Age-specific changes in the molecular phenotype of patients with moderate-to-severe atopic dermatitis

• Published in: Journal of allergy and clinical immunology Vol. 144; no. 1; pp. 144 - 156
• Main Authors: Zhou, Lisa, Leonard, Alexandra, Pavel, Ana B., Malik, Kunal, Raja, Aishwarya, Glickman, Jacob, Estrada, Yeriel D., Peng, Xiangyu, del Duca, Ester, Sanz-Cabanillas, Juan, Ruano, Juan, Xu, Hui, Zhang, Ning, Wen, Huei-Chi, Gonzalez, Juana, Garcet, Sandra, Krueger, James G., Guttman-Yassky, Emma
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.07.2019; Elsevier Limited
• Subjects: Adolescent; Adult; Age groups; Aged; Aged, 80 and over; aging; Aging - blood; Aging - genetics; Aging - immunology; Atopic dermatitis; biomarker; Biopsy; CCL18 protein; Cytokines - genetics; Cytokines - immunology; Dendritic cells; Dermatitis; Dermatitis, Atopic - blood; Dermatitis, Atopic - genetics; Dermatitis, Atopic - immunology; Dermatitis, Atopic - pathology; Disease; Eczema; FDA approval; Female; Filaggrin; Gene Expression; Helper cells; Humans; Hyperplasia; Hypothesis testing; Immunoglobulin E; Immunohistochemistry; Interleukin 1; Interleukin 12; Interleukin 13; Interleukin 20; Interleukin 22; Interleukin 5; Keratin; Leukocytes (eosinophilic); loricrin; Lymphocytes T; Male; Middle Aged; Mutation; Patients; Pediatrics; Phenotype; Phenotypes; Psoriasis; Severity of Illness Index; Skin; Skin - immunology; Skin - pathology; Software; Stat1 protein; Statistical analysis; TH1; TH17; TH2; TH22; Young Adult; γ-Interferon; FLG; AD; IHC; qRT-PCR; Treg; skin; FCH; biomarker; FOXP3; LOR; ET; MMP12; K16; STAT; TH22; Atopic dermatitis; hyperplasia; aging; TH1; TH17; filaggrin; TH2; loricrin; DC; T(H)17; T(H)22; T(H)1; T(H)2

Atopic dermatitis (AD) shows differential clinical presentation in older compared with younger patients. Nevertheless, changes in the AD molecular profile with age are unknown. We sought to characterize age-related changes in the AD profile. We evaluated age-specific changes in lesional and nonlesio...