Mechanisms of mitochondrial dysfunction and their impact on age-related macular degeneration

• Published in: Progress in retinal and eye research Vol. 79; p. 100858
• Main Authors: Kaarniranta, Kai, Uusitalo, Hannu, Blasiak, Janusz, Felszeghy, Szabolcs, Kannan, Ram, Kauppinen, Anu, Salminen, Antero, Sinha, Debasish, Ferrington, Deborah
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.11.2020
• Subjects: Age-related macular degeneration; Aggregation; Aging; Autophagy; Clearance; Degeneration; Humans; Lysosomes - metabolism; Macular Degeneration - genetics; Macular Degeneration - metabolism; Mitochondria; Mitochondria - metabolism; Mitophagy; Oxidative Stress; Retina; Retinal pigment epithelium; Retinal Pigment Epithelium - metabolism; Signal Transduction; Aggregation; Mitochondria; Age-related macular degeneration; Aging; Retina; Degeneration; Clearance; Mitophagy; Autophagy; Retinal pigment epithelium

Oxidative stress-induced damage to the retinal pigment epithelium (RPE) is considered to be a key factor in age-related macular degeneration (AMD) pathology. RPE cells are constantly exposed to oxidative stress that may lead to the accumulation of damaged cellular proteins, lipids, nucleic acids, an...