Cyclodextrin Prevents Abdominal Aortic Aneurysm via Activation of Vascular Smooth Muscle Cell Transcription Factor EB

• Published in: Circulation (New York, N.Y.) Vol. 142; no. 5; pp. 483 - 498
• Main Authors: Lu, Haocheng, Sun, Jinjian, Liang, Wenying, Chang, Ziyi, Rom, Oren, Zhao, Yang, Zhao, Guizhen, Xiong, Wenhao, Wang, Huilun, Zhu, Tianqing, Guo, Yanhong, Chang, Lin, Garcia-Barrio, Minerva T., Zhang, Jifeng, Chen, Y. Eugene, Fan, Yanbo
• Format: Journal Article
• Language: English
• Published: United States by the American College of Cardiology Foundation and the American Heart Association, Inc 04.08.2020
• Subjects: 2-Hydroxypropyl-beta-cyclodextrin - pharmacology; 2-Hydroxypropyl-beta-cyclodextrin - therapeutic use; Aminopropionitrile - toxicity; Aneurysm, Ruptured - etiology; Angiotensin II - toxicity; Animals; Aortic Aneurysm, Abdominal - genetics; Aortic Aneurysm, Abdominal - metabolism; Aortic Aneurysm, Abdominal - prevention & control; Apoptosis - drug effects; Autophagy; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - biosynthesis; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - deficiency; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - genetics; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - physiology; Cholesterol - metabolism; Disease Models, Animal; Down-Regulation; Drug Evaluation, Preclinical; Gain of Function Mutation; Gene Expression Regulation; Genetic Vectors - toxicity; Humans; Loss of Function Mutation; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle, Smooth, Vascular - drug effects; Muscle, Smooth, Vascular - physiology; Myocytes, Smooth Muscle - drug effects; Myocytes, Smooth Muscle - physiology; Promoter Regions, Genetic; Proto-Oncogene Proteins c-bcl-2 - genetics; Proto-Oncogene Proteins c-bcl-2 - physiology; Transcriptome - drug effects; apoptosis; myocytes, smooth muscle; autophagy; aortic aneurysm, abdominal

Abdominal aortic aneurysm (AAA) is a severe aortic disease with a high mortality rate in the event of rupture. Pharmacological therapy is needed to inhibit AAA expansion and prevent aneurysm rupture. Transcription factor EB (TFEB), a master regulator of autophagy and lysosome biogenesis, is critical...