A Call to Arms: Quest for a Cryptococcal Vaccine

• Published in: Trends in microbiology (Regular ed.) Vol. 26; no. 5; pp. 436 - 446
• Main Authors: Caballero Van Dyke, Marley C., Wormley, Floyd L.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.05.2018; Elsevier Science Ltd
• Subjects: Acquired immune deficiency syndrome; AIDS; Animals; Antigens, Fungal - immunology; cryptococcal vaccine; Cryptococcosis; Cryptococcosis - immunology; Cryptococcosis - prevention & control; Cryptococcus; Cryptococcus gattii; Cryptococcus gattii - immunology; Cryptococcus gattii - pathogenicity; Cryptococcus neoformans; Cryptococcus neoformans - immunology; Cryptococcus neoformans - pathogenicity; Disease Models, Animal; Disease prevention; Fungal infections; Fungal Proteins - immunology; Fungal Vaccines; Fungi; Glycolipids - immunology; Humans; Investment; Literature reviews; Morbidity; R&D; Recombinant Proteins - immunology; Research & development; Vaccination; Vaccines; Vaccines, Attenuated - immunology; Vaccines, Inactivated - immunology; Vaccines, Synthetic - immunology; Cryptococcus gattii; Cryptococcus; cryptococcal vaccine; Cryptococcus neoformans; cryptococcosis

Cryptococcosis remains a significant cause of morbidity and mortality world-wide, particularly among AIDS patients. Yet, to date, there are no licensed vaccines clinically available to treat or prevent cryptococcosis. In this review, we provide a rationale to support continued investment in Cryptoco...