Gut dysbiosis induced by a high-salt diet aggravates atherosclerosis by increasing the absorption of saturated fatty acids in ApoE-deficient mice

• Published in: Journal of Clinical Biochemistry and Nutrition Vol. 76; no. 2; pp. 210 - 220
• Main Authors: Ushigome, Emi, Yoshimura, Takashi, Yuge, Hiroki, Ogata, Takehiro, Okamura, Takuro, Hamaguchi, Masahide, Fukui, Michiaki, Hosomi, Yukako, Kimura, Tomonori, Nakanishi, Naoko, Sasano, Ryoichi
• Format: Journal Article
• Language: English
• Published: Japan SOCIETY FOR FREE RADICAL RESEARCH JAPAN 01.01.2025; Japan Science and Technology Agency; the Society for Free Radical Research Japan
• Subjects: Absorption; Aorta; ApoE-deficient mice; Apolipoprotein E; Arteriosclerosis; Atherosclerosis; Cardiovascular diseases; CD36 antigen; Diet; Digestive system; Dysbacteriosis; Fatty acids; Gastrointestinal tract; gut dysbiosis; Health risks; High fat diet; high-salt diet; Intestinal microflora; Intestine; Lipid metabolism; Lipids; Microbiomes; Microbiota; Microorganisms; Original; Salt; Salts; saturated fatty acids; Small intestine; Sodium chloride; Sucrose; atherosclerosis; ApoE-deficient mice; saturated fatty acids; high-salt diet; gut dysbiosis

Excessive salt intake has been associated with gut dysbiosis and increased cardiovascular risk. This study investigates the role of gut dysbiosis induced by a high-salt diet in the progression of atherosclerosis in ApoE-deficient mice. Sixteen-week-old male ApoE-deficient mice were fed either a high...