TRPV1 and TRPM8 Channels and Nocifensive Behavior in a Rat Model for Dry Eye

• Published in: Investigative ophthalmology & visual science Vol. 59; no. 8; pp. 3739 - 3746
• Main Authors: Bereiter, David A., Rahman, Mostafeezur, Thompson, Randall, Stephenson, Pannaporn, Saito, Hiroto
• Format: Journal Article
• Language: English
• Published: United States The Association for Research in Vision and Ophthalmology 01.07.2018
• Subjects: Animals; Disease Models, Animal; Dry Eye Syndromes - genetics; Dry Eye Syndromes - metabolism; Dry Eye Syndromes - pathology; Gene Expression Regulation; Male; Physiology and Pharmacology; Polymerase Chain Reaction; Rats; Rats, Sprague-Dawley; RNA - genetics; Tears - metabolism; TRPM Cation Channels - biosynthesis; TRPM Cation Channels - genetics; TRPV Cation Channels - biosynthesis; TRPV Cation Channels - genetics
• ISSN: 1552-5783; 0146-0404; 1552-5783
• DOI: 10.1167/iovs.18-24304

Persistent ocular surface pain occurs in moderate to severe dry eye disease (DE); however, the mechanisms that underlie this symptom remain uncertain. The aim of this study was to determine if the transient receptor potential vanilloid ion channels play a role in hypertonic saline (HS)-evoked cornea...