Cyclodextrin Prevents Abdominal Aortic Aneurysm via Activation of Vascular Smooth Muscle Cell Transcription Factor EB - Lu, Haocheng; Sun, Jinjian; Liang, Wenying; Chang, Ziyi; Rom, Oren; Zhao, Yang; Zhao, Guizhen; Xiong, Wenhao; Wang, Huilun; Zhu, Tianqing; Guo, Yanhong; Chang, Lin; et al. (Circulation (New York, N.Y.), 2020)
Keywords: 2-Hydroxypropyl-beta-cyclodextrin - pharmacology; 2-Hydroxypropyl-beta-cyclodextrin - therapeutic use; Aminopropionitrile - toxicity; Aneurysm, Ruptured - etiology; Angiotensin II - toxicity; Animals; Aortic Aneurysm, Abdominal - genetics; Aortic Aneurysm, Abdominal - metabolism; Aortic Aneurysm, Abdominal - prevention & control; Apoptosis - drug effects; Autophagy; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - biosynthesis; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - deficiency; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - genetics; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - physiology; Cholesterol - metabolism; Disease Models, Animal; Down-Regulation; Drug Evaluation, Preclinical; Gain of Function Mutation; Gene Expression Regulation; Genetic Vectors - toxicity; Humans; Loss of Function Mutation; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle, Smooth, Vascular - drug effects; Muscle, Smooth, Vascular - physiology; Myocytes, Smooth Muscle - drug effects; Myocytes, Smooth Muscle - physiology; Promoter Regions, Genetic; Proto-Oncogene Proteins c-bcl-2 - genetics; Proto-Oncogene Proteins c-bcl-2 - physiology; Transcriptome - drug effects; apoptosis; myocytes, smooth muscle; autophagy; aortic aneurysm, abdominal