Polymorphisms in interleukin-1 receptor-associated kinase 4 are associated with total serum IgE

• Published in: Allergy Vol. 64; no. 5; pp. 746 - 753
• Main Authors: Tewfik, M.A, Bossé, Y, Lemire, M, Hudson, T.J, Vallée-Smejda, S, Al-Shemari, H, Laprise, C, Desrosiers, M
• Format: Journal Article
• Language: English
• Published: Oxford, UK Oxford, UK : Blackwell Publishing Ltd 01.05.2009; Blackwell Publishing Ltd; Blackwell
• Subjects: Adult; Allergies; asthma; Biological and medical sciences; Chronic Disease; Chronic obstructive pulmonary disease, asthma; chronic rhinosinusitis; Cross-Sectional Studies; Cytokines; Dermatology; Female; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Gene Frequency - genetics; Gene Frequency - immunology; genetics innate immunity; Genotype; Genotype & phenotype; Humans; Hypersensitivity - genetics; Hypersensitivity - immunology; Immune system; immunoglobulin E; Immunoglobulin E - blood; Immunoglobulins; Interleukin-1 Receptor-Associated Kinases - genetics; Interleukin-1 Receptor-Associated Kinases - immunology; Linkage Disequilibrium; Male; Medical sciences; Middle Aged; Pneumology; Polymorphism; Polymorphism, Single Nucleotide; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis; Surveys and Questionnaires; Nose disease; Genetic variability; Rhinitis; IgE; Natural immunity; Sinusitis; Association; Immunology; ENT disease; Bronchus disease; Genetics; Serum; genetics innate immunity; Obstructive pulmonary disease; Interleukin 1 receptor; Lung disease; Immunopathology; Enzyme; Respiratory disease; Dermatology; Transferases; Genotype; immunoglobulin E; Asthma; Chronic; Kinase; chronic rhinosinusitis; Paranasal sinus disease; Polymorphism

Serum immunoglobulin E (IgE) level is recognized to be under strong genetic control, but the causal and susceptibility genes remain to be identified. We sought to investigate the association between single nucleotide polymorphisms (SNPs) in the Toll-like receptor (TLR) signaling pathway and total se...