TRPV1 Channels Regulate Cortical Excitability in Humans

• Published in: The Journal of neuroscience Vol. 32; no. 3; pp. 873 - 879
• Main Authors: Mori, Francesco, Ribolsi, Michele, Kusayanagi, Hajime, Monteleone, Fabrizia, Mantovani, Vilma, Buttari, Fabio, Marasco, Elena, Bernardi, Giorgio, Maccarrone, Mauro, Centonze, Diego
• Format: Journal Article
• Language: English
• Published: United States Society for Neuroscience 18.01.2012
• Subjects: Adult; Analysis of Variance; Biophysics; Evoked Potentials, Motor - genetics; Female; Gene Frequency; Genotype; Humans; Male; Middle Aged; Motor Cortex - physiology; Neuronal Plasticity - genetics; Polymorphism, Single Nucleotide - genetics; Time Factors; Transcranial Magnetic Stimulation - methods; TRPV Cation Channels - genetics

Studies in rodents show that transient receptor potential vanilloid 1 (TRPV1) channels regulate glutamate release at central and peripheral synapses. In humans, a number of nonsynonymous single-nucleotide polymorphisms (SNPs) have been described in the TRPV1 gene, and some of them significantly alte...