Sall genes regulate region-specific morphogenesis in the mouse limb by modulating Hox activities

• Published in: Development (Cambridge) Vol. 136; no. 4; pp. 585 - 594
• Main Authors: Kawakami, Yasuhiko, Uchiyama, Yukako, Rodriguez Esteban, Concepcion, Inenaga, Toshiaki, Koyano-Nakagawa, Naoko, Kawakami, Hiroko, Marti, Merce, Kmita, Marie, Monaghan-Nichols, Paula, Nishinakamura, Ryuichi, Izpisua Belmonte, Juan Carlos
• Format: Journal Article
• Language: English
• Published: England The Company of Biologists Limited 15.02.2009; Company of Biologists
• Subjects: Animals; Extremities - embryology; Gene Expression Regulation, Developmental; Hedgehog Proteins - metabolism; Homeodomain Proteins - genetics; Homeodomain Proteins - metabolism; Kruppel-Like Transcription Factors - metabolism; Mice; Morphogenesis; Mutation - genetics; Nerve Tissue Proteins - metabolism; Organ Specificity; Receptor, EphA3 - metabolism; Receptor, EphA4 - metabolism; Signal Transduction; T-Box Domain Proteins - metabolism; Transcription Factors - genetics; Transcription Factors - metabolism; Zinc Finger Protein Gli3

The genetic mechanisms that regulate the complex morphogenesis of generating cartilage elements in correct positions with precise shapes during organogenesis, fundamental issues in developmental biology, are still not well understood. By focusing on the developing mouse limb, we confirm the importan...