DNA tumor virus oncogenes antagonize the cGAS-STING DNA-sensing pathway

• Published in: Science (American Association for the Advancement of Science) Vol. 350; no. 6260; pp. 568 - 571
• Main Authors: Lau, Laura, Gray, Elizabeth E., Brunette, Rebecca L., Stetson, Daniel B.
• Format: Journal Article
• Language: English
• Published: United States American Association for the Advancement of Science 30.10.2015; The American Association for the Advancement of Science
• Subjects: Adenoviridae; Adenovirus; Adenovirus E1A Proteins - chemistry; Adenovirus E1A Proteins - genetics; Adenovirus E1A Proteins - metabolism; Amino Acid Motifs; Amino Acid Sequence; Cancer; Deoxyribonucleic acid; DNA; DNA Tumor Viruses - immunology; DNA, Neoplasm - immunology; DNA-Binding Proteins - chemistry; DNA-Binding Proteins - genetics; DNA-Binding Proteins - metabolism; Evolution; Evolution, Molecular; Genes; HEK293 Cells; HeLa Cells; Host-Pathogen Interactions; Human adenovirus; Human papillomavirus; Humans; Immune system; Membrane Proteins - antagonists & inhibitors; Metabolic Networks and Pathways; Molecular Sequence Data; Nucleotides, Cyclic - antagonists & inhibitors; Oncogene Proteins, Viral - chemistry; Oncogene Proteins, Viral - genetics; Oncogene Proteins, Viral - metabolism; Oncology; Papillomaviridae; Pathways; Proteins; Retinoblastoma Protein - antagonists & inhibitors; Suppressors; Tumor Escape; Tumors; Viruses
• ISSN: 0036-8075; 1095-9203
• DOI: 10.1126/science.aab3291

Cyclic guanosine monophosphate–adenosine monophosphate synthase (cGAS) detects intracellular DNA and signals through the adapter protein STING to initiate the antiviral response to DNA viruses. Whether DNA viruses can prevent activation of the cGAS-STING pathway remains largely unknown. Here, we ide...