Oxime Therapy for Brain AChE Reactivation and Neuroprotection after Organophosphate Poisoning

• Published in: Pharmaceutics Vol. 14; no. 9; p. 1950
• Main Authors: Kuznetsova, Darya A., Gaynanova, Gulnara A., Vasilieva, Elmira A., Pavlov, Rais V., Zueva, Irina V., Babaev, Vasily M., Kuznetsov, Denis M., Voloshina, Alexandra D., Petrov, Konstantin A., Zakharova, Lucia Y., Sinyashin, Oleg G.
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 01.09.2022; MDPI
• Subjects: acetylcholinesterase reactivation; blood-brain barrier; Brain; cationic liposome; Composition; Dosage and administration; Hemodialysis; Hydration; imidazolium surfactant; Lipids; Medical research; Microscopy; Nervous system; Neuroprotective agents; Organophosphorus compounds; Pesticides; Poisoning; Prevention; Risk factors; Surface active agents; Surfactants; targeted drug delivery; Viscosity; Germany; St Louis Missouri; United States > US

One of the main problems in the treatment of poisoning with organophosphorus (OPs) inhibitors of acetylcholinesterase (AChE) is low ability of existing reactivators of AChE that are used as antidotes to cross the blood-brain barrier (BBB). In this work, modified cationic liposomes were developed tha...