claudin-2 and occludin. Our results provide evidence that the primary defect conferring ileitis in SAMP mice originates from a nonhematopoietic source. Generation of pathogenic lymphocytes is a consequence of this defect and does not reflect intrinsic proinflammatory leukocyte properties. Decreased barrier function suggests that defects in the epithelium may represent the primary source of SAMP ileitis susceptibility. |
Author | Reuter, Brian K Morris, Margaret A Ernst, Peter B Wang, Xiao-Ming Burcin, Tracy L Olson, Timothy S Meddings, Jonathan B Ley, Klaus Hancock, Leslie N Cominelli, Fabio Pizarro, Theresa T Scott, Kevin G-E Cohn, Steven M |
AuthorAffiliation | 1 Department of Molecular Physiology, 2 Digestive Health Center of Excellence, 3 Robert M. Berne Cardiovascular Research Center, and 4 Department of Biomedical Engineering, University of Virginia Health System, Charlottesville, VA 22908 5 Department of Medicine, University of Alberta, Edmonton, AB, Canada T6G 2B7 |
AuthorAffiliation_xml | – name: 1 Department of Molecular Physiology, 2 Digestive Health Center of Excellence, 3 Robert M. Berne Cardiovascular Research Center, and 4 Department of Biomedical Engineering, University of Virginia Health System, Charlottesville, VA 22908 5 Department of Medicine, University of Alberta, Edmonton, AB, Canada T6G 2B7 |
Author_xml | – sequence: 1 givenname: Timothy S surname: Olson fullname: Olson, Timothy S organization: Department of Molecular Physiology, University of Virginia Health System, Charlottesville, VA 22908, USA – sequence: 2 givenname: Brian K surname: Reuter fullname: Reuter, Brian K – sequence: 3 givenname: Kevin G-E surname: Scott fullname: Scott, Kevin G-E – sequence: 4 givenname: Margaret A surname: Morris fullname: Morris, Margaret A – sequence: 5 givenname: Xiao-Ming surname: Wang fullname: Wang, Xiao-Ming – sequence: 6 givenname: Leslie N surname: Hancock fullname: Hancock, Leslie N – sequence: 7 givenname: Tracy L surname: Burcin fullname: Burcin, Tracy L – sequence: 8 givenname: Steven M surname: Cohn fullname: Cohn, Steven M – sequence: 9 givenname: Peter B surname: Ernst fullname: Ernst, Peter B – sequence: 10 givenname: Fabio surname: Cominelli fullname: Cominelli, Fabio – sequence: 11 givenname: Jonathan B surname: Meddings fullname: Meddings, Jonathan B – sequence: 12 givenname: Klaus surname: Ley fullname: Ley, Klaus – sequence: 13 givenname: Theresa T surname: Pizarro fullname: Pizarro, Theresa T |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/16505137$$D View this record in MEDLINE/PubMed |
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Cites_doi | 10.1111/1523-1747.ep12506462 10.1016/0016-5085(93)90638-S 10.1152/ajpgi.00173.2003 10.1053/gast.2003.50092 10.1128/IAI.68.12.7010-7017.2000 10.1016/S0002-9440(10)63051-9 10.4049/jimmunol.169.9.5308 10.1002/eji.200324680 10.1067/msy.2003.143 10.7326/0003-4819-105-6-883 10.1053/j.gastro.2004.11.001 10.1093/intimm/5.11.1461 10.1146/annurev.immunol.20.100301.064816 10.4049/jimmunol.162.11.6829 10.1097/00054725-199911000-00004 10.1053/j.gastro.2004.01.062 10.1038/labinvest.3700050 10.1083/jcb.153.2.263 10.1016/S0016-5085(98)70636-5 10.1111/j.1749-6632.2000.tb05261.x 10.4049/jimmunol.157.3.1261 10.1016/S0140-6736(02)11437-1 10.1038/ni1101-1004 10.1038/nri1132 10.1053/gast.2001.29568 10.1074/jbc.M008072200 10.1242/jcs.01235 10.1053/gast.2003.50148 10.1053/gast.2002.36578 10.1152/ajpcell.00558.2003 10.1046/j.1365-2249.2002.01804.x 10.4049/jimmunol.171.11.6164 10.1053/gast.2002.36002 10.1073/pnas.1432897100 10.1016/S0016-5085(97)70128-8 10.1084/jem.148.6.1687 10.1016/S0016-5085(98)70525-6 10.1007/BF01969102 10.1053/gast.2003.50153 10.4049/jimmunol.170.8.3939 10.1046/j.1462-5822.2000.00055.x 10.3181/00379727-214-44099 10.1053/j.gastro.2004.03.076 10.1016/S0016-5085(03)00876-X 10.1172/JCI10956 10.1172/JCI200420855 10.1016/S0140-6736(02)07284-7 10.1016/0140-6736(93)90882-H 10.1053/bega.2002.0339 10.1136/gut.43.1.71 10.1034/j.1600-065X.2001.1820115.x |
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Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Abbreviations used: BMT, bone marrow transplant; CD, Crohn's disease; CLDN, claudin; FE, fractional excretion; GF, germ-free; HGPRT, hypoxanthine-guanine phosphoribosyl transferase; MLN, mesenteric lymph node; MPO, myeloperoxidase; SAMP, SAMP1/YitFc; SPF, specific pathogen-free; TEER, transepithelial electrical resistance; TJ, tight junction. T.S. Olson and B.K. Reuter contributed equally to this work. CORRESPONDENCE Theresa T. Pizarro: ttp4e@virginia.edu |
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References | 9098000 - Gastroenterology. 1997 Apr;112(4):1169-78 12682220 - J Immunol. 2003 Apr 15;170(8):3939-43 11207587 - Cell Microbiol. 2000 Aug;2(4):305-15 12360480 - Gastroenterology. 2002 Oct;123(4):1179-90 9496932 - Gastroenterology. 1998 Mar;114(3):433-40 12796725 - Surgery. 2003 Jun;133(6):601-7 12391251 - J Immunol. 2002 Nov 1;169(9):5308-14 12671896 - Gastroenterology. 2003 Apr;124(4):993-1000 11309408 - J Cell Biol. 2001 Apr 16;153(2):263-72 11685223 - Nat Immunol. 2001 Nov;2(11):1004-9 12891551 - Gastroenterology. 2003 Aug;125(2):477-90 15286805 - J Clin Invest. 2004 Aug;114(3):389-98 14767487 - Lab Invest. 2004 Mar;84(3):282-91 363972 - J Exp Med. 1978 Dec 1;148(6):1687-98 9428222 - Gastroenterology. 1998 Jan;114(1):83-92 12473295 - Best Pract Res Clin Gastroenterol. 2002 Dec;16(6):851-67 12433518 - Lancet. 2002 Nov 9;360(9344):1478-80 11193596 - Ann N Y Acad Sci. 2000;915:333-8 10579119 - Inflamm Bowel Dis. 1999 Nov;5(4):262-70 11722634 - Immunol Rev. 2001 Aug;182:190-200 8099141 - Lancet. 1993 Jun 5;341(8858):1437-9 11809204 - Lancet. 2002 Jan 5;359(9300):62-9 11083826 - Infect Immun. 2000 Dec;68(12):7010-7 12832622 - Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8366-71 6276474 - J Invest Dermatol. 1982 Mar;78(3):206-9 11254669 - J Clin Invest. 2001 Mar;107(6):695-702 11982597 - Clin Exp Immunol. 2002 Apr;128(1):102-9 15159449 - J Cell Sci. 2004 May 15;117(Pt 12):2435-47 11861611 - Annu Rev Immunol. 2002;20:495-549 3777713 - Ann Intern Med. 1986 Dec;105(6):883-5 12671894 - Gastroenterology. 2003 Apr;124(4):972-82 7903159 - Int Immunol. 1993 Nov;5(11):1461-71 11733350 - Am J Pathol. 2001 Dec;159(6):2001-9 12612906 - Gastroenterology. 2003 Mar;124(3):672-82 15151915 - Am J Physiol Cell Physiol. 2004 Jun;286(6):C1213-28 8500719 - Gastroenterology. 1993 Jun;104(6):1627-32 14634132 - J Immunol. 2003 Dec 1;171(11):6164-72 9771408 - Gut. 1998 Jul;43(1):71-8 10828911 - Mt Sinai J Med. 2000 May;67(3):263-8 12404235 - Gastroenterology. 2002 Nov;123(5):1607-15 14766535 - Am J Physiol Gastrointest Liver Physiol. 2004 Mar;286(3):G367-76 15188172 - Gastroenterology. 2004 Jun;126(7):1771-8 11087742 - J Biol Chem. 2001 Feb 16;276(7):4812-8 2847506 - Agents Actions. 1988 Aug;25(1-2):115-23 9111522 - Proc Soc Exp Biol Med. 1997 Apr;214(4):318-27 15168368 - Gastroenterology. 2004 May;126(6):1574-81 7429506 - Hum Pathol. 1980 Sep;11(5 Suppl):561-71 8757634 - J Immunol. 1996 Aug 1;157(3):1261-70 8536356 - Clin Exp Immunol. 1995 Dec;102(3):448-55 11729122 - Gastroenterology. 2001 Dec;121(6):1428-36 12876555 - Nat Rev Immunol. 2003 Jul;3(7):521-33 15685547 - Gastroenterology. 2005 Feb;128(2):351-60 10352304 - J Immunol. 1999 Jun 1;162(11):6829-35 15162425 - Eur J Immunol. 2004 Jun;34(6):1561-9 (2023072513341120500_BIB50) 1980; 11 (2023072513341120500_BIB19) 1999; 162 (2023072513341120500_BIB34) 1998; 43 (2023072513341120500_BIB36) 2001; 107 (2023072513341120500_BIB30) 2000; 2 (2023072513341120500_BIB5) 2001; 276 (2023072513341120500_BIB48) 2003; 171 (2023072513341120500_BIB6) 2003; 124 (2023072513341120500_BIB13) 1995; 102 (2023072513341120500_BIB28) 2001; 153 (2023072513341120500_BIB40) 2002; 169 (2023072513341120500_BIB21) 2000; 915 (2023072513341120500_BIB11) 2001; 182 (2023072513341120500_BIB20) 2003; 133 (2023072513341120500_BIB47) 2001; 2 (2023072513341120500_BIB25) 2004; 286 (2023072513341120500_BIB16) 2002; 360 (2023072513341120500_BIB18) 2000; 68 (2023072513341120500_BIB8) 1996; 157 (2023072513341120500_BIB33) 1932; 99 (2023072513341120500_BIB9) 2003; 170 (2023072513341120500_BIB41) 2003; 125 (2023072513341120500_BIB43) 2001; 121 (2023072513341120500_BIB22) 1986; 105 (2023072513341120500_BIB53) 1982; 78 (2023072513341120500_BIB45) 1998; 114 (2023072513341120500_BIB38) 2004; 114 (2023072513341120500_BIB37) 2004; 34 (2023072513341120500_BIB51) 2002; 123 (2023072513341120500_BIB54) 1988; 25 (2023072513341120500_BIB12) 2004; 126 (2023072513341120500_BIB4) 2002; 359 (2023072513341120500_BIB10) 1993; 5 (2023072513341120500_BIB44) 2002; 123 (2023072513341120500_BIB17) 1998; 114 (2023072513341120500_BIB24) 1993; 341 (2023072513341120500_BIB49) 1999; 5 (2023072513341120500_BIB14) 2002; 128 (2023072513341120500_BIB27) 2004; 84 (2023072513341120500_BIB52) 2001; 159 (2023072513341120500_BIB32) 2002; 20 (2023072513341120500_BIB31) 2004; 286 (2023072513341120500_BIB26) 2002; 16 (2023072513341120500_BIB23) 1993; 104 (2023072513341120500_BIB46) 1978; 148 (2023072513341120500_BIB7) 1997; 112 (2023072513341120500_BIB15) 2003; 124 (2023072513341120500_BIB29) 2004; 117 (2023072513341120500_BIB3) 1997; 214 (2023072513341120500_BIB42) 2005; 128 (2023072513341120500_BIB35) 2003; 124 (2023072513341120500_BIB1) 2003; 3 (2023072513341120500_BIB2) 2004; 126 (2023072513341120500_BIB39) 2003; 100 |
References_xml | – volume: 99 start-page: 1323 year: 1932 ident: 2023072513341120500_BIB33 publication-title: Mt. Sinai J. Med. – volume: 78 start-page: 206 year: 1982 ident: 2023072513341120500_BIB53 publication-title: J. Invest. Dermatol. doi: 10.1111/1523-1747.ep12506462 – volume: 11 start-page: 561 year: 1980 ident: 2023072513341120500_BIB50 publication-title: Hum. Pathol. – volume: 102 start-page: 448 year: 1995 ident: 2023072513341120500_BIB13 publication-title: Clin. Exp. Immunol. – volume: 104 start-page: 1627 year: 1993 ident: 2023072513341120500_BIB23 publication-title: Gastroenterology. doi: 10.1016/0016-5085(93)90638-S – volume: 286 start-page: G367 year: 2004 ident: 2023072513341120500_BIB31 publication-title: Am. J. Physiol. Gastrointest. Liver Physiol. doi: 10.1152/ajpgi.00173.2003 – volume: 124 start-page: 672 year: 2003 ident: 2023072513341120500_BIB15 publication-title: Gastroenterology. doi: 10.1053/gast.2003.50092 – volume: 68 start-page: 7010 year: 2000 ident: 2023072513341120500_BIB18 publication-title: Infect. Immun. doi: 10.1128/IAI.68.12.7010-7017.2000 – volume: 159 start-page: 2001 year: 2001 ident: 2023072513341120500_BIB52 publication-title: Am. J. Pathol. doi: 10.1016/S0002-9440(10)63051-9 – volume: 169 start-page: 5308 year: 2002 ident: 2023072513341120500_BIB40 publication-title: J. Immunol. doi: 10.4049/jimmunol.169.9.5308 – volume: 34 start-page: 1561 year: 2004 ident: 2023072513341120500_BIB37 publication-title: Eur. J. Immunol. doi: 10.1002/eji.200324680 – volume: 133 start-page: 601 year: 2003 ident: 2023072513341120500_BIB20 publication-title: Surgery. doi: 10.1067/msy.2003.143 – volume: 105 start-page: 883 year: 1986 ident: 2023072513341120500_BIB22 publication-title: Ann. Intern. Med. doi: 10.7326/0003-4819-105-6-883 – volume: 128 start-page: 351 year: 2005 ident: 2023072513341120500_BIB42 publication-title: Gastroenterology. doi: 10.1053/j.gastro.2004.11.001 – volume: 5 start-page: 1461 year: 1993 ident: 2023072513341120500_BIB10 publication-title: Int. Immunol. doi: 10.1093/intimm/5.11.1461 – volume: 20 start-page: 495 year: 2002 ident: 2023072513341120500_BIB32 publication-title: Annu. Rev. Immunol. doi: 10.1146/annurev.immunol.20.100301.064816 – volume: 162 start-page: 6829 year: 1999 ident: 2023072513341120500_BIB19 publication-title: J. Immunol. doi: 10.4049/jimmunol.162.11.6829 – volume: 5 start-page: 262 year: 1999 ident: 2023072513341120500_BIB49 publication-title: Inflamm. Bowel Dis. doi: 10.1097/00054725-199911000-00004 – volume: 126 start-page: 1574 year: 2004 ident: 2023072513341120500_BIB2 publication-title: Gastroenterology. doi: 10.1053/j.gastro.2004.01.062 – volume: 84 start-page: 282 year: 2004 ident: 2023072513341120500_BIB27 publication-title: Lab. Invest. doi: 10.1038/labinvest.3700050 – volume: 153 start-page: 263 year: 2001 ident: 2023072513341120500_BIB28 publication-title: J. Cell Biol. doi: 10.1083/jcb.153.2.263 – volume: 114 start-page: 83 year: 1998 ident: 2023072513341120500_BIB45 publication-title: Gastroenterology. doi: 10.1016/S0016-5085(98)70636-5 – volume: 915 start-page: 333 year: 2000 ident: 2023072513341120500_BIB21 publication-title: Ann. NY Acad. Sci. doi: 10.1111/j.1749-6632.2000.tb05261.x – volume: 157 start-page: 1261 year: 1996 ident: 2023072513341120500_BIB8 publication-title: J. Immunol. doi: 10.4049/jimmunol.157.3.1261 – volume: 360 start-page: 1478 year: 2002 ident: 2023072513341120500_BIB16 publication-title: Lancet. doi: 10.1016/S0140-6736(02)11437-1 – volume: 2 start-page: 1004 year: 2001 ident: 2023072513341120500_BIB47 publication-title: Nat. Immunol. doi: 10.1038/ni1101-1004 – volume: 3 start-page: 521 year: 2003 ident: 2023072513341120500_BIB1 publication-title: Nat. Rev. Immunol. doi: 10.1038/nri1132 – volume: 121 start-page: 1428 year: 2001 ident: 2023072513341120500_BIB43 publication-title: Gastroenterology. doi: 10.1053/gast.2001.29568 – volume: 276 start-page: 4812 year: 2001 ident: 2023072513341120500_BIB5 publication-title: J. Biol. Chem. doi: 10.1074/jbc.M008072200 – volume: 117 start-page: 2435 year: 2004 ident: 2023072513341120500_BIB29 publication-title: J. Cell Sci. doi: 10.1242/jcs.01235 – volume: 124 start-page: 972 year: 2003 ident: 2023072513341120500_BIB35 publication-title: Gastroenterology. doi: 10.1053/gast.2003.50148 – volume: 123 start-page: 1607 year: 2002 ident: 2023072513341120500_BIB44 publication-title: Gastroenterology. doi: 10.1053/gast.2002.36578 – volume: 286 start-page: C1213 year: 2004 ident: 2023072513341120500_BIB25 publication-title: Am. J. Physiol. Cell Physiol. doi: 10.1152/ajpcell.00558.2003 – volume: 128 start-page: 102 year: 2002 ident: 2023072513341120500_BIB14 publication-title: Clin. Exp. Immunol. doi: 10.1046/j.1365-2249.2002.01804.x – volume: 171 start-page: 6164 year: 2003 ident: 2023072513341120500_BIB48 publication-title: J. Immunol. doi: 10.4049/jimmunol.171.11.6164 – volume: 123 start-page: 1179 year: 2002 ident: 2023072513341120500_BIB51 publication-title: Gastroenterology. doi: 10.1053/gast.2002.36002 – volume: 100 start-page: 8366 year: 2003 ident: 2023072513341120500_BIB39 publication-title: Proc. Natl. Acad. Sci. USA. doi: 10.1073/pnas.1432897100 – volume: 112 start-page: 1169 year: 1997 ident: 2023072513341120500_BIB7 publication-title: Gastroenterology. doi: 10.1016/S0016-5085(97)70128-8 – volume: 148 start-page: 1687 year: 1978 ident: 2023072513341120500_BIB46 publication-title: J. Exp. Med. doi: 10.1084/jem.148.6.1687 – volume: 114 start-page: 433 year: 1998 ident: 2023072513341120500_BIB17 publication-title: Gastroenterology. doi: 10.1016/S0016-5085(98)70525-6 – volume: 25 start-page: 115 year: 1988 ident: 2023072513341120500_BIB54 publication-title: Agents Actions. doi: 10.1007/BF01969102 – volume: 124 start-page: 993 year: 2003 ident: 2023072513341120500_BIB6 publication-title: Gastroenterology. doi: 10.1053/gast.2003.50153 – volume: 170 start-page: 3939 year: 2003 ident: 2023072513341120500_BIB9 publication-title: J. Immunol. doi: 10.4049/jimmunol.170.8.3939 – volume: 2 start-page: 305 year: 2000 ident: 2023072513341120500_BIB30 publication-title: Cell. Microbiol. doi: 10.1046/j.1462-5822.2000.00055.x – volume: 214 start-page: 318 year: 1997 ident: 2023072513341120500_BIB3 publication-title: Proc. Soc. Exp. Biol. Med. doi: 10.3181/00379727-214-44099 – volume: 126 start-page: 1771 year: 2004 ident: 2023072513341120500_BIB12 publication-title: Gastroenterology. doi: 10.1053/j.gastro.2004.03.076 – volume: 125 start-page: 477 year: 2003 ident: 2023072513341120500_BIB41 publication-title: Gastroenterology. doi: 10.1016/S0016-5085(03)00876-X – volume: 107 start-page: 695 year: 2001 ident: 2023072513341120500_BIB36 publication-title: J. Clin. Invest. doi: 10.1172/JCI10956 – volume: 114 start-page: 389 year: 2004 ident: 2023072513341120500_BIB38 publication-title: J. Clin. Invest. doi: 10.1172/JCI200420855 – volume: 359 start-page: 62 year: 2002 ident: 2023072513341120500_BIB4 publication-title: Lancet. doi: 10.1016/S0140-6736(02)07284-7 – volume: 341 start-page: 1437 year: 1993 ident: 2023072513341120500_BIB24 publication-title: Lancet. doi: 10.1016/0140-6736(93)90882-H – volume: 16 start-page: 851 year: 2002 ident: 2023072513341120500_BIB26 publication-title: Best Pract. Res. Clin. Gastroenterol. doi: 10.1053/bega.2002.0339 – volume: 43 start-page: 71 year: 1998 ident: 2023072513341120500_BIB34 publication-title: Gut. doi: 10.1136/gut.43.1.71 – volume: 182 start-page: 190 year: 2001 ident: 2023072513341120500_BIB11 publication-title: Immunol. Rev. doi: 10.1034/j.1600-065X.2001.1820115.x |
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Snippet | The initiating etiologic factor in Crohn's disease (CD) remains unclear. SAMP1/YitFc (SAMP) mice develop chronic ileitis similar to human CD. We used bone... |
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SubjectTerms | Animals Bacteria - immunology Bone Marrow Transplantation Cell Membrane Permeability - genetics Cell Membrane Permeability - immunology Claudins Crohn Disease - genetics Crohn Disease - immunology Crohn Disease - pathology Cytokines - immunology Disease Models, Animal Epithelium - immunology Epithelium - pathology Gene Expression Regulation - genetics Gene Expression Regulation - immunology Hematopoiesis - immunology Humans Ileitis - genetics Ileitis - immunology Ileitis - pathology Inflammation - genetics Inflammation - immunology Inflammation - pathology Lymphocytes - immunology Lymphocytes - pathology Membrane Proteins - genetics Membrane Proteins - immunology Mice Mice, Transgenic Occludin |
Title | The primary defect in experimental ileitis originates from a nonhematopoietic source |
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