Human Immunodeficiency Virus Type 1 (HIV-1)-Specific CD4+ T Cells That Proliferate In Vitro Detected in Samples from Most Viremic Subjects and Inversely Associated with Plasma HIV-1 Levels

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Published inJournal of Virology Vol. 78; no. 22; pp. 12638 - 12646
Main Authors Boritz, Eli, Palmer, Brent E., Wilson, Cara C.
Format Journal Article
LanguageEnglish
Published Washington, DC American Society for Microbiology 01.11.2004
Subjects
Biological and medical sciences
CD4-Positive T-Lymphocytes - immunology
Fundamental and applied biological sciences. Psychology
HIV Core Protein p24 - immunology
HIV-1 - immunology
Human viral diseases
Humans
Infectious diseases
Interferon-gamma - biosynthesis
Interleukin-2 - biosynthesis
Lymphocyte Activation
Lymphocyte Depletion
Medical sciences
Microbiology
Miscellaneous
Pathogenesis and Immunity
RNA, Viral - blood
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
Viremia - immunology
Virology
Virus Replication
Human
Microbiology
HIV-1 virus
Retroviridae
AIDS
Lentivirus
Immune deficiency
In vitro
Blood plasma
Virology
Infection
Virus
Viral disease
Human immunodeficiency virus
Detection
Online AccessGet full text
ISSN0022-538X
1098-5514
DOI10.1128/JVI.78.22.12638-12646.2004

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Abstract Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue Spotlights in the Current Issue JVI About JVI Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy JVI RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0022-538X Online ISSN: 1098-5514 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to JVI .asm.org, visit: JVI       
AbstractList Diminished in vitro proliferation of human immunodeficiency virus type 1 (HIV-1)-specific CD4+T cells has been associated with HIV-1 viremia and declining CD4+ T-cell counts during chronic infection. To better understand this phenomenon, we examined whether HIV-1 Gag p24 antigen-induced CD4+ T-cell proliferation might recover in vitro in a group of subjects with chronic HIV-1 viremia and no history of antiretroviral therapy (ART). We found that depletion of CD8+ cells from peripheral blood mononuclear cells (PBMC) before antigen stimulation was associated with a 6.5-fold increase in the median p24-induced CD4+ T-cell proliferative response and a 57% increase in the number of subjects with positive responses. These p24-induced CD4+ T-cell proliferative responses from CD8-depleted PBMC were associated with expansion of the numbers of p24-specific, gamma interferon (IFN-gamma)-producing CD4+ T cells. Among the 20 viremic, treatment-naive subjects studied, the only 5 subjects lacking proliferation-competent, p24-specific CD4+ T-cell responses from CD8-depleted PBMC showed plasma HIV-1 RNA levels > 100,000 copies/ml. Furthermore, both the magnitude of p24-induced CD4+ T-cell proliferative responses from CD8-depleted PBMC and the frequency of p24-specific, IFN-gamma-producing CD4+ T cells expanded from CD8-depleted PBMC were associated inversely with plasma HIV-1 RNA levels. Therefore, proliferation-competent, HIV-1-specific CD4+ T cells that might help control HIV-1 disease may persist during chronic, progressive HIV-1 disease except at very high levels of in vivo HIV-1 replication.Diminished in vitro proliferation of human immunodeficiency virus type 1 (HIV-1)-specific CD4+T cells has been associated with HIV-1 viremia and declining CD4+ T-cell counts during chronic infection. To better understand this phenomenon, we examined whether HIV-1 Gag p24 antigen-induced CD4+ T-cell proliferation might recover in vitro in a group of subjects with chronic HIV-1 viremia and no history of antiretroviral therapy (ART). We found that depletion of CD8+ cells from peripheral blood mononuclear cells (PBMC) before antigen stimulation was associated with a 6.5-fold increase in the median p24-induced CD4+ T-cell proliferative response and a 57% increase in the number of subjects with positive responses. These p24-induced CD4+ T-cell proliferative responses from CD8-depleted PBMC were associated with expansion of the numbers of p24-specific, gamma interferon (IFN-gamma)-producing CD4+ T cells. Among the 20 viremic, treatment-naive subjects studied, the only 5 subjects lacking proliferation-competent, p24-specific CD4+ T-cell responses from CD8-depleted PBMC showed plasma HIV-1 RNA levels > 100,000 copies/ml. Furthermore, both the magnitude of p24-induced CD4+ T-cell proliferative responses from CD8-depleted PBMC and the frequency of p24-specific, IFN-gamma-producing CD4+ T cells expanded from CD8-depleted PBMC were associated inversely with plasma HIV-1 RNA levels. Therefore, proliferation-competent, HIV-1-specific CD4+ T cells that might help control HIV-1 disease may persist during chronic, progressive HIV-1 disease except at very high levels of in vivo HIV-1 replication.
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Diminished in vitro proliferation of human immunodeficiency virus type 1 (HIV-1)-specific CD4+T cells has been associated with HIV-1 viremia and declining CD4+ T-cell counts during chronic infection. To better understand this phenomenon, we examined whether HIV-1 Gag p24 antigen-induced CD4+ T-cell proliferation might recover in vitro in a group of subjects with chronic HIV-1 viremia and no history of antiretroviral therapy (ART). We found that depletion of CD8+ cells from peripheral blood mononuclear cells (PBMC) before antigen stimulation was associated with a 6.5-fold increase in the median p24-induced CD4+ T-cell proliferative response and a 57% increase in the number of subjects with positive responses. These p24-induced CD4+ T-cell proliferative responses from CD8-depleted PBMC were associated with expansion of the numbers of p24-specific, gamma interferon (IFN-gamma)-producing CD4+ T cells. Among the 20 viremic, treatment-naive subjects studied, the only 5 subjects lacking proliferation-competent, p24-specific CD4+ T-cell responses from CD8-depleted PBMC showed plasma HIV-1 RNA levels > 100,000 copies/ml. Furthermore, both the magnitude of p24-induced CD4+ T-cell proliferative responses from CD8-depleted PBMC and the frequency of p24-specific, IFN-gamma-producing CD4+ T cells expanded from CD8-depleted PBMC were associated inversely with plasma HIV-1 RNA levels. Therefore, proliferation-competent, HIV-1-specific CD4+ T cells that might help control HIV-1 disease may persist during chronic, progressive HIV-1 disease except at very high levels of in vivo HIV-1 replication.
Diminished in vitro proliferation of human immunodeficiency virus type 1 (HIV-1)-specific CD4 + T cells has been associated with HIV-1 viremia and declining CD4 + T-cell counts during chronic infection. To better understand this phenomenon, we examined whether HIV-1 Gag p24 antigen-induced CD4 + T-cell proliferation might recover in vitro in a group of subjects with chronic HIV-1 viremia and no history of antiretroviral therapy (ART). We found that depletion of CD8 + cells from peripheral blood mononuclear cells (PBMC) before antigen stimulation was associated with a 6.5-fold increase in the median p24-induced CD4 + T-cell proliferative response and a 57% increase in the number of subjects with positive responses. These p24-induced CD4 + T-cell proliferative responses from CD8-depleted PBMC were associated with expansion of the numbers of p24-specific, gamma interferon (IFN-γ)-producing CD4 + T cells. Among the 20 viremic, treatment-naïve subjects studied, the only 5 subjects lacking proliferation-competent, p24-specific CD4 + T-cell responses from CD8-depleted PBMC showed plasma HIV-1 RNA levels > 100,000 copies/ml. Furthermore, both the magnitude of p24-induced CD4 + T-cell proliferative responses from CD8-depleted PBMC and the frequency of p24-specific, IFN-γ-producing CD4 + T cells expanded from CD8-depleted PBMC were associated inversely with plasma HIV-1 RNA levels. Therefore, proliferation-competent, HIV-1-specific CD4 + T cells that might help control HIV-1 disease may persist during chronic, progressive HIV-1 disease except at very high levels of in vivo HIV-1 replication.
Diminished in vitro proliferation of human immunodeficiency virus type 1 (HIV-1)-specific CD4 + T cells has been associated with HIV-1 viremia and declining CD4 + T-cell counts during chronic infection. To better understand this phenomenon, we examined whether HIV-1 Gag p24 antigen-induced CD4 + T-cell proliferation might recover in vitro in a group of subjects with chronic HIV-1 viremia and no history of antiretroviral therapy (ART). We found that depletion of CD8 + cells from peripheral blood mononuclear cells (PBMC) before antigen stimulation was associated with a 6.5-fold increase in the median p24-induced CD4 + T-cell proliferative response and a 57% increase in the number of subjects with positive responses. These p24-induced CD4 + T-cell proliferative responses from CD8-depleted PBMC were associated with expansion of the numbers of p24-specific, gamma interferon (IFN-γ)-producing CD4 + T cells. Among the 20 viremic, treatment-naïve subjects studied, the only 5 subjects lacking proliferation-competent, p24-specific CD4 + T-cell responses from CD8-depleted PBMC showed plasma HIV-1 RNA levels > 100,000 copies/ml. Furthermore, both the magnitude of p24-induced CD4 + T-cell proliferative responses from CD8-depleted PBMC and the frequency of p24-specific, IFN-γ-producing CD4 + T cells expanded from CD8-depleted PBMC were associated inversely with plasma HIV-1 RNA levels. Therefore, proliferation-competent, HIV-1-specific CD4 + T cells that might help control HIV-1 disease may persist during chronic, progressive HIV-1 disease except at very high levels of in vivo HIV-1 replication.
Author Eli Boritz
Brent E. Palmer
Cara C. Wilson
AuthorAffiliation Departments of Immunology, 1 Medicine, University of Colorado Health Sciences Center, Denver, Colorado 2
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Cites_doi 10.1128/JVI.75.24.11983-11991.2001
10.1086/381038
10.1038/ni845
10.1073/pnas.95.11.6314
10.1073/pnas.251539598
10.1128/JVI.77.20.10900-10909.2003
10.1073/pnas.89.18.8424
10.1086/318547
10.1084/jem.20031598
10.1126/science.1082305
10.1097/00002030-200005050-00001
10.4049/jimmunol.170.2.1106
10.1016/0165-2478(94)90102-3
10.1038/35035103
10.1086/322859
10.4049/jimmunol.170.1.477
10.1097/00002030-200211220-00012
10.1038/35073658
10.1038/8400
10.4049/jimmunol.169.11.6376
10.1038/nature01441
10.1128/JVI.76.12.5925-5936.2002
10.1086/315764
10.4049/jimmunol.165.3.1685
10.1073/pnas.202372199
10.1002/j.1460-2075.1990.tb08274.x
10.1182/blood-2003-04-1203
10.4049/jimmunol.172.5.3337
10.1038/417095a
10.1128/jvi.68.12.8056-8063.1994
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Keywords Human
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Corresponding author. Mailing address: University of Colorado Health Sciences Center, Campus Box B-164, 4200 East 9th Ave., Denver, CO 80262. Phone: (303) 315-6659. Fax: (303) 315-7642. E-mail: Cara.Wilson@UCHSC.edu.
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References e_1_3_2_27_2
e_1_3_2_28_2
e_1_3_2_29_2
e_1_3_2_20_2
e_1_3_2_21_2
e_1_3_2_22_2
e_1_3_2_23_2
e_1_3_2_24_2
e_1_3_2_25_2
(e_1_3_2_31_2) 1986; 57
e_1_3_2_9_2
e_1_3_2_8_2
e_1_3_2_16_2
e_1_3_2_7_2
e_1_3_2_17_2
e_1_3_2_6_2
e_1_3_2_18_2
e_1_3_2_19_2
e_1_3_2_30_2
e_1_3_2_32_2
e_1_3_2_10_2
e_1_3_2_5_2
e_1_3_2_11_2
e_1_3_2_34_2
e_1_3_2_4_2
e_1_3_2_12_2
e_1_3_2_33_2
e_1_3_2_3_2
e_1_3_2_13_2
e_1_3_2_2_2
e_1_3_2_14_2
(e_1_3_2_26_2) 1995; 7
(e_1_3_2_15_2) 1992; 4
14676302 - J Exp Med. 2003 Dec 15;198(12):1909-22
12594515 - Nature. 2003 Feb 20;421(6925):852-6
11517431 - J Infect Dis. 2001 Sep 15;184(6):707-12
14978142 - J Immunol. 2004 Mar 1;172(5):3337-47
1627788 - Semin Immunol. 1992 Jun;4(3):167-79
14745710 - J Infect Dis. 2004 Feb 1;189(3):515-9
10903780 - J Immunol. 2000 Aug 1;165(3):1685-91
10229228 - Nat Med. 1999 May;5(5):518-25
3082744 - Immunology. 1986 Mar;57(3):351-7
12444145 - J Immunol. 2002 Dec 1;169(11):6376-85
11170979 - J Infect Dis. 2001 Feb 15;183(4):546-54
11717444 - Proc Natl Acad Sci U S A. 2001 Nov 20;98(24):13878-83
12958069 - Blood. 2004 Feb 1;103(3):966-72
11029005 - Nature. 2000 Sep 28;407(6803):523-6
8137559 - Clin Immunol Immunopathol. 1994 Apr;71(1):60-8
10839583 - AIDS. 2000 May 5;14(7):761-70
11362161 - AIDS Clin Care. 1995 Jan;7(1):1-3
1388269 - Proc Natl Acad Sci U S A. 1992 Sep 15;89(18):8424-8
12690201 - Science. 2003 Apr 11;300(5617):337-9
11309628 - Nature. 2001 Apr 19;410(6831):980-7
7966595 - J Virol. 1994 Dec;68(12):8056-63
9600962 - Proc Natl Acad Sci U S A. 1998 May 26;95(11):6314-9
12496434 - J Immunol. 2003 Jan 1;170(1):477-86
11711588 - J Virol. 2001 Dec;75(24):11983-91
12441804 - AIDS. 2002 Nov 22;16(17):2317-22
2184033 - EMBO J. 1990 May;9(5):1551-60
12021325 - J Virol. 2002 Jun;76(12):5925-36
12517980 - J Immunol. 2003 Jan 15;170(2):1106-16
14512540 - J Virol. 2003 Oct;77(20):10900-9
10950773 - J Infect Dis. 2000 Sep;182(3):792-8
12368910 - Nat Immunol. 2002 Nov;3(11):1061-8
11986671 - Nature. 2002 May 2;417(6884):95-8
12370434 - Proc Natl Acad Sci U S A. 2002 Oct 15;99(21):13747-52
References_xml – ident: e_1_3_2_4_2
  doi: 10.1128/JVI.75.24.11983-11991.2001
– ident: e_1_3_2_16_2
  doi: 10.1086/381038
– ident: e_1_3_2_20_2
  doi: 10.1038/ni845
– volume: 7
  start-page: 1
  year: 1995
  ident: e_1_3_2_26_2
  publication-title: AIDS Clin. Care
– ident: e_1_3_2_11_2
  doi: 10.1073/pnas.95.11.6314
– ident: e_1_3_2_19_2
  doi: 10.1073/pnas.251539598
– ident: e_1_3_2_13_2
  doi: 10.1128/JVI.77.20.10900-10909.2003
– ident: e_1_3_2_7_2
  doi: 10.1073/pnas.89.18.8424
– ident: e_1_3_2_3_2
  doi: 10.1086/318547
– ident: e_1_3_2_34_2
  doi: 10.1084/jem.20031598
– ident: e_1_3_2_28_2
  doi: 10.1126/science.1082305
– ident: e_1_3_2_2_2
  doi: 10.1097/00002030-200005050-00001
– ident: e_1_3_2_6_2
  doi: 10.4049/jimmunol.170.2.1106
– ident: e_1_3_2_30_2
  doi: 10.1016/0165-2478(94)90102-3
– ident: e_1_3_2_27_2
  doi: 10.1038/35035103
– ident: e_1_3_2_32_2
  doi: 10.1086/322859
– ident: e_1_3_2_10_2
  doi: 10.4049/jimmunol.170.1.477
– ident: e_1_3_2_21_2
  doi: 10.1097/00002030-200211220-00012
– ident: e_1_3_2_18_2
  doi: 10.1038/35073658
– ident: e_1_3_2_25_2
  doi: 10.1038/8400
– ident: e_1_3_2_5_2
  doi: 10.4049/jimmunol.169.11.6376
– ident: e_1_3_2_14_2
  doi: 10.1038/nature01441
– ident: e_1_3_2_23_2
  doi: 10.1128/JVI.76.12.5925-5936.2002
– ident: e_1_3_2_33_2
  doi: 10.1086/315764
– ident: e_1_3_2_9_2
  doi: 10.4049/jimmunol.165.3.1685
– volume: 4
  start-page: 167
  year: 1992
  ident: e_1_3_2_15_2
  publication-title: Semin. Immunol.
– ident: e_1_3_2_22_2
  doi: 10.1073/pnas.202372199
– ident: e_1_3_2_29_2
  doi: 10.1002/j.1460-2075.1990.tb08274.x
– ident: e_1_3_2_12_2
  doi: 10.1182/blood-2003-04-1203
– ident: e_1_3_2_24_2
  doi: 10.4049/jimmunol.172.5.3337
– ident: e_1_3_2_8_2
  doi: 10.1038/417095a
– volume: 57
  start-page: 351
  year: 1986
  ident: e_1_3_2_31_2
  publication-title: Immunology
– ident: e_1_3_2_17_2
  doi: 10.1128/jvi.68.12.8056-8063.1994
– reference: 14745710 - J Infect Dis. 2004 Feb 1;189(3):515-9
– reference: 8137559 - Clin Immunol Immunopathol. 1994 Apr;71(1):60-8
– reference: 11517431 - J Infect Dis. 2001 Sep 15;184(6):707-12
– reference: 10229228 - Nat Med. 1999 May;5(5):518-25
– reference: 11170979 - J Infect Dis. 2001 Feb 15;183(4):546-54
– reference: 14978142 - J Immunol. 2004 Mar 1;172(5):3337-47
– reference: 10950773 - J Infect Dis. 2000 Sep;182(3):792-8
– reference: 12517980 - J Immunol. 2003 Jan 15;170(2):1106-16
– reference: 11362161 - AIDS Clin Care. 1995 Jan;7(1):1-3
– reference: 2184033 - EMBO J. 1990 May;9(5):1551-60
– reference: 11309628 - Nature. 2001 Apr 19;410(6831):980-7
– reference: 12444145 - J Immunol. 2002 Dec 1;169(11):6376-85
– reference: 3082744 - Immunology. 1986 Mar;57(3):351-7
– reference: 12441804 - AIDS. 2002 Nov 22;16(17):2317-22
– reference: 12690201 - Science. 2003 Apr 11;300(5617):337-9
– reference: 12368910 - Nat Immunol. 2002 Nov;3(11):1061-8
– reference: 11717444 - Proc Natl Acad Sci U S A. 2001 Nov 20;98(24):13878-83
– reference: 10839583 - AIDS. 2000 May 5;14(7):761-70
– reference: 1627788 - Semin Immunol. 1992 Jun;4(3):167-79
– reference: 7966595 - J Virol. 1994 Dec;68(12):8056-63
– reference: 12496434 - J Immunol. 2003 Jan 1;170(1):477-86
– reference: 10903780 - J Immunol. 2000 Aug 1;165(3):1685-91
– reference: 12958069 - Blood. 2004 Feb 1;103(3):966-72
– reference: 12594515 - Nature. 2003 Feb 20;421(6925):852-6
– reference: 1388269 - Proc Natl Acad Sci U S A. 1992 Sep 15;89(18):8424-8
– reference: 11711588 - J Virol. 2001 Dec;75(24):11983-91
– reference: 11986671 - Nature. 2002 May 2;417(6884):95-8
– reference: 9600962 - Proc Natl Acad Sci U S A. 1998 May 26;95(11):6314-9
– reference: 12021325 - J Virol. 2002 Jun;76(12):5925-36
– reference: 12370434 - Proc Natl Acad Sci U S A. 2002 Oct 15;99(21):13747-52
– reference: 14512540 - J Virol. 2003 Oct;77(20):10900-9
– reference: 14676302 - J Exp Med. 2003 Dec 15;198(12):1909-22
– reference: 11029005 - Nature. 2000 Sep 28;407(6803):523-6
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Diminished in vitro proliferation of human immunodeficiency virus type 1 (HIV-1)-specific CD4 + T cells has been associated with HIV-1 viremia and declining...
Diminished in vitro proliferation of human immunodeficiency virus type 1 (HIV-1)-specific CD4+T cells has been associated with HIV-1 viremia and declining CD4+...
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StartPage 12638
SubjectTerms Biological and medical sciences
CD4-Positive T-Lymphocytes - immunology
Fundamental and applied biological sciences. Psychology
HIV Core Protein p24 - immunology
HIV-1 - immunology
Human viral diseases
Humans
Infectious diseases
Interferon-gamma - biosynthesis
Interleukin-2 - biosynthesis
Lymphocyte Activation
Lymphocyte Depletion
Medical sciences
Microbiology
Miscellaneous
Pathogenesis and Immunity
RNA, Viral - blood
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
Viremia - immunology
Virology
Virus Replication
Title Human Immunodeficiency Virus Type 1 (HIV-1)-Specific CD4+ T Cells That Proliferate In Vitro Detected in Samples from Most Viremic Subjects and Inversely Associated with Plasma HIV-1 Levels
URI http://jvi.asm.org/content/78/22/12638.abstract
https://www.ncbi.nlm.nih.gov/pubmed/15507650
https://www.proquest.com/docview/67017176
https://pubmed.ncbi.nlm.nih.gov/PMC525069
Volume 78
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