Distinguishing between translational science and translational research in CTSA pilot studies: A collaborative project across 12 CTSA hubs
The institutions (i.e., hubs) making up the National Institutes of Health (NIH)-funded network of Clinical and Translational Science Awards (CTSAs) share a mission to turn observations into interventions to improve public health. Recently, the focus of the CTSAs has turned increasingly from translat...
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Published in | Journal of clinical and translational science Vol. 8; no. 1; p. e4 |
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Main Authors | , , , , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
England
Cambridge University Press
2024
|
Subjects | |
Online Access | Get full text |
ISSN | 2059-8661 2059-8661 |
DOI | 10.1017/cts.2023.700 |
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Abstract | The institutions (i.e., hubs) making up the National Institutes of Health (NIH)-funded network of Clinical and Translational Science Awards (CTSAs) share a mission to turn observations into interventions to improve public health. Recently, the focus of the CTSAs has turned increasingly from translational research (TR) to translational science (TS). The current NIH Funding Opportunity Announcement (PAR-21-293) for CTSAs stipulates that pilot studies funded through the CTSAs must be "focused on understanding a scientific or operational principle underlying a step of the translational process with the goal of developing generalizable solutions to accelerate translational research." This new directive places Pilot Program administrators in the position of arbiters with the task of distinguishing between TR and TS projects. The purpose of this study was to explore the utility of a set of TS principles set forth by NCATS for distinguishing between TR and TS.
Twelve CTSA hubs collaborated to generate a list of Translational Science Principles questions. Twenty-nine Pilot Program administrators used these questions to evaluate 26 CTSA-funded pilot studies.
Factor analysis yielded three factors: Generalizability/Efficiency, Disruptive Innovation, and Team Science. The Generalizability/Efficiency factor explained the largest amount of variance in the questions and was significantly able to distinguish between projects that were verified as TS or TR (
= 6.92,
< .001) by an expert panel.
The seven questions in this factor may be useful for informing deliberations regarding whether a study addresses a question that aligns with NCATS' vision of TS. |
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AbstractList | The institutions (i.e., hubs) making up the National Institutes of Health (NIH)-funded network of Clinical and Translational Science Awards (CTSAs) share a mission to turn observations into interventions to improve public health. Recently, the focus of the CTSAs has turned increasingly from translational research (TR) to translational science (TS). The current NIH Funding Opportunity Announcement (PAR-21-293) for CTSAs stipulates that pilot studies funded through the CTSAs must be "focused on understanding a scientific or operational principle underlying a step of the translational process with the goal of developing generalizable solutions to accelerate translational research." This new directive places Pilot Program administrators in the position of arbiters with the task of distinguishing between TR and TS projects. The purpose of this study was to explore the utility of a set of TS principles set forth by NCATS for distinguishing between TR and TS.IntroductionThe institutions (i.e., hubs) making up the National Institutes of Health (NIH)-funded network of Clinical and Translational Science Awards (CTSAs) share a mission to turn observations into interventions to improve public health. Recently, the focus of the CTSAs has turned increasingly from translational research (TR) to translational science (TS). The current NIH Funding Opportunity Announcement (PAR-21-293) for CTSAs stipulates that pilot studies funded through the CTSAs must be "focused on understanding a scientific or operational principle underlying a step of the translational process with the goal of developing generalizable solutions to accelerate translational research." This new directive places Pilot Program administrators in the position of arbiters with the task of distinguishing between TR and TS projects. The purpose of this study was to explore the utility of a set of TS principles set forth by NCATS for distinguishing between TR and TS.Twelve CTSA hubs collaborated to generate a list of Translational Science Principles questions. Twenty-nine Pilot Program administrators used these questions to evaluate 26 CTSA-funded pilot studies.MethodsTwelve CTSA hubs collaborated to generate a list of Translational Science Principles questions. Twenty-nine Pilot Program administrators used these questions to evaluate 26 CTSA-funded pilot studies.Factor analysis yielded three factors: Generalizability/Efficiency, Disruptive Innovation, and Team Science. The Generalizability/Efficiency factor explained the largest amount of variance in the questions and was significantly able to distinguish between projects that were verified as TS or TR (t = 6.92, p < .001) by an expert panel.ResultsFactor analysis yielded three factors: Generalizability/Efficiency, Disruptive Innovation, and Team Science. The Generalizability/Efficiency factor explained the largest amount of variance in the questions and was significantly able to distinguish between projects that were verified as TS or TR (t = 6.92, p < .001) by an expert panel.The seven questions in this factor may be useful for informing deliberations regarding whether a study addresses a question that aligns with NCATS' vision of TS.ConclusionsThe seven questions in this factor may be useful for informing deliberations regarding whether a study addresses a question that aligns with NCATS' vision of TS. Introduction:The institutions (i.e., hubs) making up the National Institutes of Health (NIH)-funded network of Clinical and Translational Science Awards (CTSAs) share a mission to turn observations into interventions to improve public health. Recently, the focus of the CTSAs has turned increasingly from translational research (TR) to translational science (TS). The current NIH Funding Opportunity Announcement (PAR-21-293) for CTSAs stipulates that pilot studies funded through the CTSAs must be “focused on understanding a scientific or operational principle underlying a step of the translational process with the goal of developing generalizable solutions to accelerate translational research.” This new directive places Pilot Program administrators in the position of arbiters with the task of distinguishing between TR and TS projects. The purpose of this study was to explore the utility of a set of TS principles set forth by NCATS for distinguishing between TR and TS.Methods:Twelve CTSA hubs collaborated to generate a list of Translational Science Principles questions. Twenty-nine Pilot Program administrators used these questions to evaluate 26 CTSA-funded pilot studies.Results:Factor analysis yielded three factors: Generalizability/Efficiency, Disruptive Innovation, and Team Science. The Generalizability/Efficiency factor explained the largest amount of variance in the questions and was significantly able to distinguish between projects that were verified as TS or TR (t = 6.92, p < .001) by an expert panel.Conclusions:The seven questions in this factor may be useful for informing deliberations regarding whether a study addresses a question that aligns with NCATS’ vision of TS. The institutions (i.e., hubs) making up the National Institutes of Health (NIH)-funded network of Clinical and Translational Science Awards (CTSAs) share a mission to turn observations into interventions to improve public health. Recently, the focus of the CTSAs has turned increasingly from translational research (TR) to translational science (TS). The current NIH Funding Opportunity Announcement (PAR-21-293) for CTSAs stipulates that pilot studies funded through the CTSAs must be "focused on understanding a scientific or operational principle underlying a step of the translational process with the goal of developing generalizable solutions to accelerate translational research." This new directive places Pilot Program administrators in the position of arbiters with the task of distinguishing between TR and TS projects. The purpose of this study was to explore the utility of a set of TS principles set forth by NCATS for distinguishing between TR and TS. Twelve CTSA hubs collaborated to generate a list of Translational Science Principles questions. Twenty-nine Pilot Program administrators used these questions to evaluate 26 CTSA-funded pilot studies. Factor analysis yielded three factors: Generalizability/Efficiency, Disruptive Innovation, and Team Science. The Generalizability/Efficiency factor explained the largest amount of variance in the questions and was significantly able to distinguish between projects that were verified as TS or TR ( = 6.92, < .001) by an expert panel. The seven questions in this factor may be useful for informing deliberations regarding whether a study addresses a question that aligns with NCATS' vision of TS. Abstract Introduction: The institutions (i.e., hubs) making up the National Institutes of Health (NIH)-funded network of Clinical and Translational Science Awards (CTSAs) share a mission to turn observations into interventions to improve public health. Recently, the focus of the CTSAs has turned increasingly from translational research (TR) to translational science (TS). The current NIH Funding Opportunity Announcement (PAR-21-293) for CTSAs stipulates that pilot studies funded through the CTSAs must be “focused on understanding a scientific or operational principle underlying a step of the translational process with the goal of developing generalizable solutions to accelerate translational research.” This new directive places Pilot Program administrators in the position of arbiters with the task of distinguishing between TR and TS projects. The purpose of this study was to explore the utility of a set of TS principles set forth by NCATS for distinguishing between TR and TS. Methods: Twelve CTSA hubs collaborated to generate a list of Translational Science Principles questions. Twenty-nine Pilot Program administrators used these questions to evaluate 26 CTSA-funded pilot studies. Results: Factor analysis yielded three factors: Generalizability/Efficiency, Disruptive Innovation, and Team Science. The Generalizability/Efficiency factor explained the largest amount of variance in the questions and was significantly able to distinguish between projects that were verified as TS or TR (t = 6.92, p < .001) by an expert panel. Conclusions: The seven questions in this factor may be useful for informing deliberations regarding whether a study addresses a question that aligns with NCATS’ vision of TS. |
ArticleNumber | e4 |
Author | Ericson, Marissa Boerger, Lindsie Denne, Scott McCoy, Renee Woodworth, Amanda Dillon, Pam Duguid, Paul Rodriguez, Vonda Zaleski, Jeffrey Schneider, Margaret Li, Jennifer S. Prokofieva, Nadia Hunt, Joe Xiang, Henry Ghanem, Eman Sparks, Crystal |
AuthorAffiliation | 5 The Translational Research Institute, University of Arkansas Medical Sciences , Little Rock , AR , USA 7 Clinical & Translational Science Institute of Southeast Wisconsin, Medical College of Wisconsin , Milwaukee , WI , USA 2 The Institute of Translational Health Sciences, University of Washington , Seattle , WA , USA 3 The Indiana Clinical and Translational Sciences Institute, Indiana University , Indianapolis , IN , USA 6 Duke Clinical & Translational Science Institute, Duke University , Durham , NC , USA 1 The Institute for Clinical and Translational Science, University of California , Irvine , CA , USA 4 The Wright Center for Clinical and Translational Research, Virginia Commonwealth University , Richmond , VA , USA 8 Tufts Clinical and Translational Science Institute, Tufts University , Boston , MA , USA 9 Center for Clinical and Translational Science, The Ohio State University , Columbus , OH , USA |
AuthorAffiliation_xml | – name: 7 Clinical & Translational Science Institute of Southeast Wisconsin, Medical College of Wisconsin , Milwaukee , WI , USA – name: 1 The Institute for Clinical and Translational Science, University of California , Irvine , CA , USA – name: 3 The Indiana Clinical and Translational Sciences Institute, Indiana University , Indianapolis , IN , USA – name: 2 The Institute of Translational Health Sciences, University of Washington , Seattle , WA , USA – name: 6 Duke Clinical & Translational Science Institute, Duke University , Durham , NC , USA – name: 9 Center for Clinical and Translational Science, The Ohio State University , Columbus , OH , USA – name: 4 The Wright Center for Clinical and Translational Research, Virginia Commonwealth University , Richmond , VA , USA – name: 5 The Translational Research Institute, University of Arkansas Medical Sciences , Little Rock , AR , USA – name: 8 Tufts Clinical and Translational Science Institute, Tufts University , Boston , MA , USA |
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Cites_doi | 10.4159/9780674974135 10.1093/jamia/ocy177 10.2144/000112749 10.1017/cts.2019.411 10.2183/pjab.95.037 10.1016/j.jbi.2008.08.010 10.1007/s40656-019-0293-7 10.1097/NUR.0000000000000728 10.1038/nrd.2018.27 10.1037/amp0000319 10.1111/cts.13055 10.1017/cts.2020.31 10.1038/s41684-021-00890-0 10.1038/d41573-021-00008-8 10.1177/0095798418771807 10.1016/j.jogn.2021.09.007 10.1001/jamapediatrics.2022.4823 10.1177/001316446002000116 10.1207/s15327906mbr0102_10 10.1016/j.jbi.2019.103208 10.1258/jrsm.2011.110180 10.1111/cts.13390 10.1007/s11192-020-03668-2 |
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Snippet | The institutions (i.e., hubs) making up the National Institutes of Health (NIH)-funded network of Clinical and Translational Science Awards (CTSAs) share a... Introduction:The institutions (i.e., hubs) making up the National Institutes of Health (NIH)-funded network of Clinical and Translational Science Awards... Abstract Introduction: The institutions (i.e., hubs) making up the National Institutes of Health (NIH)-funded network of Clinical and Translational Science... |
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SubjectTerms | Clinical medicine Collaboration efficiency Electronic health records Factor analysis generalizability Human subjects Implementation, Policy and Community Engagement Innovations Pilot projects Principles Public health Research funding Science Translation translational research Translational science |
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Title | Distinguishing between translational science and translational research in CTSA pilot studies: A collaborative project across 12 CTSA hubs |
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