Low-density lipoprotein receptor–related protein 1 attenuates house dust mite–induced eosinophilic airway inflammation by suppressing dendritic cell–mediated adaptive immune responses

Low-density lipoprotein receptor–related protein 1 (LRP-1) is a scavenger receptor that regulates adaptive immunity and inflammation. LRP-1 is not known to modulate the pathogenesis of allergic asthma. We sought to assess whether LRP-1 expression by dendritic cells (DCs) modulates adaptive immune re...

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Published inJournal of allergy and clinical immunology Vol. 142; no. 4; pp. 1066 - 1079.e6
Main Authors Mishra, Amarjit, Yao, Xianglan, Saxena, Ankit, Gordon, Elizabeth M., Kaler, Maryann, Cuento, Rosemarie A., Barochia, Amisha V., Dagur, Pradeep K., McCoy, J. Philip, Keeran, Karen J., Jeffries, Kenneth R., Qu, Xuan, Yu, Zu-Xi, Levine, Stewart J.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.10.2018
Elsevier Limited
Subjects
Adaptive Immunity
Adoptive transfer
Adult
Allergens - immunology
Allergies
Animals
Antigen presentation
Antigens, Dermatophagoides - immunology
Apolipoproteins
Asthma
Asthma - blood
Asthma - immunology
Asthma - physiopathology
Bone marrow
Bronchoalveolar Lavage Fluid - cytology
CD11b antigen
CD11c antigen
Clonal deletion
Cloning
Dendritic cells
Dendritic Cells - immunology
Dermatophagoides pteronyssinus - immunology
Dust
Eosinophilia - blood
Eosinophilia - immunology
Eosinophilia - physiopathology
eosinophilic airway inflammation
Female
Flow cytometry
Genotype & phenotype
Growth factors
house dust mite
Human subjects
Humans
Immune response
Immunoglobulin E - blood
Immunoglobulin G - blood
Inflammation
Leukocytes (eosinophilic)
Lipoproteins
Low Density Lipoprotein Receptor-Related Protein-1 - immunology
Low-density lipoprotein receptor–related protein 1
Lymphocytes
Lymphocytes T
Male
Metaplasia
Mice, Transgenic
Middle Aged
Pathogenesis
Peripheral blood
Phenotypes
Proteins
Receptor density
Respiratory tract
Respiratory tract diseases
Rodents
Scavenger receptors
type 2–high asthma
TCR
PAS
type 2–high asthma
CLR
AHR
MDC
MLN
HDM
NF-κB
moDC
dendritic cells
BMDC
LDL
DC-SIGN
VLDL
TLR
WT
SSC
house dust mite
HSP
AF
BALF
Treg
CFSE
BAL
eosinophilic airway inflammation
pDC
APC
NHLBI
Low-density lipoprotein receptor–related protein 1
PE
MHCII
LRP-1
OVA
Foxp3
PerCP
cDCs
DC
Online AccessGet full text
ISSN0091-6749
1097-6825
1097-6825
DOI10.1016/j.jaci.2017.10.044

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Abstract Low-density lipoprotein receptor–related protein 1 (LRP-1) is a scavenger receptor that regulates adaptive immunity and inflammation. LRP-1 is not known to modulate the pathogenesis of allergic asthma. We sought to assess whether LRP-1 expression by dendritic cells (DCs) modulates adaptive immune responses in patients with house dust mite (HDM)–induced airways disease. LRP-1 expression on peripheral blood DCs was quantified by using flow cytometry. The role of LRP-1 in modulating HDM-induced airways disease was assessed in mice with deletion of LRP-1 in CD11c+ cells (Lrp1fl/fl; CD11c-Cre) and by adoptive transfer of HDM-pulsed CD11b+ DCs from Lrp1fl/fl; CD11c-Cre mice to wild-type (WT) mice. Human peripheral blood myeloid DC subsets from patients with eosinophilic asthma have lower LRP-1 expression than cells from healthy nonasthmatic subjects. Similarly, LRP-1 expression by CD11b+ lung DCs was significantly reduced in HDM-challenged WT mice. HDM-challenged Lrp1fl/fl; CD11c-Cre mice have a phenotype of increased eosinophilic airway inflammation, allergic sensitization, TH2 cytokine production, and mucous cell metaplasia. The adoptive transfer of HDM-pulsed LRP-1–deficient CD11b+ DCs into WT mice generated a similar phenotype of enhanced eosinophilic inflammation and allergic sensitization. Furthermore, CD11b+ DCs in the lungs of Lrp1fl/fl; CD11c-Cre mice have an increased ability to take up HDM antigen, whereas bone marrow–derived DCs display enhanced antigen presentation capabilities. This identifies a novel role for LRP-1 as a negative regulator of DC-mediated adaptive immune responses in the setting of HDM-induced eosinophilic airway inflammation. Furthermore, the reduced LRP-1 expression by circulating myeloid DCs in patients with eosinophilic asthma suggests a possible role for LRP-1 in modulating type 2–high asthma. [Display omitted]
AbstractList Low-density lipoprotein receptor–related protein 1 (LRP-1) is a scavenger receptor that regulates adaptive immunity and inflammation. LRP-1 is not known to modulate the pathogenesis of allergic asthma. We sought to assess whether LRP-1 expression by dendritic cells (DCs) modulates adaptive immune responses in patients with house dust mite (HDM)–induced airways disease. LRP-1 expression on peripheral blood DCs was quantified by using flow cytometry. The role of LRP-1 in modulating HDM-induced airways disease was assessed in mice with deletion of LRP-1 in CD11c+ cells (Lrp1fl/fl; CD11c-Cre) and by adoptive transfer of HDM-pulsed CD11b+ DCs from Lrp1fl/fl; CD11c-Cre mice to wild-type (WT) mice. Human peripheral blood myeloid DC subsets from patients with eosinophilic asthma have lower LRP-1 expression than cells from healthy nonasthmatic subjects. Similarly, LRP-1 expression by CD11b+ lung DCs was significantly reduced in HDM-challenged WT mice. HDM-challenged Lrp1fl/fl; CD11c-Cre mice have a phenotype of increased eosinophilic airway inflammation, allergic sensitization, TH2 cytokine production, and mucous cell metaplasia. The adoptive transfer of HDM-pulsed LRP-1–deficient CD11b+ DCs into WT mice generated a similar phenotype of enhanced eosinophilic inflammation and allergic sensitization. Furthermore, CD11b+ DCs in the lungs of Lrp1fl/fl; CD11c-Cre mice have an increased ability to take up HDM antigen, whereas bone marrow–derived DCs display enhanced antigen presentation capabilities. This identifies a novel role for LRP-1 as a negative regulator of DC-mediated adaptive immune responses in the setting of HDM-induced eosinophilic airway inflammation. Furthermore, the reduced LRP-1 expression by circulating myeloid DCs in patients with eosinophilic asthma suggests a possible role for LRP-1 in modulating type 2–high asthma. [Display omitted]
BackgroundLow-density lipoprotein receptor–related protein 1 (LRP-1) is a scavenger receptor that regulates adaptive immunity and inflammation. LRP-1 is not known to modulate the pathogenesis of allergic asthma.ObjectiveWe sought to assess whether LRP-1 expression by dendritic cells (DCs) modulates adaptive immune responses in patients with house dust mite (HDM)–induced airways disease.MethodsLRP-1 expression on peripheral blood DCs was quantified by using flow cytometry. The role of LRP-1 in modulating HDM-induced airways disease was assessed in mice with deletion of LRP-1 in CD11c+ cells (Lrp1fl/fl; CD11c-Cre) and by adoptive transfer of HDM-pulsed CD11b+ DCs from Lrp1fl/fl; CD11c-Cre mice to wild-type (WT) mice.ResultsHuman peripheral blood myeloid DC subsets from patients with eosinophilic asthma have lower LRP-1 expression than cells from healthy nonasthmatic subjects. Similarly, LRP-1 expression by CD11b+ lung DCs was significantly reduced in HDM-challenged WT mice. HDM-challenged Lrp1fl/fl; CD11c-Cre mice have a phenotype of increased eosinophilic airway inflammation, allergic sensitization, TH2 cytokine production, and mucous cell metaplasia. The adoptive transfer of HDM-pulsed LRP-1–deficient CD11b+ DCs into WT mice generated a similar phenotype of enhanced eosinophilic inflammation and allergic sensitization. Furthermore, CD11b+ DCs in the lungs of Lrp1fl/fl; CD11c-Cre mice have an increased ability to take up HDM antigen, whereas bone marrow–derived DCs display enhanced antigen presentation capabilities.ConclusionThis identifies a novel role for LRP-1 as a negative regulator of DC-mediated adaptive immune responses in the setting of HDM-induced eosinophilic airway inflammation. Furthermore, the reduced LRP-1 expression by circulating myeloid DCs in patients with eosinophilic asthma suggests a possible role for LRP-1 in modulating type 2–high asthma.
Low-density lipoprotein receptor-related protein 1 (LRP-1) is a scavenger receptor that regulates adaptive immunity and inflammation. LRP-1 is not known to modulate the pathogenesis of allergic asthma. We sought to assess whether LRP-1 expression by dendritic cells (DCs) modulates adaptive immune responses in patients with house dust mite (HDM)-induced airways disease. LRP-1 expression on peripheral blood DCs was quantified by using flow cytometry. The role of LRP-1 in modulating HDM-induced airways disease was assessed in mice with deletion of LRP-1 in CD11c cells (Lrp1 ; CD11c-Cre) and by adoptive transfer of HDM-pulsed CD11b DCs from Lrp1 ; CD11c-Cre mice to wild-type (WT) mice. Human peripheral blood myeloid DC subsets from patients with eosinophilic asthma have lower LRP-1 expression than cells from healthy nonasthmatic subjects. Similarly, LRP-1 expression by CD11b lung DCs was significantly reduced in HDM-challenged WT mice. HDM-challenged Lrp1 ; CD11c-Cre mice have a phenotype of increased eosinophilic airway inflammation, allergic sensitization, T 2 cytokine production, and mucous cell metaplasia. The adoptive transfer of HDM-pulsed LRP-1-deficient CD11b DCs into WT mice generated a similar phenotype of enhanced eosinophilic inflammation and allergic sensitization. Furthermore, CD11b DCs in the lungs of Lrp1 ; CD11c-Cre mice have an increased ability to take up HDM antigen, whereas bone marrow-derived DCs display enhanced antigen presentation capabilities. This identifies a novel role for LRP-1 as a negative regulator of DC-mediated adaptive immune responses in the setting of HDM-induced eosinophilic airway inflammation. Furthermore, the reduced LRP-1 expression by circulating myeloid DCs in patients with eosinophilic asthma suggests a possible role for LRP-1 in modulating type 2-high asthma.
Low-density lipoprotein receptor-related protein 1 (LRP-1) is a scavenger receptor that regulates adaptive immunity and inflammation. LRP-1 is not known to modulate the pathogenesis of allergic asthma.BACKGROUNDLow-density lipoprotein receptor-related protein 1 (LRP-1) is a scavenger receptor that regulates adaptive immunity and inflammation. LRP-1 is not known to modulate the pathogenesis of allergic asthma.We sought to assess whether LRP-1 expression by dendritic cells (DCs) modulates adaptive immune responses in patients with house dust mite (HDM)-induced airways disease.OBJECTIVEWe sought to assess whether LRP-1 expression by dendritic cells (DCs) modulates adaptive immune responses in patients with house dust mite (HDM)-induced airways disease.LRP-1 expression on peripheral blood DCs was quantified by using flow cytometry. The role of LRP-1 in modulating HDM-induced airways disease was assessed in mice with deletion of LRP-1 in CD11c+ cells (Lrp1fl/fl; CD11c-Cre) and by adoptive transfer of HDM-pulsed CD11b+ DCs from Lrp1fl/fl; CD11c-Cre mice to wild-type (WT) mice.METHODSLRP-1 expression on peripheral blood DCs was quantified by using flow cytometry. The role of LRP-1 in modulating HDM-induced airways disease was assessed in mice with deletion of LRP-1 in CD11c+ cells (Lrp1fl/fl; CD11c-Cre) and by adoptive transfer of HDM-pulsed CD11b+ DCs from Lrp1fl/fl; CD11c-Cre mice to wild-type (WT) mice.Human peripheral blood myeloid DC subsets from patients with eosinophilic asthma have lower LRP-1 expression than cells from healthy nonasthmatic subjects. Similarly, LRP-1 expression by CD11b+ lung DCs was significantly reduced in HDM-challenged WT mice. HDM-challenged Lrp1fl/fl; CD11c-Cre mice have a phenotype of increased eosinophilic airway inflammation, allergic sensitization, TH2 cytokine production, and mucous cell metaplasia. The adoptive transfer of HDM-pulsed LRP-1-deficient CD11b+ DCs into WT mice generated a similar phenotype of enhanced eosinophilic inflammation and allergic sensitization. Furthermore, CD11b+ DCs in the lungs of Lrp1fl/fl; CD11c-Cre mice have an increased ability to take up HDM antigen, whereas bone marrow-derived DCs display enhanced antigen presentation capabilities.RESULTSHuman peripheral blood myeloid DC subsets from patients with eosinophilic asthma have lower LRP-1 expression than cells from healthy nonasthmatic subjects. Similarly, LRP-1 expression by CD11b+ lung DCs was significantly reduced in HDM-challenged WT mice. HDM-challenged Lrp1fl/fl; CD11c-Cre mice have a phenotype of increased eosinophilic airway inflammation, allergic sensitization, TH2 cytokine production, and mucous cell metaplasia. The adoptive transfer of HDM-pulsed LRP-1-deficient CD11b+ DCs into WT mice generated a similar phenotype of enhanced eosinophilic inflammation and allergic sensitization. Furthermore, CD11b+ DCs in the lungs of Lrp1fl/fl; CD11c-Cre mice have an increased ability to take up HDM antigen, whereas bone marrow-derived DCs display enhanced antigen presentation capabilities.This identifies a novel role for LRP-1 as a negative regulator of DC-mediated adaptive immune responses in the setting of HDM-induced eosinophilic airway inflammation. Furthermore, the reduced LRP-1 expression by circulating myeloid DCs in patients with eosinophilic asthma suggests a possible role for LRP-1 in modulating type 2-high asthma.CONCLUSIONThis identifies a novel role for LRP-1 as a negative regulator of DC-mediated adaptive immune responses in the setting of HDM-induced eosinophilic airway inflammation. Furthermore, the reduced LRP-1 expression by circulating myeloid DCs in patients with eosinophilic asthma suggests a possible role for LRP-1 in modulating type 2-high asthma.
Author Saxena, Ankit
Keeran, Karen J.
Kaler, Maryann
Yao, Xianglan
Cuento, Rosemarie A.
Jeffries, Kenneth R.
McCoy, J. Philip
Levine, Stewart J.
Barochia, Amisha V.
Mishra, Amarjit
Qu, Xuan
Yu, Zu-Xi
Dagur, Pradeep K.
Gordon, Elizabeth M.
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Cites_doi 10.1136/thoraxjnl-2014-206069
10.1016/j.ajpath.2013.08.029
10.4049/jimmunol.172.11.7095
10.4049/jimmunol.172.1.70
10.1172/JCI119234
10.4049/jimmunol.170.11.5502
10.3389/fnagi.2014.00093
10.1146/annurev.bi.63.070194.003125
10.1186/s12974-016-0772-7
10.1165/rcmb.2007-0025OC
10.1182/blood-2013-06-510875
10.1093/intimm/12.11.1539
10.1084/jem.20101563
10.1074/jbc.M200425200
10.1038/nri723
10.4049/jimmunol.173.11.7003
10.4049/jimmunol.1502393
10.1056/NEJMoa0808991
10.1056/NEJMoa1304048
10.1164/ajrccm.157.1.9703002
10.1067/mai.2001.118600
10.1016/j.matbio.2009.08.003
10.4049/jimmunol.172.6.3842
10.1084/jem.20042311
10.4049/jimmunol.172.9.5277
10.1165/ajrcmb.16.3.9070619
10.1038/77835
10.1056/NEJMoa1106469
10.1164/rccm.201002-0308OC
10.1371/journal.pone.0053242
10.1084/jem.188.11.2019
10.1158/0008-5472.CAN-08-3379
10.1165/rcmb.2011-0071OC
10.1126/science.1082095
10.1038/ncomms7224
10.1165/rcmb.2013-0001OC
10.1007/s00441-013-1699-2
10.1016/S1074-7613(01)00111-X
10.1513/AnnalsATS.201405-218AW
10.1016/S0264-410X(01)00361-9
10.1074/jbc.M406037200
10.4049/jimmunol.152.4.1538
10.1161/01.RES.0000260204.40510.aa
10.1097/MOL.0b013e32835e809c
10.1152/physrev.00033.2007
10.1016/j.jaci.2012.03.012
10.1016/S1074-7613(02)00276-5
10.1016/j.jaci.2003.09.011
10.1016/S0140-6736(12)60988-X
10.4049/jimmunol.182.1.623
10.1172/JCI72051
10.1016/j.bcp.2010.09.018
10.1186/s12890-016-0263-8
10.1073/pnas.100118997
10.4049/jimmunol.169.3.1524
10.1056/NEJM199010113231505
10.1038/nm.2920
10.1073/pnas.1515480113
10.1016/1074-7613(95)90032-2
10.1182/blood-2007-12-127613
10.1016/j.immuni.2012.10.016
10.1038/ncomms1524
10.1111/cea.12345
10.1074/jbc.M410265200
10.1164/rccm.201208-1414OC
10.1073/pnas.0810713105
10.1016/S0092-8674(03)00758-X
10.4049/jimmunol.181.9.6525
10.4049/jimmunol.1301234
10.1172/JCI5909
10.1172/JCI116283
10.1038/nri.2016.55
10.1172/JCI200113992
10.4049/jimmunol.165.11.6037
10.1038/mi.2013.74
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1097-6825
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Mon Jul 21 06:05:31 EDT 2025
Tue Jul 01 00:47:31 EDT 2025
Thu Apr 24 22:57:13 EDT 2025
Sun Apr 06 06:53:19 EDT 2025
Tue Aug 26 16:36:29 EDT 2025
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Issue 4
Keywords TCR
PAS
type 2–high asthma
CLR
AHR
MDC
MLN
HDM
NF-κB
moDC
dendritic cells
BMDC
LDL
DC-SIGN
VLDL
TLR
WT
SSC
house dust mite
HSP
AF
BALF
Treg
CFSE
BAL
eosinophilic airway inflammation
pDC
APC
NHLBI
Low-density lipoprotein receptor–related protein 1
PE
MHCII
LRP-1
OVA
Foxp3
PerCP
cDCs
DC
Language English
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References May, Bock, Nofer (bib17) 2013; 354
Freeman, Boussiotis, Anumanthan, Bernstein, Ke, Rennert (bib63) 1995; 2
Yang, Liu, Zheng, Kanekiyo, Atagi, Jia (bib18) 2016; 13
Basu, Binder, Suto, Anderson, Srivastava (bib52) 2000; 12
Zhu, Homer, Wang, Chen, Geba, Wang (bib60) 1999; 103
Pope, Fulkerson, Blanchard, Akei, Nikolaidis, Zimmermann (bib76) 2005; 280
Tobian, Canaday, Boom, Harding (bib22) 2004; 172
Geijtenbeek, Gringhuis (bib41) 2016; 16
Binder, Han, Srivastava (bib20) 2000; 1
Krieger, Herz (bib4) 1994; 63
Masten, Yates, Koga, Lipscomb (bib64) 1997; 16
Wenzel, Ford, Pearlman, Spector, Sher, Skobieranda (bib29) 2013; 368
Hammad, Lambrecht, Pochard, Gosset, Marquillies, Tonnel (bib77) 2002; 169
Herz, Strickland (bib1) 2001; 108
Casciano, Krishnan, Small, Buck, Gopalan, Li (bib54) 2016; 16
Song, Li, Lee, Schwartz, Bu (bib11) 2009; 69
Hodge, Hodge, Ahern, Jersmann, Holmes, Reynolds (bib57) 2007; 37
Hanania, Wenzel, Rosen, Hsieh, Mosesova, Choy (bib33) 2013; 187
May (bib15) 2013; 24
Takayama, May, Anderson, Herz (bib10) 2005; 280
Dzionek, Fuchs, Schmidt, Cremer, Zysk, Miltenyi (bib26) 2000; 165
Mantuano, Brifault, Lam, Azmoon, Gilder, Gonias (bib7) 2016; 113
Hadeiba, Locksley (bib62) 2003; 170
Lambrecht, Hammad (bib73) 2014; 119
Yao, Fredriksson, Yu, Xu, Raghavachari, Keeran (bib67) 2010; 182
Zhang, Simpson, Powell, Yang, Upham, Reynolds (bib34) 2014; 44
Stumbles, Thomas, Pimm, Lee, Venaille, Proksch (bib43) 1998; 188
Gonias, Campana (bib8) 2014; 184
Yao, Gao, Dai, Meyer, Chen, Keeran (bib68) 2013; 49
Kanekiyo, Bu (bib5) 2014; 6
Poynter, Cloots, van Woerkom, Butnor, Vacek, Taatjes (bib66) 2004; 173
Crimi, Spanevello, Neri, Ind, Rossi, Brusasco (bib69) 1998; 157
Plantinga, Guilliams, Vanheerswynghels, Deswarte, Branco-Madeira, Toussaint (bib36) 2013; 38
Chu, Oury, Enghild, Pizzo (bib49) 1994; 152
Mould, Matthaei, Young, Foster (bib59) 1997; 99
Pawaria, Binder (bib21) 2011; 2
Haldar, Brightling, Hargadon, Gupta, Monteiro, Sousa (bib31) 2009; 360
Pavord, Korn, Howarth, Bleecker, Buhl, Keene (bib32) 2012; 380
Fredriksson, Mishra, Lam, Mushaben, Cuento, Meyer (bib25) 2014; 192
Overton, Yancey, Major, Linton, Fazio (bib13) 2007; 100
Julia, Hessel, Malherbe, Glaichenhaus, O'Garra, Coffman (bib74) 2002; 16
Vabulas, Braedel, Hilf, Singh-Jasuja, Herter, Ahmad-Nejad (bib47) 2002; 277
Boucher, Gotthardt, Li, Anderson, Herz (bib12) 2003; 300
Figdor, van Kooyk, Adema (bib40) 2002; 2
van Rijt, Jung, KleinJan, Vos, Willart, Duez (bib42) 2005; 201
Hart, Gunn, Pizzo (bib45) 2004; 172
D'Alise, Auyeung, Feuerer, Nishio, Fontenot, Benoist (bib28) 2008; 105
Ito, Hirose, Norimoto, Tamachi, Yokota, Saku (bib38) 2017; 198
Mishra, Brown, Yao, Yang, Park, Liu (bib27) 2015; 6
Bousquet, Chanez, Lacoste, Barneon, Ghavanian, Enander (bib53) 1990; 323
Mesnil, Sabatel, Marichal, Toussaint, Cataldo, Drion (bib75) 2012; 7
Boucher, Herz (bib6) 2011; 81
Hammad, Plantinga, Deswarte, Pouliot, Willart, Kool (bib44) 2010; 207
Pope, Brandt, Mishra, Hogan, Zimmermann, Matthaei (bib58) 2001; 108
Ishii, Nagase, Shindou, Takizawa, Ouchi, Shimizu (bib70) 2004; 172
Haldar, Brightling, Hargadon, Gupta, Monteiro, Sousa (bib72) 2009; 360
Corren, Lemanske, Hanania, Korenblat, Parsey, Arron (bib30) 2011; 365
Cianciolo, Enghild, Pizzo (bib50) 2001; 20
Hancock, Romieu, Chiu, Sienra-Monge, Li, Estela Del Rio-Navarro (bib48) 2012; 129
Yao, Fredriksson, Yu, Xu, Raghavachari, Keeran (bib24) 2010; 182
Wilson, Maruoka, Whitehead, Foley, Flake, Sever (bib65) 2012; 18
Weckbach, Gola, Winkelmann, Jakob, Groesser, Borgolte (bib14) 2014; 123
LaMarre, Wolf, Kittler, Quesenberry, Gonias (bib56) 1993; 91
Gaultier, Arandjelovic, Niessen, Overton, Linton, Fazio (bib16) 2008; 111
Tucker, Williams, Koenig, Kothari, Komissarov, Florova (bib9) 2012; 46
Basu, Binder, Ramalingam, Srivastava (bib51) 2001; 14
Jaffar, Sivakuru, Roberts (bib61) 2004; 172
Arron, Izuhara (bib35) 2015; 70
Makela, Kanehiro, Borish, Dakhama, Loader, Joetham (bib71) 2000; 97
Gaultier, Hollister, Reynolds, Hsieh, Gonias (bib3) 2010; 29
Clarke, Davis, Campion, Foster, Heasman, Lewis (bib39) 2014; 7
Lillis, Van Duyn, Murphy-Ullrich, Strickland (bib2) 2008; 88
Gardai, Xiao, Dickinson, Nick, Voelker, Greene (bib23) 2003; 115
Medoff, Seung, Hong, Thomas, Sandall, Duffield (bib37) 2009; 182
Subramanian, Hayes, Thome, Thorp, Matsushima, Herz (bib19) 2014; 124
De Filippo, Binder, Camisaschi, Beretta, Arienti, Villa (bib46) 2008; 181
Foster, Metcalfe, Prussin (bib55) 2003; 112
D'Alise (10.1016/j.jaci.2017.10.044_bib28) 2008; 105
Freeman (10.1016/j.jaci.2017.10.044_bib63) 1995; 2
Yao (10.1016/j.jaci.2017.10.044_bib67) 2010; 182
May (10.1016/j.jaci.2017.10.044_bib17) 2013; 354
Zhu (10.1016/j.jaci.2017.10.044_bib60) 1999; 103
Yao (10.1016/j.jaci.2017.10.044_bib24) 2010; 182
Geijtenbeek (10.1016/j.jaci.2017.10.044_bib41) 2016; 16
Casciano (10.1016/j.jaci.2017.10.044_bib54) 2016; 16
Yang (10.1016/j.jaci.2017.10.044_bib18) 2016; 13
Hodge (10.1016/j.jaci.2017.10.044_bib57) 2007; 37
Ishii (10.1016/j.jaci.2017.10.044_bib70) 2004; 172
Weckbach (10.1016/j.jaci.2017.10.044_bib14) 2014; 123
Pavord (10.1016/j.jaci.2017.10.044_bib32) 2012; 380
van Rijt (10.1016/j.jaci.2017.10.044_bib42) 2005; 201
Mishra (10.1016/j.jaci.2017.10.044_bibE1) 2015; 6
Overton (10.1016/j.jaci.2017.10.044_bib13) 2007; 100
Binder (10.1016/j.jaci.2017.10.044_bib20) 2000; 1
Pope (10.1016/j.jaci.2017.10.044_bib58) 2001; 108
Takayama (10.1016/j.jaci.2017.10.044_bib10) 2005; 280
Hammad (10.1016/j.jaci.2017.10.044_bib77) 2002; 169
Gardai (10.1016/j.jaci.2017.10.044_bib23) 2003; 115
Stumbles (10.1016/j.jaci.2017.10.044_bib43) 1998; 188
Lambrecht (10.1016/j.jaci.2017.10.044_bib73) 2014; 119
Hadeiba (10.1016/j.jaci.2017.10.044_bib62) 2003; 170
Hart (10.1016/j.jaci.2017.10.044_bib45) 2004; 172
Wilson (10.1016/j.jaci.2017.10.044_bib65) 2012; 18
Herz (10.1016/j.jaci.2017.10.044_bib1) 2001; 108
Bousquet (10.1016/j.jaci.2017.10.044_bib53) 1990; 323
Crimi (10.1016/j.jaci.2017.10.044_bib69) 1998; 157
Boucher (10.1016/j.jaci.2017.10.044_bib12) 2003; 300
Haldar (10.1016/j.jaci.2017.10.044_bib31) 2009; 360
De Filippo (10.1016/j.jaci.2017.10.044_bib46) 2008; 181
Cianciolo (10.1016/j.jaci.2017.10.044_bib50) 2001; 20
Haldar (10.1016/j.jaci.2017.10.044_bib72) 2009; 360
Zhang (10.1016/j.jaci.2017.10.044_bib34) 2014; 44
Clarke (10.1016/j.jaci.2017.10.044_bib39) 2014; 7
Gaultier (10.1016/j.jaci.2017.10.044_bib16) 2008; 111
Makela (10.1016/j.jaci.2017.10.044_bib71) 2000; 97
Gonias (10.1016/j.jaci.2017.10.044_bib8) 2014; 184
Pope (10.1016/j.jaci.2017.10.044_bib76) 2005; 280
Mantuano (10.1016/j.jaci.2017.10.044_bib7) 2016; 113
Corren (10.1016/j.jaci.2017.10.044_bib30) 2011; 365
Fredriksson (10.1016/j.jaci.2017.10.044_bib25) 2014; 192
Mould (10.1016/j.jaci.2017.10.044_bib59) 1997; 99
Ito (10.1016/j.jaci.2017.10.044_bib38) 2017; 198
Tobian (10.1016/j.jaci.2017.10.044_bib22) 2004; 172
Chu (10.1016/j.jaci.2017.10.044_bib49) 1994; 152
Mesnil (10.1016/j.jaci.2017.10.044_bib75) 2012; 7
Arron (10.1016/j.jaci.2017.10.044_bib35) 2015; 70
Plantinga (10.1016/j.jaci.2017.10.044_bib36) 2013; 38
Hancock (10.1016/j.jaci.2017.10.044_bib48) 2012; 129
Vabulas (10.1016/j.jaci.2017.10.044_bib47) 2002; 277
Foster (10.1016/j.jaci.2017.10.044_bib55) 2003; 112
Lillis (10.1016/j.jaci.2017.10.044_bib2) 2008; 88
Jaffar (10.1016/j.jaci.2017.10.044_bib61) 2004; 172
Kanekiyo (10.1016/j.jaci.2017.10.044_bib5) 2014; 6
Yao (10.1016/j.jaci.2017.10.044_bib68) 2013; 49
Hammad (10.1016/j.jaci.2017.10.044_bib44) 2010; 207
Pawaria (10.1016/j.jaci.2017.10.044_bib21) 2011; 2
Mishra (10.1016/j.jaci.2017.10.044_bib27) 2015; 6
Subramanian (10.1016/j.jaci.2017.10.044_bib19) 2014; 124
Wenzel (10.1016/j.jaci.2017.10.044_bib29) 2013; 368
Poynter (10.1016/j.jaci.2017.10.044_bib66) 2004; 173
Basu (10.1016/j.jaci.2017.10.044_bib52) 2000; 12
Hanania (10.1016/j.jaci.2017.10.044_bib33) 2013; 187
Tucker (10.1016/j.jaci.2017.10.044_bib9) 2012; 46
Figdor (10.1016/j.jaci.2017.10.044_bib40) 2002; 2
LaMarre (10.1016/j.jaci.2017.10.044_bib56) 1993; 91
May (10.1016/j.jaci.2017.10.044_bib15) 2013; 24
Song (10.1016/j.jaci.2017.10.044_bib11) 2009; 69
Medoff (10.1016/j.jaci.2017.10.044_bib37) 2009; 182
Dzionek (10.1016/j.jaci.2017.10.044_bib26) 2000; 165
Basu (10.1016/j.jaci.2017.10.044_bib51) 2001; 14
Boucher (10.1016/j.jaci.2017.10.044_bib6) 2011; 81
Gaultier (10.1016/j.jaci.2017.10.044_bib3) 2010; 29
Krieger (10.1016/j.jaci.2017.10.044_bib4) 1994; 63
Julia (10.1016/j.jaci.2017.10.044_bib74) 2002; 16
Masten (10.1016/j.jaci.2017.10.044_bib64) 1997; 16
References_xml – volume: 88
  start-page: 887
  year: 2008
  end-page: 918
  ident: bib2
  article-title: LDL receptor-related protein 1: Unique tissue-specific functions revealed by selective gene knockout studies
  publication-title: Physiol Rev
– volume: 170
  start-page: 5502
  year: 2003
  end-page: 5510
  ident: bib62
  article-title: Lung CD25 CD4 regulatory T cells suppress type 2 immune responses but not bronchial hyperreactivity
  publication-title: J Immunol
– volume: 16
  start-page: 271
  year: 2002
  end-page: 283
  ident: bib74
  article-title: A restricted subset of dendritic cells captures airborne antigens and remains able to activate specific T cells long after antigen exposure
  publication-title: Immunity
– volume: 280
  start-page: 13952
  year: 2005
  end-page: 13961
  ident: bib76
  article-title: Identification of a cooperative mechanism involving interleukin-13 and eotaxin-2 in experimental allergic lung inflammation
  publication-title: J Biol Chem
– volume: 184
  start-page: 18
  year: 2014
  end-page: 27
  ident: bib8
  article-title: LDL receptor-related protein-1: a regulator of inflammation in atherosclerosis, cancer, and injury to the nervous system
  publication-title: Am J Pathol
– volume: 198
  start-page: 61
  year: 2017
  end-page: 70
  ident: bib38
  article-title: Dectin-1 plays an important role in house dust mite-induced allergic airway inflammation through the activation of CD11b(+) dendritic cells
  publication-title: J Immunol
– volume: 20
  start-page: 554
  year: 2001
  end-page: 562
  ident: bib50
  article-title: Covalent complexes of antigen and alpha(2)-macroglobulin: evidence for dramatically-increased immunogenicity
  publication-title: Vaccine
– volume: 103
  start-page: 779
  year: 1999
  end-page: 788
  ident: bib60
  article-title: Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production
  publication-title: J Clin Invest
– volume: 38
  start-page: 322
  year: 2013
  end-page: 335
  ident: bib36
  article-title: Conventional and monocyte-derived CD11b(+) dendritic cells initiate and maintain T helper 2 cell-mediated immunity to house dust mite allergen
  publication-title: Immunity
– volume: 69
  start-page: 879
  year: 2009
  end-page: 886
  ident: bib11
  article-title: Low-density lipoprotein receptor-related protein 1 promotes cancer cell migration and invasion by inducing the expression of matrix metalloproteinases 2 and 9
  publication-title: Cancer Res
– volume: 44
  start-page: 1137
  year: 2014
  end-page: 1145
  ident: bib34
  article-title: Full blood count parameters for the detection of asthma inflammatory phenotypes
  publication-title: Clin Exp Allergy
– volume: 46
  start-page: 196
  year: 2012
  end-page: 206
  ident: bib9
  article-title: Lipoprotein receptor-related protein 1 regulates collagen 1 expression, proteolysis, and migration in human pleural mesothelial cells
  publication-title: Am J Respir Cell Mol Biol
– volume: 172
  start-page: 70
  year: 2004
  end-page: 78
  ident: bib45
  article-title: A CD91-positive subset of CD11c(+) blood dendritic cells: Characterization of the APC that functions to enhance adaptive immune responses against CD91-targeted antigens
  publication-title: J Immunol
– volume: 277
  start-page: 20847
  year: 2002
  end-page: 20853
  ident: bib47
  article-title: The endoplasmic reticulum-resident heat shock protein Gp96 activates dendritic cells via the toll-like receptor 2/4 pathway
  publication-title: J Biol Chem
– volume: 49
  start-page: 902
  year: 2013
  end-page: 911
  ident: bib68
  article-title: Peptidoglycan recognition protein 1 promotes house dust mite-induced airway inflammation in mice
  publication-title: Am J Respir Cell Mol Biol
– volume: 123
  start-page: 1887
  year: 2014
  end-page: 1896
  ident: bib14
  article-title: The cytokine midkine supports neutrophil trafficking during acute inflammation by promoting adhesion via beta(2) integrins (CD11/CD18)
  publication-title: Blood
– volume: 14
  start-page: 303
  year: 2001
  end-page: 313
  ident: bib51
  article-title: CD91 is a common receptor for heat shock proteins gp96, hsp90, hsp70, and calreticulin
  publication-title: Immunity
– volume: 169
  start-page: 1524
  year: 2002
  end-page: 1534
  ident: bib77
  article-title: Monocyte-derived dendritic cells induce a house dust mite-specific Th2 allergic inflammation in the lung of humanized SCID mice: involvement of CCR7
  publication-title: J Immunol
– volume: 192
  start-page: 4497
  year: 2014
  end-page: 4509
  ident: bib25
  article-title: The very low density lipoprotein receptor attenuates house dust mite-induced airway inflammation by suppressing dendritic cell-mediated adaptive immune responses
  publication-title: J Immunol
– volume: 111
  start-page: 5316
  year: 2008
  end-page: 5325
  ident: bib16
  article-title: Regulation of tumor necrosis factor receptor-1 and the IKK-NF-kappa B pathway by LDL receptor-related protein explains the antiinflammatory activity of this receptor
  publication-title: Blood
– volume: 113
  start-page: 1369
  year: 2016
  end-page: 1374
  ident: bib7
  article-title: LDL receptor-related protein-1 regulates NFκB and microRNA-155 in macrophages to control the inflammatory response
  publication-title: Proc Natl Acad Sci U S A
– volume: 105
  start-page: 19857
  year: 2008
  end-page: 19862
  ident: bib28
  article-title: The defect in T-cell regulation in NOD mice is an effect on the T-cell effectors
  publication-title: Proc Natl Acad Sci U S A
– volume: 173
  start-page: 7003
  year: 2004
  end-page: 7009
  ident: bib66
  article-title: NF-kappa B activation in airways modulates allergic inflammation but not hyperresponsiveness
  publication-title: J Immunol
– volume: 13
  start-page: 304
  year: 2016
  ident: bib18
  article-title: LRP1 modulates the microglial immune response via regulation of JNK and NF-κB signaling pathways
  publication-title: J Neuroinflammation
– volume: 157
  start-page: 4
  year: 1998
  end-page: 9
  ident: bib69
  article-title: Dissociation between airway inflammation and airway hyperresponsiveness in allergic asthma
  publication-title: Am J Respir Crit Care Med
– volume: 172
  start-page: 7095
  year: 2004
  end-page: 7102
  ident: bib70
  article-title: Platelet-activating factor receptor develops airway hyperresponsiveness independently of airway inflammation in a murine asthma model
  publication-title: J Immunol
– volume: 12
  start-page: 1539
  year: 2000
  end-page: 1546
  ident: bib52
  article-title: Necrotic but not apoptotic cell death releases heat shock proteins, which deliver a partial maturation signal to dendritic cells and activate the NF-kappa B pathway
  publication-title: Int Immunol
– volume: 1
  start-page: 151
  year: 2000
  end-page: 155
  ident: bib20
  article-title: CD91: a receptor for heat shock protein gp96
  publication-title: Nat Immunol
– volume: 124
  start-page: 1296
  year: 2014
  end-page: 1308
  ident: bib19
  article-title: An AXL/LRP-1/RANBP9 complex mediates DC efferocytosis and antigen cross-presentation in vivo
  publication-title: J Clin Invest
– volume: 323
  start-page: 1033
  year: 1990
  end-page: 1039
  ident: bib53
  article-title: Eosinophilic inflammation in asthma
  publication-title: N Engl J Med
– volume: 81
  start-page: 1
  year: 2011
  end-page: 5
  ident: bib6
  article-title: Signaling through LRP1: protection from atherosclerosis and beyond
  publication-title: Biochem Pharmacol
– volume: 115
  start-page: 13
  year: 2003
  end-page: 23
  ident: bib23
  article-title: By binding SIRP alpha or calreticulin/CD91, lung collectins act as dual function surveillance molecules to suppress or enhance inflammation
  publication-title: Cell
– volume: 112
  start-page: 1132
  year: 2003
  end-page: 1138
  ident: bib55
  article-title: Human dendritic cell 1 and dendritic cell 2 subsets express FcεRI: correlation with serum IgE and allergic asthma
  publication-title: J Allergy Clin Immunol
– volume: 63
  start-page: 601
  year: 1994
  end-page: 637
  ident: bib4
  article-title: Structures and functions of multiligand lipoprotein receptors: macrophage scavenger receptors and LDL receptor-related protein (Lrp)
  publication-title: Annu Rev Biochem
– volume: 165
  start-page: 6037
  year: 2000
  end-page: 6046
  ident: bib26
  article-title: BDCA-2, BDCA-3 and BDCA-4: Three markers for distinct subsets of dendritic cells in human peripheral blood
  publication-title: J Immunol
– volume: 354
  start-page: 887
  year: 2013
  end-page: 889
  ident: bib17
  article-title: Low density receptor-related protein 1 (LRP1) promotes anti-inflammatory phenotype in murine macrophages
  publication-title: Cell Tissue Res
– volume: 91
  start-page: 1219
  year: 1993
  end-page: 1224
  ident: bib56
  article-title: Regulation of macrophage alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein by lipopolysaccharide and interferon-gamma
  publication-title: J Clin Invest
– volume: 172
  start-page: 3842
  year: 2004
  end-page: 3849
  ident: bib61
  article-title: CD4(+)CD25(+) T cells regulate airway eosinophilic inflammation by modulating the Th2 cell phenotype
  publication-title: J Immunol
– volume: 2
  start-page: 521
  year: 2011
  ident: bib21
  article-title: CD91-dependent programming of T-helper cell responses following heat shock protein immunization
  publication-title: Nat Commun
– volume: 16
  start-page: 433
  year: 2016
  end-page: 448
  ident: bib41
  article-title: C-type lectin receptors in the control of T helper cell differentiation
  publication-title: Nat Rev Immunol
– volume: 360
  start-page: 973
  year: 2009
  end-page: 984
  ident: bib72
  article-title: Mepolizumab and exacerbations of refractory eosinophilic asthma
  publication-title: N Engl J Med
– volume: 6
  start-page: 6224
  year: 2015
  ident: bib27
  article-title: Dendritic cells induce Th2-mediated airway inflammatory responses to house dust mite via DNA-dependent protein kinase
  publication-title: Nat Commun
– volume: 16
  start-page: 100
  year: 2016
  ident: bib54
  article-title: Burden of asthma with elevated blood eosinophil levels
  publication-title: BMC Pulm Med
– volume: 108
  start-page: 594
  year: 2001
  end-page: 601
  ident: bib58
  article-title: IL-13 induces eosinophil recruitment into the lung by an IL-5-and eotaxin-dependent mechanism
  publication-title: J Allergy Clin Immunol
– volume: 7
  start-page: e53242
  year: 2012
  ident: bib75
  article-title: Resident CD11b(+)Ly6C(−) lung dendritic cells are responsible for allergic airway sensitization to house dust mite in mice
  publication-title: PLos One
– volume: 99
  start-page: 1064
  year: 1997
  end-page: 1071
  ident: bib59
  article-title: Relationship between interleukin-5 and eotaxin in regulating blood and tissue eosinophilia in mice
  publication-title: J Clin Invest
– volume: 182
  start-page: 1228
  year: 2010
  end-page: 1238
  ident: bib24
  article-title: Apolipoprotein E negatively regulates house dust mite-induced asthma via a low-density lipoprotein receptor-mediated pathway
  publication-title: Am J Respir Crit Care Med
– volume: 201
  start-page: 981
  year: 2005
  end-page: 991
  ident: bib42
  article-title: In vivo depletion of lung CD11c(+) dendritic cells during allergen challenge abrogates the characteristic features of asthma
  publication-title: J Exp Med
– volume: 29
  start-page: 22
  year: 2010
  end-page: 30
  ident: bib3
  article-title: LRP1 regulates remodeling of the extracellular matrix by fibroblasts
  publication-title: Matrix Biol
– volume: 368
  start-page: 2455
  year: 2013
  end-page: 2466
  ident: bib29
  article-title: Dupilumab in persistent asthma with elevated eosinophil levels
  publication-title: N Engl J Med
– volume: 207
  start-page: 2097
  year: 2010
  end-page: 2111
  ident: bib44
  article-title: Inflammatory dendritic cells-not basophils-are necessary and sufficient for induction of Th2 immunity to inhaled house dust mite allergen
  publication-title: J Exp Med
– volume: 37
  start-page: 748
  year: 2007
  end-page: 755
  ident: bib57
  article-title: Smoking alters alveolar macrophage recognition and phagocytic ability
  publication-title: Am J Respir Cell Mol Biol
– volume: 360
  start-page: 973
  year: 2009
  end-page: 984
  ident: bib31
  article-title: Mepolizumab and exacerbations of refractory eosinophilic asthma
  publication-title: N Engl J Med
– volume: 100
  start-page: 670
  year: 2007
  end-page: 677
  ident: bib13
  article-title: Deletion of macrophage LDL receptor-related protein increases atherogenesis in the mouse
  publication-title: Circ Res
– volume: 187
  start-page: 804
  year: 2013
  end-page: 811
  ident: bib33
  article-title: Exploring the effects of omalizumab in allergic asthma: an analysis of biomarkers in the EXTRA study
  publication-title: Am J Respir Crit Care Med
– volume: 172
  start-page: 5277
  year: 2004
  end-page: 5286
  ident: bib22
  article-title: Bacterial heat shock proteins promote CD91-dependent class I MHC cross-presentation of chaperoned peptide to CD8+ T cells by cytosolic mechanisms in dendritic cells versus vacuolar mechanisms in macrophages
  publication-title: J Immunol
– volume: 70
  start-page: 105
  year: 2015
  end-page: 107
  ident: bib35
  article-title: Asthma biomarkers: what constitutes a ‘gold standard’?
  publication-title: Thorax
– volume: 181
  start-page: 6525
  year: 2008
  end-page: 6535
  ident: bib46
  article-title: Human plasmacytoid dendritic cells interact with gp96 via CD91 and regulate inflammatory responses
  publication-title: J Immunol
– volume: 380
  start-page: 651
  year: 2012
  end-page: 659
  ident: bib32
  article-title: Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial
  publication-title: Lancet
– volume: 16
  start-page: 335
  year: 1997
  end-page: 342
  ident: bib64
  article-title: Characterization of accessory molecules in murine lung dendritic cell function: roles for CD80, CD86, CD54, and CD40L
  publication-title: Am J Respir Cell Mol Biol
– volume: 18
  start-page: 1705
  year: 2012
  end-page: 1710
  ident: bib65
  article-title: The Toll-like receptor 5 ligand flagellin promotes asthma by priming allergic responses to indoor allergens
  publication-title: Nat Med
– volume: 2
  start-page: 77
  year: 2002
  end-page: 84
  ident: bib40
  article-title: C-type lectin receptors on dendritic cells and Langerhans cells
  publication-title: Nat Rev Immunol
– volume: 152
  start-page: 1538
  year: 1994
  end-page: 1545
  ident: bib49
  article-title: Adjuvant-free in-vivo targeting. Antigen delivery by alpha 2-macroglobulin enhances antibody formation
  publication-title: J Immunol
– volume: 119
  start-page: S236
  year: 2014
  end-page: S243
  ident: bib73
  article-title: Dendritic cell and epithelial cell interactions at the origin of murine asthma
  publication-title: Ann Am Thorac Soc
– volume: 2
  start-page: 523
  year: 1995
  end-page: 532
  ident: bib63
  article-title: B7-1 and B7-2 do not deliver identical costimulatory signals, since B7-2 but not B7-1 preferentially costimulates the initial production of IL-4
  publication-title: Immunity
– volume: 108
  start-page: 779
  year: 2001
  end-page: 784
  ident: bib1
  article-title: LRP: a multifunctional scavenger and signaling receptor
  publication-title: J Clin Invest
– volume: 24
  start-page: 134
  year: 2013
  end-page: 137
  ident: bib15
  article-title: The low-density lipoprotein receptor-related protein 1 in inflammation
  publication-title: Curr Opin Lipidol
– volume: 97
  start-page: 6007
  year: 2000
  end-page: 6012
  ident: bib71
  article-title: IL-10 is necessary for the expression of airway hyperresponsiveness but not pulmonary inflammation after allergic sensitization
  publication-title: Proc Natl Acad Sci U S A
– volume: 182
  start-page: 623
  year: 2009
  end-page: 635
  ident: bib37
  article-title: CD11b(+) Myeloid cells are the key mediators of Th2 cell homing into the airway in allergic inflammation
  publication-title: J Immunol
– volume: 7
  start-page: 558
  year: 2014
  end-page: 567
  ident: bib39
  article-title: Dectin-2 sensing of house dust mite is critical for the initiation of airway inflammation
  publication-title: Mucosal Immunol
– volume: 182
  start-page: 1228
  year: 2010
  end-page: 1238
  ident: bib67
  article-title: Apolipoprotein E negatively regulates house dust mite-induced asthma via a low-density lipoprotein receptor-mediated pathway
  publication-title: Am J Respir Crit Care Med
– volume: 129
  start-page: 1673
  year: 2012
  end-page: 1676
  ident: bib48
  article-title: STAT6 and LRP1 polymorphisms are associated with food allergen sensitization in Mexican children
  publication-title: J Allergy Clin Immunol
– volume: 365
  start-page: 1088
  year: 2011
  end-page: 1098
  ident: bib30
  article-title: Lebrikizumab treatment in adults with asthma
  publication-title: N Engl J Med
– volume: 280
  start-page: 18504
  year: 2005
  end-page: 18510
  ident: bib10
  article-title: Low density lipoprotein receptor-related protein 1 (LRP1) controls endocytosis and c-CBL-mediated ubiquitination of the platelet-derived growth factor receptor beta (PDGFR beta)
  publication-title: J Biol Chem
– volume: 6
  start-page: 93
  year: 2014
  ident: bib5
  article-title: The low-density lipoprotein receptor-related protein 1 and amyloid-beta clearance in Alzheimer's disease
  publication-title: Front Aging Neurosci
– volume: 300
  start-page: 329
  year: 2003
  end-page: 332
  ident: bib12
  article-title: LRP: Role in vascular wall integrity and protection from atherosclerosis
  publication-title: Science
– volume: 188
  start-page: 2019
  year: 1998
  end-page: 2031
  ident: bib43
  article-title: Resting respiratory tract dendritic cells preferentially stimulate T helper cell type 2 (Th2) responses and require obligatory cytokine signals for induction of Th1 immunity
  publication-title: J Exp Med
– volume: 70
  start-page: 105
  year: 2015
  ident: 10.1016/j.jaci.2017.10.044_bib35
  article-title: Asthma biomarkers: what constitutes a ‘gold standard’?
  publication-title: Thorax
  doi: 10.1136/thoraxjnl-2014-206069
– volume: 184
  start-page: 18
  year: 2014
  ident: 10.1016/j.jaci.2017.10.044_bib8
  article-title: LDL receptor-related protein-1: a regulator of inflammation in atherosclerosis, cancer, and injury to the nervous system
  publication-title: Am J Pathol
  doi: 10.1016/j.ajpath.2013.08.029
– volume: 172
  start-page: 7095
  year: 2004
  ident: 10.1016/j.jaci.2017.10.044_bib70
  article-title: Platelet-activating factor receptor develops airway hyperresponsiveness independently of airway inflammation in a murine asthma model
  publication-title: J Immunol
  doi: 10.4049/jimmunol.172.11.7095
– volume: 172
  start-page: 70
  year: 2004
  ident: 10.1016/j.jaci.2017.10.044_bib45
  article-title: A CD91-positive subset of CD11c(+) blood dendritic cells: Characterization of the APC that functions to enhance adaptive immune responses against CD91-targeted antigens
  publication-title: J Immunol
  doi: 10.4049/jimmunol.172.1.70
– volume: 99
  start-page: 1064
  year: 1997
  ident: 10.1016/j.jaci.2017.10.044_bib59
  article-title: Relationship between interleukin-5 and eotaxin in regulating blood and tissue eosinophilia in mice
  publication-title: J Clin Invest
  doi: 10.1172/JCI119234
– volume: 170
  start-page: 5502
  year: 2003
  ident: 10.1016/j.jaci.2017.10.044_bib62
  article-title: Lung CD25 CD4 regulatory T cells suppress type 2 immune responses but not bronchial hyperreactivity
  publication-title: J Immunol
  doi: 10.4049/jimmunol.170.11.5502
– volume: 6
  start-page: 93
  year: 2014
  ident: 10.1016/j.jaci.2017.10.044_bib5
  article-title: The low-density lipoprotein receptor-related protein 1 and amyloid-beta clearance in Alzheimer's disease
  publication-title: Front Aging Neurosci
  doi: 10.3389/fnagi.2014.00093
– volume: 63
  start-page: 601
  year: 1994
  ident: 10.1016/j.jaci.2017.10.044_bib4
  article-title: Structures and functions of multiligand lipoprotein receptors: macrophage scavenger receptors and LDL receptor-related protein (Lrp)
  publication-title: Annu Rev Biochem
  doi: 10.1146/annurev.bi.63.070194.003125
– volume: 13
  start-page: 304
  year: 2016
  ident: 10.1016/j.jaci.2017.10.044_bib18
  article-title: LRP1 modulates the microglial immune response via regulation of JNK and NF-κB signaling pathways
  publication-title: J Neuroinflammation
  doi: 10.1186/s12974-016-0772-7
– volume: 37
  start-page: 748
  year: 2007
  ident: 10.1016/j.jaci.2017.10.044_bib57
  article-title: Smoking alters alveolar macrophage recognition and phagocytic ability
  publication-title: Am J Respir Cell Mol Biol
  doi: 10.1165/rcmb.2007-0025OC
– volume: 123
  start-page: 1887
  year: 2014
  ident: 10.1016/j.jaci.2017.10.044_bib14
  article-title: The cytokine midkine supports neutrophil trafficking during acute inflammation by promoting adhesion via beta(2) integrins (CD11/CD18)
  publication-title: Blood
  doi: 10.1182/blood-2013-06-510875
– volume: 12
  start-page: 1539
  year: 2000
  ident: 10.1016/j.jaci.2017.10.044_bib52
  article-title: Necrotic but not apoptotic cell death releases heat shock proteins, which deliver a partial maturation signal to dendritic cells and activate the NF-kappa B pathway
  publication-title: Int Immunol
  doi: 10.1093/intimm/12.11.1539
– volume: 207
  start-page: 2097
  year: 2010
  ident: 10.1016/j.jaci.2017.10.044_bib44
  article-title: Inflammatory dendritic cells-not basophils-are necessary and sufficient for induction of Th2 immunity to inhaled house dust mite allergen
  publication-title: J Exp Med
  doi: 10.1084/jem.20101563
– volume: 277
  start-page: 20847
  year: 2002
  ident: 10.1016/j.jaci.2017.10.044_bib47
  article-title: The endoplasmic reticulum-resident heat shock protein Gp96 activates dendritic cells via the toll-like receptor 2/4 pathway
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M200425200
– volume: 2
  start-page: 77
  year: 2002
  ident: 10.1016/j.jaci.2017.10.044_bib40
  article-title: C-type lectin receptors on dendritic cells and Langerhans cells
  publication-title: Nat Rev Immunol
  doi: 10.1038/nri723
– volume: 173
  start-page: 7003
  year: 2004
  ident: 10.1016/j.jaci.2017.10.044_bib66
  article-title: NF-kappa B activation in airways modulates allergic inflammation but not hyperresponsiveness
  publication-title: J Immunol
  doi: 10.4049/jimmunol.173.11.7003
– volume: 198
  start-page: 61
  year: 2017
  ident: 10.1016/j.jaci.2017.10.044_bib38
  article-title: Dectin-1 plays an important role in house dust mite-induced allergic airway inflammation through the activation of CD11b(+) dendritic cells
  publication-title: J Immunol
  doi: 10.4049/jimmunol.1502393
– volume: 360
  start-page: 973
  year: 2009
  ident: 10.1016/j.jaci.2017.10.044_bib72
  article-title: Mepolizumab and exacerbations of refractory eosinophilic asthma
  publication-title: N Engl J Med
  doi: 10.1056/NEJMoa0808991
– volume: 368
  start-page: 2455
  year: 2013
  ident: 10.1016/j.jaci.2017.10.044_bib29
  article-title: Dupilumab in persistent asthma with elevated eosinophil levels
  publication-title: N Engl J Med
  doi: 10.1056/NEJMoa1304048
– volume: 157
  start-page: 4
  year: 1998
  ident: 10.1016/j.jaci.2017.10.044_bib69
  article-title: Dissociation between airway inflammation and airway hyperresponsiveness in allergic asthma
  publication-title: Am J Respir Crit Care Med
  doi: 10.1164/ajrccm.157.1.9703002
– volume: 108
  start-page: 594
  year: 2001
  ident: 10.1016/j.jaci.2017.10.044_bib58
  article-title: IL-13 induces eosinophil recruitment into the lung by an IL-5-and eotaxin-dependent mechanism
  publication-title: J Allergy Clin Immunol
  doi: 10.1067/mai.2001.118600
– volume: 29
  start-page: 22
  year: 2010
  ident: 10.1016/j.jaci.2017.10.044_bib3
  article-title: LRP1 regulates remodeling of the extracellular matrix by fibroblasts
  publication-title: Matrix Biol
  doi: 10.1016/j.matbio.2009.08.003
– volume: 172
  start-page: 3842
  year: 2004
  ident: 10.1016/j.jaci.2017.10.044_bib61
  article-title: CD4(+)CD25(+) T cells regulate airway eosinophilic inflammation by modulating the Th2 cell phenotype
  publication-title: J Immunol
  doi: 10.4049/jimmunol.172.6.3842
– volume: 201
  start-page: 981
  year: 2005
  ident: 10.1016/j.jaci.2017.10.044_bib42
  article-title: In vivo depletion of lung CD11c(+) dendritic cells during allergen challenge abrogates the characteristic features of asthma
  publication-title: J Exp Med
  doi: 10.1084/jem.20042311
– volume: 172
  start-page: 5277
  year: 2004
  ident: 10.1016/j.jaci.2017.10.044_bib22
  article-title: Bacterial heat shock proteins promote CD91-dependent class I MHC cross-presentation of chaperoned peptide to CD8+ T cells by cytosolic mechanisms in dendritic cells versus vacuolar mechanisms in macrophages
  publication-title: J Immunol
  doi: 10.4049/jimmunol.172.9.5277
– volume: 16
  start-page: 335
  year: 1997
  ident: 10.1016/j.jaci.2017.10.044_bib64
  article-title: Characterization of accessory molecules in murine lung dendritic cell function: roles for CD80, CD86, CD54, and CD40L
  publication-title: Am J Respir Cell Mol Biol
  doi: 10.1165/ajrcmb.16.3.9070619
– volume: 1
  start-page: 151
  year: 2000
  ident: 10.1016/j.jaci.2017.10.044_bib20
  article-title: CD91: a receptor for heat shock protein gp96
  publication-title: Nat Immunol
  doi: 10.1038/77835
– volume: 365
  start-page: 1088
  year: 2011
  ident: 10.1016/j.jaci.2017.10.044_bib30
  article-title: Lebrikizumab treatment in adults with asthma
  publication-title: N Engl J Med
  doi: 10.1056/NEJMoa1106469
– volume: 360
  start-page: 973
  year: 2009
  ident: 10.1016/j.jaci.2017.10.044_bib31
  article-title: Mepolizumab and exacerbations of refractory eosinophilic asthma
  publication-title: N Engl J Med
  doi: 10.1056/NEJMoa0808991
– volume: 182
  start-page: 1228
  year: 2010
  ident: 10.1016/j.jaci.2017.10.044_bib67
  article-title: Apolipoprotein E negatively regulates house dust mite-induced asthma via a low-density lipoprotein receptor-mediated pathway
  publication-title: Am J Respir Crit Care Med
  doi: 10.1164/rccm.201002-0308OC
– volume: 7
  start-page: e53242
  year: 2012
  ident: 10.1016/j.jaci.2017.10.044_bib75
  article-title: Resident CD11b(+)Ly6C(−) lung dendritic cells are responsible for allergic airway sensitization to house dust mite in mice
  publication-title: PLos One
  doi: 10.1371/journal.pone.0053242
– volume: 188
  start-page: 2019
  year: 1998
  ident: 10.1016/j.jaci.2017.10.044_bib43
  article-title: Resting respiratory tract dendritic cells preferentially stimulate T helper cell type 2 (Th2) responses and require obligatory cytokine signals for induction of Th1 immunity
  publication-title: J Exp Med
  doi: 10.1084/jem.188.11.2019
– volume: 69
  start-page: 879
  year: 2009
  ident: 10.1016/j.jaci.2017.10.044_bib11
  article-title: Low-density lipoprotein receptor-related protein 1 promotes cancer cell migration and invasion by inducing the expression of matrix metalloproteinases 2 and 9
  publication-title: Cancer Res
  doi: 10.1158/0008-5472.CAN-08-3379
– volume: 46
  start-page: 196
  year: 2012
  ident: 10.1016/j.jaci.2017.10.044_bib9
  article-title: Lipoprotein receptor-related protein 1 regulates collagen 1 expression, proteolysis, and migration in human pleural mesothelial cells
  publication-title: Am J Respir Cell Mol Biol
  doi: 10.1165/rcmb.2011-0071OC
– volume: 300
  start-page: 329
  year: 2003
  ident: 10.1016/j.jaci.2017.10.044_bib12
  article-title: LRP: Role in vascular wall integrity and protection from atherosclerosis
  publication-title: Science
  doi: 10.1126/science.1082095
– volume: 6
  start-page: 6224
  year: 2015
  ident: 10.1016/j.jaci.2017.10.044_bibE1
  article-title: Dendritic cells induce Th2-mediated airway inflammatory responses to house dust mite via DNA-dependent protein kinase
  publication-title: Nat Commun
  doi: 10.1038/ncomms7224
– volume: 49
  start-page: 902
  year: 2013
  ident: 10.1016/j.jaci.2017.10.044_bib68
  article-title: Peptidoglycan recognition protein 1 promotes house dust mite-induced airway inflammation in mice
  publication-title: Am J Respir Cell Mol Biol
  doi: 10.1165/rcmb.2013-0001OC
– volume: 354
  start-page: 887
  year: 2013
  ident: 10.1016/j.jaci.2017.10.044_bib17
  article-title: Low density receptor-related protein 1 (LRP1) promotes anti-inflammatory phenotype in murine macrophages
  publication-title: Cell Tissue Res
  doi: 10.1007/s00441-013-1699-2
– volume: 14
  start-page: 303
  year: 2001
  ident: 10.1016/j.jaci.2017.10.044_bib51
  article-title: CD91 is a common receptor for heat shock proteins gp96, hsp90, hsp70, and calreticulin
  publication-title: Immunity
  doi: 10.1016/S1074-7613(01)00111-X
– volume: 119
  start-page: S236
  issue: suppl 5
  year: 2014
  ident: 10.1016/j.jaci.2017.10.044_bib73
  article-title: Dendritic cell and epithelial cell interactions at the origin of murine asthma
  publication-title: Ann Am Thorac Soc
  doi: 10.1513/AnnalsATS.201405-218AW
– volume: 20
  start-page: 554
  year: 2001
  ident: 10.1016/j.jaci.2017.10.044_bib50
  article-title: Covalent complexes of antigen and alpha(2)-macroglobulin: evidence for dramatically-increased immunogenicity
  publication-title: Vaccine
  doi: 10.1016/S0264-410X(01)00361-9
– volume: 280
  start-page: 13952
  year: 2005
  ident: 10.1016/j.jaci.2017.10.044_bib76
  article-title: Identification of a cooperative mechanism involving interleukin-13 and eotaxin-2 in experimental allergic lung inflammation
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M406037200
– volume: 152
  start-page: 1538
  year: 1994
  ident: 10.1016/j.jaci.2017.10.044_bib49
  article-title: Adjuvant-free in-vivo targeting. Antigen delivery by alpha 2-macroglobulin enhances antibody formation
  publication-title: J Immunol
  doi: 10.4049/jimmunol.152.4.1538
– volume: 100
  start-page: 670
  year: 2007
  ident: 10.1016/j.jaci.2017.10.044_bib13
  article-title: Deletion of macrophage LDL receptor-related protein increases atherogenesis in the mouse
  publication-title: Circ Res
  doi: 10.1161/01.RES.0000260204.40510.aa
– volume: 24
  start-page: 134
  year: 2013
  ident: 10.1016/j.jaci.2017.10.044_bib15
  article-title: The low-density lipoprotein receptor-related protein 1 in inflammation
  publication-title: Curr Opin Lipidol
  doi: 10.1097/MOL.0b013e32835e809c
– volume: 88
  start-page: 887
  year: 2008
  ident: 10.1016/j.jaci.2017.10.044_bib2
  article-title: LDL receptor-related protein 1: Unique tissue-specific functions revealed by selective gene knockout studies
  publication-title: Physiol Rev
  doi: 10.1152/physrev.00033.2007
– volume: 129
  start-page: 1673
  year: 2012
  ident: 10.1016/j.jaci.2017.10.044_bib48
  article-title: STAT6 and LRP1 polymorphisms are associated with food allergen sensitization in Mexican children
  publication-title: J Allergy Clin Immunol
  doi: 10.1016/j.jaci.2012.03.012
– volume: 16
  start-page: 271
  year: 2002
  ident: 10.1016/j.jaci.2017.10.044_bib74
  article-title: A restricted subset of dendritic cells captures airborne antigens and remains able to activate specific T cells long after antigen exposure
  publication-title: Immunity
  doi: 10.1016/S1074-7613(02)00276-5
– volume: 112
  start-page: 1132
  year: 2003
  ident: 10.1016/j.jaci.2017.10.044_bib55
  article-title: Human dendritic cell 1 and dendritic cell 2 subsets express FcεRI: correlation with serum IgE and allergic asthma
  publication-title: J Allergy Clin Immunol
  doi: 10.1016/j.jaci.2003.09.011
– volume: 380
  start-page: 651
  year: 2012
  ident: 10.1016/j.jaci.2017.10.044_bib32
  article-title: Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial
  publication-title: Lancet
  doi: 10.1016/S0140-6736(12)60988-X
– volume: 182
  start-page: 623
  year: 2009
  ident: 10.1016/j.jaci.2017.10.044_bib37
  article-title: CD11b(+) Myeloid cells are the key mediators of Th2 cell homing into the airway in allergic inflammation
  publication-title: J Immunol
  doi: 10.4049/jimmunol.182.1.623
– volume: 124
  start-page: 1296
  year: 2014
  ident: 10.1016/j.jaci.2017.10.044_bib19
  article-title: An AXL/LRP-1/RANBP9 complex mediates DC efferocytosis and antigen cross-presentation in vivo
  publication-title: J Clin Invest
  doi: 10.1172/JCI72051
– volume: 81
  start-page: 1
  year: 2011
  ident: 10.1016/j.jaci.2017.10.044_bib6
  article-title: Signaling through LRP1: protection from atherosclerosis and beyond
  publication-title: Biochem Pharmacol
  doi: 10.1016/j.bcp.2010.09.018
– volume: 16
  start-page: 100
  year: 2016
  ident: 10.1016/j.jaci.2017.10.044_bib54
  article-title: Burden of asthma with elevated blood eosinophil levels
  publication-title: BMC Pulm Med
  doi: 10.1186/s12890-016-0263-8
– volume: 97
  start-page: 6007
  year: 2000
  ident: 10.1016/j.jaci.2017.10.044_bib71
  article-title: IL-10 is necessary for the expression of airway hyperresponsiveness but not pulmonary inflammation after allergic sensitization
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.100118997
– volume: 169
  start-page: 1524
  year: 2002
  ident: 10.1016/j.jaci.2017.10.044_bib77
  article-title: Monocyte-derived dendritic cells induce a house dust mite-specific Th2 allergic inflammation in the lung of humanized SCID mice: involvement of CCR7
  publication-title: J Immunol
  doi: 10.4049/jimmunol.169.3.1524
– volume: 6
  start-page: 6224
  year: 2015
  ident: 10.1016/j.jaci.2017.10.044_bib27
  article-title: Dendritic cells induce Th2-mediated airway inflammatory responses to house dust mite via DNA-dependent protein kinase
  publication-title: Nat Commun
  doi: 10.1038/ncomms7224
– volume: 323
  start-page: 1033
  year: 1990
  ident: 10.1016/j.jaci.2017.10.044_bib53
  article-title: Eosinophilic inflammation in asthma
  publication-title: N Engl J Med
  doi: 10.1056/NEJM199010113231505
– volume: 18
  start-page: 1705
  year: 2012
  ident: 10.1016/j.jaci.2017.10.044_bib65
  article-title: The Toll-like receptor 5 ligand flagellin promotes asthma by priming allergic responses to indoor allergens
  publication-title: Nat Med
  doi: 10.1038/nm.2920
– volume: 113
  start-page: 1369
  year: 2016
  ident: 10.1016/j.jaci.2017.10.044_bib7
  article-title: LDL receptor-related protein-1 regulates NFκB and microRNA-155 in macrophages to control the inflammatory response
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.1515480113
– volume: 2
  start-page: 523
  year: 1995
  ident: 10.1016/j.jaci.2017.10.044_bib63
  article-title: B7-1 and B7-2 do not deliver identical costimulatory signals, since B7-2 but not B7-1 preferentially costimulates the initial production of IL-4
  publication-title: Immunity
  doi: 10.1016/1074-7613(95)90032-2
– volume: 111
  start-page: 5316
  year: 2008
  ident: 10.1016/j.jaci.2017.10.044_bib16
  article-title: Regulation of tumor necrosis factor receptor-1 and the IKK-NF-kappa B pathway by LDL receptor-related protein explains the antiinflammatory activity of this receptor
  publication-title: Blood
  doi: 10.1182/blood-2007-12-127613
– volume: 38
  start-page: 322
  year: 2013
  ident: 10.1016/j.jaci.2017.10.044_bib36
  article-title: Conventional and monocyte-derived CD11b(+) dendritic cells initiate and maintain T helper 2 cell-mediated immunity to house dust mite allergen
  publication-title: Immunity
  doi: 10.1016/j.immuni.2012.10.016
– volume: 2
  start-page: 521
  year: 2011
  ident: 10.1016/j.jaci.2017.10.044_bib21
  article-title: CD91-dependent programming of T-helper cell responses following heat shock protein immunization
  publication-title: Nat Commun
  doi: 10.1038/ncomms1524
– volume: 44
  start-page: 1137
  year: 2014
  ident: 10.1016/j.jaci.2017.10.044_bib34
  article-title: Full blood count parameters for the detection of asthma inflammatory phenotypes
  publication-title: Clin Exp Allergy
  doi: 10.1111/cea.12345
– volume: 280
  start-page: 18504
  year: 2005
  ident: 10.1016/j.jaci.2017.10.044_bib10
  article-title: Low density lipoprotein receptor-related protein 1 (LRP1) controls endocytosis and c-CBL-mediated ubiquitination of the platelet-derived growth factor receptor beta (PDGFR beta)
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M410265200
– volume: 187
  start-page: 804
  year: 2013
  ident: 10.1016/j.jaci.2017.10.044_bib33
  article-title: Exploring the effects of omalizumab in allergic asthma: an analysis of biomarkers in the EXTRA study
  publication-title: Am J Respir Crit Care Med
  doi: 10.1164/rccm.201208-1414OC
– volume: 105
  start-page: 19857
  year: 2008
  ident: 10.1016/j.jaci.2017.10.044_bib28
  article-title: The defect in T-cell regulation in NOD mice is an effect on the T-cell effectors
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.0810713105
– volume: 115
  start-page: 13
  year: 2003
  ident: 10.1016/j.jaci.2017.10.044_bib23
  article-title: By binding SIRP alpha or calreticulin/CD91, lung collectins act as dual function surveillance molecules to suppress or enhance inflammation
  publication-title: Cell
  doi: 10.1016/S0092-8674(03)00758-X
– volume: 181
  start-page: 6525
  year: 2008
  ident: 10.1016/j.jaci.2017.10.044_bib46
  article-title: Human plasmacytoid dendritic cells interact with gp96 via CD91 and regulate inflammatory responses
  publication-title: J Immunol
  doi: 10.4049/jimmunol.181.9.6525
– volume: 192
  start-page: 4497
  year: 2014
  ident: 10.1016/j.jaci.2017.10.044_bib25
  article-title: The very low density lipoprotein receptor attenuates house dust mite-induced airway inflammation by suppressing dendritic cell-mediated adaptive immune responses
  publication-title: J Immunol
  doi: 10.4049/jimmunol.1301234
– volume: 103
  start-page: 779
  year: 1999
  ident: 10.1016/j.jaci.2017.10.044_bib60
  article-title: Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production
  publication-title: J Clin Invest
  doi: 10.1172/JCI5909
– volume: 91
  start-page: 1219
  year: 1993
  ident: 10.1016/j.jaci.2017.10.044_bib56
  article-title: Regulation of macrophage alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein by lipopolysaccharide and interferon-gamma
  publication-title: J Clin Invest
  doi: 10.1172/JCI116283
– volume: 182
  start-page: 1228
  year: 2010
  ident: 10.1016/j.jaci.2017.10.044_bib24
  article-title: Apolipoprotein E negatively regulates house dust mite-induced asthma via a low-density lipoprotein receptor-mediated pathway
  publication-title: Am J Respir Crit Care Med
  doi: 10.1164/rccm.201002-0308OC
– volume: 16
  start-page: 433
  year: 2016
  ident: 10.1016/j.jaci.2017.10.044_bib41
  article-title: C-type lectin receptors in the control of T helper cell differentiation
  publication-title: Nat Rev Immunol
  doi: 10.1038/nri.2016.55
– volume: 108
  start-page: 779
  year: 2001
  ident: 10.1016/j.jaci.2017.10.044_bib1
  article-title: LRP: a multifunctional scavenger and signaling receptor
  publication-title: J Clin Invest
  doi: 10.1172/JCI200113992
– volume: 165
  start-page: 6037
  year: 2000
  ident: 10.1016/j.jaci.2017.10.044_bib26
  article-title: BDCA-2, BDCA-3 and BDCA-4: Three markers for distinct subsets of dendritic cells in human peripheral blood
  publication-title: J Immunol
  doi: 10.4049/jimmunol.165.11.6037
– volume: 7
  start-page: 558
  year: 2014
  ident: 10.1016/j.jaci.2017.10.044_bib39
  article-title: Dectin-2 sensing of house dust mite is critical for the initiation of airway inflammation
  publication-title: Mucosal Immunol
  doi: 10.1038/mi.2013.74
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Snippet Low-density lipoprotein receptor–related protein 1 (LRP-1) is a scavenger receptor that regulates adaptive immunity and inflammation. LRP-1 is not known to...
Low-density lipoprotein receptor-related protein 1 (LRP-1) is a scavenger receptor that regulates adaptive immunity and inflammation. LRP-1 is not known to...
BackgroundLow-density lipoprotein receptor–related protein 1 (LRP-1) is a scavenger receptor that regulates adaptive immunity and inflammation. LRP-1 is not...
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SubjectTerms Adaptive Immunity
Adoptive transfer
Adult
Allergens - immunology
Allergies
Animals
Antigen presentation
Antigens, Dermatophagoides - immunology
Apolipoproteins
Asthma
Asthma - blood
Asthma - immunology
Asthma - physiopathology
Bone marrow
Bronchoalveolar Lavage Fluid - cytology
CD11b antigen
CD11c antigen
Clonal deletion
Cloning
Dendritic cells
Dendritic Cells - immunology
Dermatophagoides pteronyssinus - immunology
Dust
Eosinophilia - blood
Eosinophilia - immunology
Eosinophilia - physiopathology
eosinophilic airway inflammation
Female
Flow cytometry
Genotype & phenotype
Growth factors
house dust mite
Human subjects
Humans
Immune response
Immunoglobulin E - blood
Immunoglobulin G - blood
Inflammation
Leukocytes (eosinophilic)
Lipoproteins
Low Density Lipoprotein Receptor-Related Protein-1 - immunology
Low-density lipoprotein receptor–related protein 1
Lymphocytes
Lymphocytes T
Male
Metaplasia
Mice, Transgenic
Middle Aged
Pathogenesis
Peripheral blood
Phenotypes
Proteins
Receptor density
Respiratory tract
Respiratory tract diseases
Rodents
Scavenger receptors
type 2–high asthma
Title Low-density lipoprotein receptor–related protein 1 attenuates house dust mite–induced eosinophilic airway inflammation by suppressing dendritic cell–mediated adaptive immune responses
URI https://www.clinicalkey.com/#!/content/1-s2.0-S0091674917329238
https://dx.doi.org/10.1016/j.jaci.2017.10.044
https://www.ncbi.nlm.nih.gov/pubmed/29274414
https://www.proquest.com/docview/2116010102
https://www.proquest.com/docview/1979963835
Volume 142
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