Predictive ability, validity, and responsiveness of the multi-biomarker disease activity score in patients with rheumatoid arthritis initiating methotrexate

• Published in: Seminars in arthritis and rheumatism Vol. 50; no. 5; pp. 1058 - 1063
• Main Authors: Luedders, Brent A., Johnson, Tate M., Sayles, Harlan, Thiele, Geoffrey M., Mikuls, Ted R., O'Dell, James R., England, Bryant R.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.10.2020
• Subjects: Antirheumatic Agents - therapeutic use; Arthritis, Rheumatoid - diagnosis; Arthritis, Rheumatoid - drug therapy; Biomarker; Biomarkers; Disease activity; Disease Progression; Humans; MBDA score; Methotrexate - therapeutic use; Psychometrics; Responsiveness; Rheumatoid arthritis; Severity of Illness Index; Treatment Outcome; Responsiveness; Psychometrics; Biomarker; MBDA score; Disease activity; Rheumatoid arthritis

•Few studies have evaluated whether the multibiomarker disease activity (MBDA) score predicts methotrexate treatment response in patients with RA as well as the validity and responsiveness of the MBDA score during methotrexate treatment.•The MBDA score demonstrated weak-to-moderate correlations with...