Multidimensional study of the oral microbiome, metabolite, and immunologic environment in peanut allergy

• Published in: Journal of allergy and clinical immunology Vol. 148; no. 2; pp. 627 - 632.e3
• Main Authors: Ho, Hsi-en, Chun, Yoojin, Jeong, Stephanie, Jumreornvong, Oranicha, Sicherer, Scott H., Bunyavanich, Supinda
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.08.2021; Elsevier Limited
• Subjects: Acetic acid; Allergies; Antigens; Asthma; cytokine; Cytokines; Dermatitis; Food allergies; Food allergy; Interleukin 13; Interleukin 4; Interleukin 5; Liquid chromatography; Lymphocytes T; Mass spectroscopy; Metabolites; metabolome; microbiome; Microbiomes; Microbiota; Mucosal immunity; Neisseria; Pathogenesis; peanut allergy; Phylogenetics; Prevotella; Propionic acid; Rhinitis; rRNA 16S; short-chain fatty acids; TH2 immunity; Thymic stromal lymphopoietin; Thymus; cytokine; Food allergy; TSLP; TH2 immunity; IQR; microbiome; SCFA; peanut allergy; LC-MS/MS; FDR; short-chain fatty acids; metabolome; mucosal immunity; T(H)2 immunity

The oral mucosa is the initial interface between food antigens, microbiota, and mucosal immunity, yet, little is known about oral host-environment dynamics in food allergy. Our aim was to determine oral microbial, metabolic, and immunologic profiles associated with peanut allergy. We recruited 105 s...