An in vitro investigation of species-dependent intestinal transport of selenium and the impact of this process on selenium bioavailability

• Published in: British journal of nutrition Vol. 109; no. 12; pp. 2126 - 2134
• Main Authors: Thiry, Celine, Ruttens, Ann, Pussemier, Luc, Schneider, Yves-Jacques
• Format: Journal Article
• Language: English
• Published: Cambridge, UK Cambridge University Press 28.06.2013
• Subjects: absorption; Analysis of Variance; Bioavailability; Biological and medical sciences; Biological Availability; Biological Transport; Caco-2 Cells; Cell culture; Feeding. Feeding behavior; foods; Fundamental and applied biological sciences. Psychology; human cell lines; Humans; Intestinal Absorption - physiology; Intestines - metabolism; Metabolism and Metabolic Studies; methionine; methylselenocysteine; Nutrition; selenates; selenites; Selenium; Selenium - metabolism; Selenium - pharmacokinetics; selenomethionine; Speciation; Spectrophotometry, Atomic; Tight Junctions - metabolism; Toxicity; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Selenium species; Transport mechanisms; Selenium; Intestinal absorption; Nutrition; Digestive system; Biological transport; Gut; Bioavailability; In vitro; Mechanism; Micronutrient; Absorption

A range of Se species has been shown to occur in a variety of different foodstuffs. Depending on its speciation, Se is more or less bioavailable to human subjects. In the present study, the role of speciation as a determinant of Se bioavailability was addressed with an investigation of species-speci...