Limitations in the use of rifampicin-gelatin grafts against virulent organisms

• Published in: Journal of vascular surgery Vol. 35; no. 4; pp. 779 - 785
• Main Authors: Koshiko, Susumu, Sasajima, Tadahiro, Muraki, Senichi, Azuma, Nobuyoshi, Yamazaki, Kohsuke, Chiba, Kaoru, Tachibana, Mineji, Inaba, Masashi
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.04.2002
• Subjects: Animals; Antibiotics, Antitubercular - administration & dosage; Antibiotics, Antitubercular - pharmacology; Blood Vessel Prosthesis - adverse effects; Blood Vessel Prosthesis Implantation; Dogs; Escherichia coli - drug effects; Escherichia coli Infections - prevention & control; Gelatin; Methicillin Resistance; Microbial Sensitivity Tests; Prosthesis-Related Infections - drug therapy; Rifampin - administration & dosage; Rifampin - pharmacology; Staphylococcal Infections - prevention & control; Staphylococcus aureus - drug effects; Staphylococcus epidermidis - drug effects; Time Factors

Objective: Efficacy and duration of antibacterial activity of rifampicin-gelatin grafts against virulent organisms were evaluated in an animal model. Materials and Methods: Rifampicin-gelatin grafts were prepared with impregnation of Gelseal (Vascutek Ltd, Scotland) graft in 1 mg/mL rifampicin solut...