Cerebrovascular atherosclerosis correlates with Alzheimer pathology in neurodegenerative dementias

• Published in: Brain (London, England : 1878) Vol. 135; no. 12; pp. 3749 - 3756
• Main Authors: Yarchoan, Mark, Xie, Sharon X., Kling, Mitchel A., Toledo, Jon B., Wolk, David A., Lee, Edward B., Van Deerlin, Vivianna, Lee, Virginia M.-Y., Trojanowski, John Q., Arnold, Steven E.
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.12.2012
• Subjects: Aged; Aged, 80 and over; Aging - pathology; alpha-Synuclein - metabolism; Alzheimer Disease - pathology; Analysis of Variance; Biological and medical sciences; Cerebral Amyloid Angiopathy; Chi-Square Distribution; Circle of Willis - pathology; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Dementia - complications; Dementia - pathology; DNA-Binding Proteins - metabolism; Female; Humans; Intracranial Arteriosclerosis - pathology; Male; Medical sciences; Middle Aged; Neurodegenerative Diseases - complications; Neurodegenerative Diseases - pathology; Neurofibrillary Tangles - pathology; Neurology; Original; Retrospective Studies; Risk Factors; atherosclerosis; synuclein; TDP-43; neurofibrillary tangles; neuritic plaques; Nervous system diseases; Alzheimer disease; Cardiovascular disease; Neurofibrillary tangle; Cerebral disorder; Vascular disease; Anatomic pathology; Central nervous system disease; Atherosclerosis; Degenerative disease

A growing body of evidence demonstrates an association between vascular risk factors and Alzheimer’s disease. This study investigated the frequency and severity of atherosclerotic plaques in the circle of Willis in Alzheimer’s disease and multiple other neurodegenerative diseases. Semi-quantitative...