Sonoporation delivery of interleukin-27 gene therapy efficiently reduces prostate tumor cell growth in vivo

• Published in: Human gene therapy Vol. 22; no. 12; p. 1537
• Main Authors: Zolochevska, Olga, Xia, Xueqing, Williams, B Jill, Ramsay, Alistair, Li, Shulin, Figueiredo, Marxa L
• Format: Journal Article
• Language: English
• Published: United States 01.12.2011
• Subjects: Animals; Blotting, Western; Cell Adhesion; Cell Movement; Cell Proliferation; Drug Delivery Systems - methods; Flow Cytometry; Gene Transfer Techniques; Genetic Therapy; Humans; Interleukin-17 - genetics; Luminescence; Male; Mice; Mice, Inbred C57BL; Prostatic Neoplasms - genetics; Prostatic Neoplasms - therapy; Real-Time Polymerase Chain Reaction; RNA, Messenger - genetics; Tumor Cells, Cultured; Ultrasonics

We have examined the potential of a novel cytokine, interleukin-27 (IL-27), for gene therapy of prostate cancer. IL-27 is the most recently characterized member of the family of heterodimeric IL-12-related cytokines and has shown promise in halting tumor growth and mediating tumor regression in seve...