Polyelectrolyte Microcapsules—A Promising Target Delivery System of Amiodarone with the Possibility of Prolonged Release

• Published in: International journal of molecular sciences Vol. 24; no. 4; p. 3348
• Main Authors: Kim, Aleksandr L., Musin, Egor V., Oripova, Munojat J., Oshchepkova, Yulia I., Salikhov, Shavkat I., Tikhonenko, Sergey A.
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 08.02.2023; MDPI
• Subjects: Adsorption; Amiodarone; Atrial fibrillation; Capsules - chemistry; Cardiac arrhythmia; Drug Delivery Systems; Electrical conductivity; Ethylenediaminetetraacetic acid; Heart; Nanoparticles; Polyelectrolytes; Product introduction; encapsulation; drug delivery; amiodarone; polyelectrolyte microcapsules; target delivery

Atrial fibrillation is one of the most common cardiac arrhythmias. Pharmacological preparations are used for treatment to control heart rate and rhythm. Amiodarone is one of these highly effective preparations, but, at the same time, it has significant toxicity and nonspecific accumulation in tissue...