Adenosine in fibrosis

Adenosine is an endogenous autocoid that regulates a multitude of bodily functions. Its anti-inflammatory actions are well known to rheumatologists since it mediates many of the anti-inflammatory effects of a number of antirheumatic drugs such as methotrexate. However, inflammatory and tissue regene...

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Bibliographic Details
Published inModern rheumatology Vol. 20; no. 2; pp. 114 - 122
Main Authors Chan, Edwin S. L., Cronstein, Bruce N.
Format Journal Article
LanguageEnglish
Published Japan Springer Japan 01.04.2010
Informa Healthcare
Subjects
Adenosine
Adenosine - physiology
Animals
Biochemistry
Fibrosis - physiopathology
Humans
Medicine
Medicine & Public Health
Mice
Orthopedics
Purinergic P1 Receptor Agonists
Receptors, Purinergic P1 - physiology
Review Article
Rheumatology
Scleroderma
Signal Transduction
Tissues
Wound Healing - physiology
Cirrhosis
Adenosine receptor
Collagen
Fibrosis
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Summary:Adenosine is an endogenous autocoid that regulates a multitude of bodily functions. Its anti-inflammatory actions are well known to rheumatologists since it mediates many of the anti-inflammatory effects of a number of antirheumatic drugs such as methotrexate. However, inflammatory and tissue regenerative responses are intricately linked, with wound healing being a prime example. It has only recently been appreciated that adenosine has a key role in tissue regenerative and fibrotic processes. An understanding of these processes may shed new light on potential therapeutic options in diseases such as scleroderma where tissue fibrosis features prominently.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:1439-7595
1439-7609
DOI:10.1007/s10165-009-0251-4