Influence of fluoroquinolone consumption in inpatients and outpatients on ciprofloxacin-resistant Escherichia coli in a university hospital

• Published in: Journal of antimicrobial chemotherapy Vol. 65; no. 12; pp. 2650 - 2657
• Main Authors: Gallini, A., Degris, E., Desplas, M., Bourrel, R., Archambaud, M., Montastruc, J.-L., Lapeyre-Mestre, M., Sommet, A.
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.12.2010; Oxford Publishing Limited (England)
• Subjects: Anti-Infective Agents - pharmacology; Anti-Infective Agents - therapeutic use; Antibiotics; Antibiotics. Antiinfectious agents. Antiparasitic agents; antimicrobials; Biological and medical sciences; Chemotherapy; Ciprofloxacin - pharmacology; Drug resistance; Drug Resistance, Bacterial; drug use; Drug Utilization - statistics & numerical data; dynamic regression; E coli; Escherichia coli; Escherichia coli - drug effects; Escherichia coli - isolation & purification; Escherichia coli Infections - drug therapy; Escherichia coli Infections - microbiology; Fluoroquinolones - pharmacology; Fluoroquinolones - therapeutic use; France; Hospitals, University; Humans; Inpatients; linear transfer function; Medical sciences; Microbial Sensitivity Tests; Outpatients; Pharmacology. Drug treatments; resistance; time-series analysis; France; Toulouse France; Consumption; Human; Drug; Escherichia coli; dynamic regression; Time series; Regression; antimicrobials; Antimicrobial agent; Resistance; Fluoroquinolone derivatives; University; Dynamics; linear transfer function; Bacteria; drug use; Ambulatory; Hospital; Antibacterial agent; Time analysis; Enterobacteriaceae; time-series analysis

Background The increase in fluoroquinolone-resistant Escherichia coli has raised the issue of treatment failure in common infections. Few studies have investigated the possible relationship between outpatient fluoroquinolone consumption and resistance in hospital. Objective To investigate the relati...