Endothelins in inflammatory neurological diseases
Endothelins were discovered more than thirty years ago as potent vasoactive compounds. Beyond their well-documented cardiovascular properties, however, the contributions of the endothelin pathway have been demonstrated in several neuroinflammatory processes and the peptides have been reported as cli...
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| Published in | Pharmacology & therapeutics (Oxford) Vol. 194; pp. 145 - 160 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
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England
Elsevier Inc
01.02.2019
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| Subjects | |
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| Abstract | Endothelins were discovered more than thirty years ago as potent vasoactive compounds. Beyond their well-documented cardiovascular properties, however, the contributions of the endothelin pathway have been demonstrated in several neuroinflammatory processes and the peptides have been reported as clinically relevant biomarkers in neurodegenerative diseases. Several studies report that endothelin-1 significantly contributes to the progression of neuroinflammatory processes, particularly during infections in the central nervous system (CNS), and is associated with a loss of endothelial integrity at the blood brain barrier level. Because of the paucity of clinical trials with endothelin-1 antagonists in several infectious and non-infectious neuroinflammatory diseases, it remains an open question whether the 21 amino acid peptide is a mediator/modulator rather than a biomarker of the progression of neurodegeneration. This review focuses on the potential roles of endothelins in the pathology of neuroinflammatory processes, including infectious diseases of viral, bacterial or parasitic origin in which the synthesis of endothelins or its pharmacology have been investigated from the cell to the bedside in several cases, as well as in non-infectious inflammatory processes such as neurodegenerative disorders like Alzheimers Disease or central nervous system vasculitis. |
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| AbstractList | Endothelins were discovered more than thirty years ago as potent vasoactive compounds. Beyond their well-documented cardiovascular properties, however, the contributions of the endothelin pathway have been demonstrated in several neuroinflammatory processes and the peptides have been reported as clinically relevant biomarkers in neurodegenerative diseases. Several studies report that endothelin-1 significantly contributes to the progression of neuroinflammatory processes, particularly during infections in the central nervous system (CNS), and is associated with a loss of endothelial integrity at the blood brain barrier level. Because of the paucity of clinical trials with endothelin-1 antagonists in several infectious and non-infectious neuroinflammatory diseases, it remains an open question whether the 21 amino acid peptide is a mediator/modulator rather than a biomarker of the progression of neurodegeneration. This review focuses on the potential roles of endothelins in the pathology of neuroinflammatory processes, including infectious diseases of viral, bacterial or parasitic origin in which the synthesis of endothelins or its pharmacology have been investigated from the cell to the bedside in several cases, as well as in non-infectious inflammatory processes such as neurodegenerative disorders like Alzheimers Disease or central nervous system vasculitis. Endothelins were discovered more than thirty years ago as potent vasoactive compounds. Beyond their well-documented cardiovascular properties, however, the contributions of the endothelin pathway have been demonstrated in several neuroinflammatory processes and the peptides have been reported as clinically relevant biomarkers in neurodegenerative diseases. Several studies report that endothelin-1 significantly contributes to the progression of neuroinflammatory processes, particularly during infections in the central nervous system (CNS), and is associated with a loss of endothelial integrity at the blood brain barrier level. Because of the paucity of clinical trials with endothelin-1 antagonists in several infectious and non-infectious neuroinflammatory diseases, it remains an open question whether the 21 amino acid peptide is a mediator/modulator rather than a biomarker of the progression of neurodegeneration. This review focuses on the potential roles of endothelins in the pathology of neuroinflammatory processes, including infectious diseases of viral, bacterial or parasitic origin in which the synthesis of endothelins or its pharmacology have been investigated from the cell to the bedside in several cases, as well as in non-infectious inflammatory processes such as neurodegenerative disorders like Alzheimers Disease or central nervous system vasculitis.Endothelins were discovered more than thirty years ago as potent vasoactive compounds. Beyond their well-documented cardiovascular properties, however, the contributions of the endothelin pathway have been demonstrated in several neuroinflammatory processes and the peptides have been reported as clinically relevant biomarkers in neurodegenerative diseases. Several studies report that endothelin-1 significantly contributes to the progression of neuroinflammatory processes, particularly during infections in the central nervous system (CNS), and is associated with a loss of endothelial integrity at the blood brain barrier level. Because of the paucity of clinical trials with endothelin-1 antagonists in several infectious and non-infectious neuroinflammatory diseases, it remains an open question whether the 21 amino acid peptide is a mediator/modulator rather than a biomarker of the progression of neurodegeneration. This review focuses on the potential roles of endothelins in the pathology of neuroinflammatory processes, including infectious diseases of viral, bacterial or parasitic origin in which the synthesis of endothelins or its pharmacology have been investigated from the cell to the bedside in several cases, as well as in non-infectious inflammatory processes such as neurodegenerative disorders like Alzheimers Disease or central nervous system vasculitis. Endothelins were discovered more than thirty years ago as potent vasoactive compounds. Beyond their well-documented vasomodulatory properties, however, the contributions of the endothelin pathway have been demonstrated in several neuroinflammatory processes and the peptides have been reported as a clinically relevant biomarkers in neurodegenerative diseases. Several published works suggest that endothelin-1 greatly contributes to the progression of neuroinflammatory processes, particularly during infections in the central nervous system (CNS), and is associated with a loss of endothelial integrity at the blood brain barrier level. Because of the paucity of clinical trials with endothelin-1 antagonists in several infectious and non-infectious neuroinflammatory diseases, it remains an open question whether the 21 amino acid peptide is a mediator rather than a biomarker of the progression of neurodegeneration. The present review focuses on the potential roles of endothelins in the pathology of neuroinflammatory processes, including infectious diseases of viral, bacterial or parasitic origin in which the synthesis of endothelins or its pharmacology have been investigated from the cell to the bedside in several cases, and non-infectious inflammatory processes such as neurodegenerative disorders like Alzheimers Disease or central nervous system vasculitis. |
| Author | Desbiens, Louisane D'Orléans-Juste, Pedro Desruisseaux, Mahalia S. Tanowitz, Herbert B. Akide Ndunge, Oscar B. |
| AuthorAffiliation | 2 Department of Medicine. Yale University School of Medicine, New Haven, CT, USA 1 Department of Pharmacology. Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, Quebec, CA 3 Departments of Medicine and Pathology, Albert Einstein College of Medicine, Bronx, NY, USA |
| AuthorAffiliation_xml | – name: 2 Department of Medicine. Yale University School of Medicine, New Haven, CT, USA – name: 3 Departments of Medicine and Pathology, Albert Einstein College of Medicine, Bronx, NY, USA – name: 1 Department of Pharmacology. Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, Quebec, CA |
| Author_xml | – sequence: 1 givenname: Pedro surname: D'Orléans-Juste fullname: D'Orléans-Juste, Pedro organization: Department of Pharmacology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, Quebec, CA, USA – sequence: 2 givenname: Oscar B. surname: Akide Ndunge fullname: Akide Ndunge, Oscar B. organization: Department of Medicine, Yale University School of Medicine, New Haven, CT, USA – sequence: 3 givenname: Louisane surname: Desbiens fullname: Desbiens, Louisane organization: Department of Pharmacology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, Quebec, CA, USA – sequence: 4 givenname: Herbert B. surname: Tanowitz fullname: Tanowitz, Herbert B. organization: Departments of Medicine and Pathology, Albert Einstein College of Medicine, Bronx, NY, USA – sequence: 5 givenname: Mahalia S. surname: Desruisseaux fullname: Desruisseaux, Mahalia S. email: mahalia.desruisseaux@yale.edu organization: Department of Medicine, Yale University School of Medicine, New Haven, CT, USA |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30291906$$D View this record in MEDLINE/PubMed |
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| Keywords | APP CXCL NO BBB CBF Central nervous system Blood-brain barrier (BBB) CNS ICAM-1 HSV-2 SLE HAND Aβ CNSV HSV-1 KSHV DENV HHV AD Cytokines GCA Endothelin subtype A receptor (ETA) ECE MS EAE KS CM Cerebral blood flow (CBF) CCL CMV Endothelin-1 (ET-1) Chymase ET ETB VCAM-1 ET-1 ETA HIV Endothelin subtype B receptor (ETB) NEP Mast cells VSMC Endothelin subtype B receptor (ET(B)) Endothelin subtype A receptor (ET(A)) |
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| Snippet | Endothelins were discovered more than thirty years ago as potent vasoactive compounds. Beyond their well-documented cardiovascular properties, however, the... Endothelins were discovered more than thirty years ago as potent vasoactive compounds. Beyond their well-documented vasomodulatory properties, however, the... |
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| SubjectTerms | Animals Blood-brain barrier (BBB) Central nervous system Cerebral blood flow (CBF) Chymase Cytokines Endothelin subtype A receptor (ETA) Endothelin subtype B receptor (ETB) Endothelin-1 (ET-1) Endothelins - metabolism Humans Inflammation - metabolism Mast cells Nervous System Diseases - metabolism |
| Title | Endothelins in inflammatory neurological diseases |
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