Multiple Sclerosis: Comparison of Copolymer-1-Reactive T Cell Lines from Treated and Untreated Subjects Reveals Cytokine Shift from T Helper 1 to T Helper 2 Cells

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 97; no. 13; pp. 7452 - 7457
• Main Authors: Neuhaus, Oliver, Farina, Cinthia, Yassouridis, Alexander, Wiendl, Heinz, Bergh, Florian Then, Dose, Tatjana, Wekerle, Hartmut, Hohlfeld, Reinhard
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences of the United States of America 20.06.2000; National Acad Sciences; National Academy of Sciences; The National Academy of Sciences
• Subjects: Adolescent; Adult; Antigens; Biological Sciences; Cell Differentiation - immunology; Cell lines; Cells; Cloning; copolymer 1; Cryptogenic organizing pneumonia; Cytokines; Cytokines - immunology; Cytometry; Female; Glatiramer Acetate; Humans; Male; Middle Aged; Multiple sclerosis; Multiple Sclerosis - drug therapy; Multiple Sclerosis - immunology; Neurology; Peptides; Peptides - immunology; Peptides - therapeutic use; Polymers; Secretion; T cell antigen receptors; T lymphocytes; Th1 Cells - immunology; Th2 Cells - immunology

Copolymer 1 (COP), a standardized mixture of synthetic polypeptides consisting of L-glutamic acid, L-lysine, L-alanine, and L-tyrosine, has beneficial effects in multiple sclerosis and experimental autoimmune encephalomyelitis. We selected a panel of 721 COP-reactive T cell lines (TCL) from the bloo...