Paternal morphine exposure induces bidirectional effects on cocaine versus opioid self-administration

• Published in: Neuropharmacology Vol. 162; p. 107852
• Main Authors: Vassoler, Fair M., Toorie, Anika M., Teceno, Delaney N., Walia, Pankhuri, Moore, Deion J., Patton, Trevor D., Byrnes, Elizabeth M.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.01.2020
• Subjects: Acetylation; Analgesics, Opioid - administration & dosage; Analgesics, Opioid - pharmacology; Animals; Behavior, Animal; Brain-Derived Neurotrophic Factor - drug effects; Brain-Derived Neurotrophic Factor - genetics; Cocaine; Cocaine - administration & dosage; Dopamine Uptake Inhibitors - administration & dosage; Epigenesis, Genetic; Female; Histone Code - drug effects; Male; Morphine; Morphine - administration & dosage; Morphine - pharmacology; Motivation; Opioid; Oxycodone; Oxycodone - administration & dosage; Paternal Exposure; Prefrontal Cortex - drug effects; Prefrontal Cortex - metabolism; Rats; Rats, Sprague-Dawley; RNA, Messenger - drug effects; RNA, Messenger - metabolism; Self Administration; Seminiferous Tubules - drug effects; Seminiferous Tubules - metabolism; Transgenerational; Opioid; Self-administration; Morphine; Cocaine; Transgenerational; Oxycodone

The United States is in the midst of an opioid epidemic and is thus experiencing unprecedented levels of opioid exposure. A growing body of evidence has demonstrated that this may have consequences on multiple generations. The current set of experiments examined the effect of male adolescent opioid...