SARS-CoV-2 infection elucidates features of pregnancy-specific immunity

• Published in: Cell reports (Cambridge) Vol. 43; no. 11; p. 114933
• Main Authors: Oh, Dong Sun, Kim, Eunha, Normand, Rachelly, Lu, Guangqing, Shook, Lydia L., Lyall, Amanda, Jasset, Olyvia, Demidkin, Stepan, Gilbert, Emily, Kim, Joon, Akinwunmi, Babatunde, Tantivit, Jessica, Tirard, Alice, Arnold, Benjamin Y., Slowikowski, Kamil, Goldberg, Marcia B., Filbin, Michael R., Hacohen, Nir, Nguyen, Long H., Chan, Andrew T., Yu, Xu G., Li, Jonathan Z., Yonker, Lael, Fasano, Alessio, Perlis, Roy H., Pasternak, Ofer, Gray, Kathryn J., Choi, Gloria B., Drew, David A., Sen, Pritha, Villani, Alexandra-Chloé, Edlow, Andrea G., Huh, Jun R.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 26.11.2024; Elsevier
• Subjects: Adult; CD4-Positive T-Lymphocytes - immunology; CD8-Positive T-Lymphocytes - immunology; COVID-19; COVID-19 - blood; COVID-19 - immunology; COVID-19 - virology; CP: Immunology; cytokines; Cytokines - blood; Cytokines - metabolism; Female; Humans; immune cells; immune responses; Leukocytes, Mononuclear - immunology; maternal immune activation; Pregnancy; Pregnancy Complications, Infectious - blood; Pregnancy Complications, Infectious - immunology; Pregnancy Complications, Infectious - virology; SARS-CoV-2; SARS-CoV-2 - immunology; single-cell RNA-seq; T cells; COVID-19; CP: Immunology; SARS-CoV-2; pregnancy; maternal immune activation; single-cell RNA-seq; immune cells; cytokines; T cells; immune responses

Pregnancy is a risk factor for increased severity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and other respiratory infections, but the mechanisms underlying this risk are poorly understood. To gain insight into the role of pregnancy in modulating immune responses at baseline and...