Population pharmacokinetic modeling and simulation of huperzine A in elderly Chinese subjects

• Published in: Acta pharmacologica Sinica Vol. 37; no. 7; pp. 994 - 1001
• Main Authors: Sheng, Lei, Qu, Yi, Yan, Jing, Liu, Gang-yi, Wang, Wei-liang, Wang, Yi-jun, Wang, Hong-yi, Zhang, Meng-qi, Lu, Chuan, Liu, Yun, Jia, Jing-yin, Hu, Chao-ying, Li, Xue-ning, Yu, Chen, Xu, Hong-rong
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.07.2016; Nature Publishing Group
• Subjects: Aged; Aged, 80 and over; Aging - blood; Alkaloids - administration & dosage; Alkaloids - blood; Alkaloids - pharmacokinetics; Asian Continental Ancestry Group; Biomedical and Life Sciences; Biomedicine; Body Height; Body Weight; Creatinine - urine; Female; Humans; Immunology; Internal Medicine; Male; Medical Microbiology; Middle Aged; Models, Biological; Nonlinear Dynamics; Original; original-article; Pharmacology/Toxicology; Sesquiterpenes - administration & dosage; Sesquiterpenes - blood; Sesquiterpenes - pharmacokinetics; Sex Characteristics; Vaccine; modeling and simulation; elderly Chinese people; NLME; Alzheimer's disease; huperzine A; population pharmacokinetics

Aim: Our preliminary results show that huperzine A, an acetylcholinesterase inhibitor used to treat Alzheimer's disease (AD) patients in China, exhibits different pharmacokinetic features in elderly and young healthy subjects. However, its pharmacokinetic data in elderly subjects remains unavai...