Registered and Antiregistered Phase Separation of Mixed Amphiphilic Bilayers

• Published in: Biophysical journal Vol. 108; no. 8; pp. 1963 - 1976
• Main Authors: Williamson, John J., Olmsted, Peter D.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 21.04.2015; Biophysical Society; The Biophysical Society
• Subjects: Hydrophobic and Hydrophilic Interactions; Kinetics; Lipid Bilayers - chemistry; Lipids; Membranes; Parameter estimation; Phase Transition; Phase transitions; Phospholipids - chemistry; Surface-Active Agents - chemistry

We derive a mean-field free energy for the phase behavior of coupled bilayer leaflets, which is implicated in cellular processes and important to the design of artificial membranes. Our model accounts for amphiphile-level structural features, particularly hydrophobic mismatch, which promotes antireg...