Novel pendrin inhibitor attenuates airway hyperresponsiveness and mucin expression in experimental murine asthma

• Published in: Journal of allergy and clinical immunology Vol. 144; no. 5; pp. 1425 - 1428.e12
• Main Authors: Park, Jinhong, Lee, Hyun Jae, Song, Doona, Gi, Mia, Jo, Sungwoo, Jeon, Dong-kyu, Seo, Yohan, Kim, Bomin, Lee, Ho, Namkung, Wan, Han, Gyoonhee, Choi, Jae Young
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.11.2019; Elsevier Limited
• Subjects: Actin; Asthma; Cystic fibrosis; Gene expression; Inflammation; Lungs; Lysine; Mucin; Poly-L-lysine; Polymerase chain reaction; Protein expression; Respiratory tract; Respiratory tract diseases; Sodium channels; Sodium conductance; Statistical analysis; Thallium; Trinucleotide repeats

To the Editor: The transmembrane anion exchanger pendrin (SCL26A4) exchanges Cl− with bases, such as HCO3−, I−, and SCN−, and is the most highly upregulated gene in endobronchial biopsies from patients with asthma.1,2 Interestingly, patients with mutant pendrin have a low prevalence of asthma, and p...