Platelet inhibition by low-dose aspirin is not influenced by body mass or weight

• Published in: Platelets (Edinburgh) Vol. 33; no. 8; pp. 1208 - 1213
• Main Authors: Heffron, Sean P., Windheim, Joseph, Barrett, Tessa J., Voora, Deepak, Berger, Jeffrey S.
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 17.11.2022; Taylor & Francis Group
• Subjects: Adenosine Diphosphate - pharmacology; Adult; Arachidonic Acid - pharmacology; Aspirin; Aspirin - pharmacology; Aspirin - therapeutic use; Blood Platelets; Body Weight; Collagen - pharmacology; cyclooxygenase 1; Humans; obesity; Platelet Aggregation; Platelet Aggregation Inhibitors - pharmacology; Platelet Aggregation Inhibitors - therapeutic use; Platelet Function Tests; body weight; Aspirin; cyclooxygenase 1; obesity; platelet aggregation

Aspirin's clinical efficacy may be influenced by body weight and mass. Although inadequate platelet inhibition by aspirin is suggested as responsible, evidence for this in non-diabetic patients is sparse. We investigated the influence of body weight and mass on aspirin's inhibition of plat...