Pharmacokinetics and dosage adjustment in patients with renal dysfunction

• Published in: European journal of clinical pharmacology Vol. 65; no. 8; pp. 757 - 773
• Main Authors: Verbeeck, Roger K, Musuamba, Flora T
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Berlin/Heidelberg : Springer-Verlag 01.08.2009; Springer-Verlag; Springer; Springer Nature B.V
• Subjects: Biological and medical sciences; Biomarkers - blood; Biomedical and Life Sciences; Biomedicine; Creatinine - blood; Dosage adjustment; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug therapy; Glomerular Filtration Rate; Hepatorenal Syndrome - metabolism; Humans; Kidney - metabolism; Kidney diseases; Kidney Failure, Chronic - blood; Kidney Failure, Chronic - metabolism; Kidney Function Tests; Mathematical Computing; Medical sciences; Metabolic Clearance Rate; Non-renal drug clearance; Pharmacokinetic/pharmacodynamic processes; Pharmacokinetics; Pharmacology; Pharmacology. Drug treatments; Pharmacology/Toxicology; Renal Dialysis; Renal drug clearance; Renal dysfunction; Review Article; Severity of Illness Index; Side effects; Renal drug clearance; Dosage adjustment; Non-renal drug clearance; Pharmacokinetic/pharmacodynamic processes; Renal dysfunction; Human; Drug; Pharmacodynamics; Clearance; Biological activity; Kidney; Urinary system; Dysfunction; Pharmacokinetics

Introduction Chronic kidney disease is a common, progressive illness that is becoming a global public health problem. In patients with kidney dysfunction, the renal excretion of parent drug and/or its metabolites will be impaired, leading to their excessive accumulation in the body. In addition, the...