Long-Term DHEA Replacement in Primary Adrenal Insufficiency: A Randomized, Controlled Trial

• Published in: The journal of clinical endocrinology and metabolism Vol. 93; no. 2; pp. 400 - 409
• Main Authors: Gurnell, Eleanor M., Hunt, Penelope J., Curran, Suzanne E., Conway, Catherine L., Pullenayegum, Eleanor M., Huppert, Felicia A., Compston, Juliet E., Herbert, Joseph, Chatterjee, V. Krishna K.
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Oxford University Press 01.02.2008; Copyright by The Endocrine Society; Endocrine Society; The Endocrine Society
• Subjects: Absorptiometry, Photon; Addison Disease - blood; Addison Disease - drug therapy; Adrenals. Adrenal axis. Renin-angiotensin system (diseases); Adult; Aged; Androstenedione; Biological and medical sciences; Blindness; Body composition; Body Composition - drug effects; Body fat; Bone composition; Bone density; Bone Density - drug effects; Bone mass; Bone mineral density; Cognition - drug effects; Cognitive ability; Dehydroepiandrosterone; Dehydroepiandrosterone - therapeutic use; Dehydroepiandrosterone sulfate; Dehydroepiandrosterone Sulfate - blood; Double-Blind Method; Endocrinopathies; Fatigue; Feeding. Feeding behavior; Female; Females; Fundamental and applied biological sciences. Psychology; Hormone Replacement Therapy - methods; Humans; Male; Medical sciences; Middle Aged; Non tumoral diseases. Target tissue resistance. Benign neoplasms; Original; Prospective Studies; Quality of Life; Sex hormones; Statistics, Nonparametric; Steroid hormones; Surveys and Questionnaires; Testosterone; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Vertebrates: endocrinology; Endocrinopathy; Obesity; Nutrition; Nutrition disorder; Metabolic diseases; Replacement; Long term; Randomized controlled trial; Dehydroepiandrosterone; Randomization; Adrenal insufficiency; Adrenal gland diseases; Primary; Clinical trial; Endocrinology; Nutritional status

Context: Dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS) are the major circulating adrenal steroids and substrates for peripheral sex hormone biosynthesis. In Addison’s disease, glucocorticoid and mineralocorticoid deficiencies require lifelong replacement, but the associated near-total failu...