Intravenous immunoglobulin therapy in intractable childhood epilepsy: Open-label study and review of the literature

• Published in: Epilepsy & behavior Vol. 17; no. 1; pp. 90 - 94
• Main Authors: Mikati, Mohamad A, Kurdi, Rana, El-Khoury, Ziad, Rahi, Amal, Raad, Wissam
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.01.2010
• Subjects: Adolescent; Child; Child, Preschool; Epilepsy; Epilepsy - classification; Epilepsy - drug therapy; Epilepsy - physiopathology; Female; Generalized seizures; Humans; Immunoglobulins, Intravenous - administration & dosage; Immunologic Factors - administration & dosage; Infantile spasms; Intravenous gamma globulin; Lennox–Gastaut syndrome; Longitudinal Studies; Male; Multivariate Analysis; Neurology; Partial seizures; Therapy; West syndrome; Young Adult; Therapy; West syndrome; Infantile spasms; Epilepsy; Generalized seizures; Lennox–Gastaut syndrome; Child; Partial seizures; Intravenous gamma globulin

Abstract Our aim was to investigate the long term effectiveness of intravenous immunoglobulin (IVIG) against intractable childhood epilepsy in the era of new antiepileptics and to determine the predictors of a favorable response in a prospective open-label add-on study. Of thirty-seven 9.9 ± 0.9-yea...