Inhibition of a metal-dependent viral RNA triphosphatase by decavanadate

• Published in: Biochemical journal Vol. 398; no. 3; pp. 557 - 567
• Main Authors: Bougie, Isabelle, Bisaillon, Martin
• Format: Journal Article
• Language: English
• Published: England Portland Press Ltd 15.09.2006
• Subjects: Acid Anhydride Hydrolases - antagonists & inhibitors; Acid Anhydride Hydrolases - metabolism; Chlorella virus; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Viral; Paramecium bursaria; Paramecium bursaria chlorella virus; Plant Viruses - enzymology; Protein Binding; RNA - metabolism; RNA, Viral - metabolism; Vanadates - pharmacology; Viral Proteins - metabolism

Paramecium bursaria chlorella virus, a large DNA virus that replicates in unicellular Chlorella-like algae, encodes an RNA triphosphatase which is involved in the synthesis of the RNA cap structure found at the 5' end of the viral mRNAs. The Chlorella virus RNA triphosphatase is the smallest me...