mir-605-3p prevents liver premetastatic niche formation by inhibiting angiogenesis via decreasing exosomal nos3 release in gastric cancer

• Published in: Cancer cell international Vol. 24; no. 1; p. 184
• Main Authors: Hu, Yilin, Zang, Weijie, Feng, Ying, Mao, Qinsheng, Chen, Junjie, Zhu, Yizhun, Xue, Wanjiang
• Format: Journal Article
• Language: English
• Published: England BioMed Central 27.05.2024; BMC
• Subjects: Angiogenesis; Bioinformatics; Cell membranes; Cells; Endothelial cells; Enzyme-linked immunosorbent assay; Exosomes; Gastric cancer; Genes; Guanylate cyclase; Immunofluorescence; Liver; Membrane proteins; Metastases; Metastasis; MicroRNAs; miR-605-3p; miRNA; Molecular modelling; Nanoparticles; Nitric-oxide synthase; NOS3 protein; Plasma; Plasmids; Premetastatic niche; Proteins; Surgery; Transmission electron microscopy; Umbilical vein; United States > US; China; Angiogenesis; miR-605-3p; Exosomes; Premetastatic niche; Gastric cancer

Cancer-induced pre-metastatic niches (PMNs) play a decisive role in promoting metastasis by facilitating angiogenesis in distant sites. Evidence accumulates suggesting that microRNAs (miRNAs) exert significant influence on angiogenesis during PMN formation, yet their specific roles and regulatory me...