Long-Term Results of the RAPCO Trials
BACKGROUND:An internal thoracic artery graft to the left anterior descending artery is standard in coronary bypass surgery, but controversy exists on the best second conduit. The RAPCO trials (Radial Artery Patency and Clinical Outcomes) were designed to compare the long-term patency of the radial a...
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Published in | Circulation (New York, N.Y.) Vol. 142; no. 14; pp. 1330 - 1338 |
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Main Authors | , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
by the American College of Cardiology Foundation and the American Heart Association, Inc
06.10.2020
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Subjects | |
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Abstract | BACKGROUND:An internal thoracic artery graft to the left anterior descending artery is standard in coronary bypass surgery, but controversy exists on the best second conduit. The RAPCO trials (Radial Artery Patency and Clinical Outcomes) were designed to compare the long-term patency of the radial artery (RA) with that of the right internal thoracic artery (RITA) and the saphenous vein (SV).
METHODS:In RAPCO-RITA (the RITA versus RA arm of the RAPCO trial), 394 patients <70 years of age (or <60 years of age if they had diabetes mellitus) were randomized to receive RA or free RITA graft on the second most important coronary target. In RAPCO-SV (the SV versus RA arm of the RAPCO trial), 225 patients ≥70 years of age (or ≥60 years of age if they had diabetes mellitus) were randomized to receive RA or SV graft. The primary outcome was 10-year graft failure. Long-term mortality was a nonpowered coprimary end point. The main analysis was by intention to treat.
RESULTS:In the RA versus RITA comparison, the estimated 10-year patency was 89% for RA versus 80% for free RITA (hazard ratio for graft failure, 0.45 [95% CI, 0.23–0.88]). Ten-year patient survival estimate was 90.9% in the RA arm versus 83.7% in the RITA arm (hazard ratio for mortality, 0.53 [95% CI, 0.30–0.95]). In the RA versus SV comparison, the estimated 10-year patency was 85% for the RA versus 71% for the SV (hazard ratio for graft failure, 0.40 [95% CI, 0.15–1.00]), and 10-year patient survival estimate was 72.6% for the RA group versus 65.2% for the SV group (hazard ratio for mortality, 0.76 [95% CI, 0.47–1.22]).
CONCLUSIONS:The 10-year patency rate of the RA is significantly higher than that of the free RITA and better than that of the SV.
REGISTRATION:URLhttps://www.clinicaltrials.gov; Unique identifierNCT00475488. |
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AbstractList | An internal thoracic artery graft to the left anterior descending artery is standard in coronary bypass surgery, but controversy exists on the best second conduit. The RAPCO trials (Radial Artery Patency and Clinical Outcomes) were designed to compare the long-term patency of the radial artery (RA) with that of the right internal thoracic artery (RITA) and the saphenous vein (SV).
In RAPCO-RITA (the RITA versus RA arm of the RAPCO trial), 394 patients <70 years of age (or <60 years of age if they had diabetes mellitus) were randomized to receive RA or free RITA graft on the second most important coronary target. In RAPCO-SV (the SV versus RA arm of the RAPCO trial), 225 patients ≥70 years of age (or ≥60 years of age if they had diabetes mellitus) were randomized to receive RA or SV graft. The primary outcome was 10-year graft failure. Long-term mortality was a nonpowered coprimary end point. The main analysis was by intention to treat.
In the RA versus RITA comparison, the estimated 10-year patency was 89% for RA versus 80% for free RITA (hazard ratio for graft failure, 0.45 [95% CI, 0.23-0.88]). Ten-year patient survival estimate was 90.9% in the RA arm versus 83.7% in the RITA arm (hazard ratio for mortality, 0.53 [95% CI, 0.30-0.95]). In the RA versus SV comparison, the estimated 10-year patency was 85% for the RA versus 71% for the SV (hazard ratio for graft failure, 0.40 [95% CI, 0.15-1.00]), and 10-year patient survival estimate was 72.6% for the RA group versus 65.2% for the SV group (hazard ratio for mortality, 0.76 [95% CI, 0.47-1.22]).
The 10-year patency rate of the RA is significantly higher than that of the free RITA and better than that of the SV. Registration: URL: https://www.clinicaltrials.gov; Unique identifier: NCT00475488. Background: An internal thoracic artery graft to the left anterior descending artery is standard in coronary bypass surgery, but controversy exists on the best second conduit. The RAPCO trials (Radial Artery Patency and Clinical Outcomes) were designed to compare the long-term patency of the radial artery (RA) with that of the right internal thoracic artery (RITA) and the saphenous vein (SV). Methods: In RAPCO-RITA (the RITA versus RA arm of the RAPCO trial), 394 patients <70 years of age (or <60 years of age if they had diabetes mellitus) were randomized to receive RA or free RITA graft on the second most important coronary target. In RAPCO-SV (the SV versus RA arm of the RAPCO trial), 225 patients ≥70 years of age (or ≥60 years of age if they had diabetes mellitus) were randomized to receive RA or SV graft. The primary outcome was 10-year graft failure. Long-term mortality was a nonpowered coprimary end point. The main analysis was by intention to treat. Results: In the RA versus RITA comparison, the estimated 10-year patency was 89% for RA versus 80% for free RITA (hazard ratio for graft failure, 0.45 [95% CI, 0.23–0.88]). Ten-year patient survival estimate was 90.9% in the RA arm versus 83.7% in the RITA arm (hazard ratio for mortality, 0.53 [95% CI, 0.30–0.95]). In the RA versus SV comparison, the estimated 10-year patency was 85% for the RA versus 71% for the SV (hazard ratio for graft failure, 0.40 [95% CI, 0.15–1.00]), and 10-year patient survival estimate was 72.6% for the RA group versus 65.2% for the SV group (hazard ratio for mortality, 0.76 [95% CI, 0.47–1.22]). Conclusions: The 10-year patency rate of the RA is significantly higher than that of the free RITA and better than that of the SV. Registration: URL: https://www.clinicaltrials.gov ; Unique identifier: NCT00475488. BACKGROUNDAn internal thoracic artery graft to the left anterior descending artery is standard in coronary bypass surgery, but controversy exists on the best second conduit. The RAPCO trials (Radial Artery Patency and Clinical Outcomes) were designed to compare the long-term patency of the radial artery (RA) with that of the right internal thoracic artery (RITA) and the saphenous vein (SV). METHODSIn RAPCO-RITA (the RITA versus RA arm of the RAPCO trial), 394 patients <70 years of age (or <60 years of age if they had diabetes mellitus) were randomized to receive RA or free RITA graft on the second most important coronary target. In RAPCO-SV (the SV versus RA arm of the RAPCO trial), 225 patients ≥70 years of age (or ≥60 years of age if they had diabetes mellitus) were randomized to receive RA or SV graft. The primary outcome was 10-year graft failure. Long-term mortality was a nonpowered coprimary end point. The main analysis was by intention to treat. RESULTSIn the RA versus RITA comparison, the estimated 10-year patency was 89% for RA versus 80% for free RITA (hazard ratio for graft failure, 0.45 [95% CI, 0.23-0.88]). Ten-year patient survival estimate was 90.9% in the RA arm versus 83.7% in the RITA arm (hazard ratio for mortality, 0.53 [95% CI, 0.30-0.95]). In the RA versus SV comparison, the estimated 10-year patency was 85% for the RA versus 71% for the SV (hazard ratio for graft failure, 0.40 [95% CI, 0.15-1.00]), and 10-year patient survival estimate was 72.6% for the RA group versus 65.2% for the SV group (hazard ratio for mortality, 0.76 [95% CI, 0.47-1.22]). CONCLUSIONSThe 10-year patency rate of the RA is significantly higher than that of the free RITA and better than that of the SV. Registration: URL: https://www.clinicaltrials.gov; Unique identifier: NCT00475488. BACKGROUND:An internal thoracic artery graft to the left anterior descending artery is standard in coronary bypass surgery, but controversy exists on the best second conduit. The RAPCO trials (Radial Artery Patency and Clinical Outcomes) were designed to compare the long-term patency of the radial artery (RA) with that of the right internal thoracic artery (RITA) and the saphenous vein (SV). METHODS:In RAPCO-RITA (the RITA versus RA arm of the RAPCO trial), 394 patients <70 years of age (or <60 years of age if they had diabetes mellitus) were randomized to receive RA or free RITA graft on the second most important coronary target. In RAPCO-SV (the SV versus RA arm of the RAPCO trial), 225 patients ≥70 years of age (or ≥60 years of age if they had diabetes mellitus) were randomized to receive RA or SV graft. The primary outcome was 10-year graft failure. Long-term mortality was a nonpowered coprimary end point. The main analysis was by intention to treat. RESULTS:In the RA versus RITA comparison, the estimated 10-year patency was 89% for RA versus 80% for free RITA (hazard ratio for graft failure, 0.45 [95% CI, 0.23–0.88]). Ten-year patient survival estimate was 90.9% in the RA arm versus 83.7% in the RITA arm (hazard ratio for mortality, 0.53 [95% CI, 0.30–0.95]). In the RA versus SV comparison, the estimated 10-year patency was 85% for the RA versus 71% for the SV (hazard ratio for graft failure, 0.40 [95% CI, 0.15–1.00]), and 10-year patient survival estimate was 72.6% for the RA group versus 65.2% for the SV group (hazard ratio for mortality, 0.76 [95% CI, 0.47–1.22]). CONCLUSIONS:The 10-year patency rate of the RA is significantly higher than that of the free RITA and better than that of the SV. REGISTRATION:URLhttps://www.clinicaltrials.gov; Unique identifierNCT00475488. |
Author | Hayward, Philip A Gordon, Ian Benedetto, Umberto Hare, David L Raman, Jai Matalanis, George Moten, Simon C Seevanayagam, Siven Buxton, Brian F Rosalion, Alexander Gaudino, Mario |
AuthorAffiliation | Department of Cardiac Surgery, Austin Hospital, Melbourne, Australia (B.F.B., J.R., S.C.M., S.S., G.M.). Faculty of Medicine, Dentistry and Health Sciences (B.F.B., P.A.H., J.R., A.R., S.S., G.M., D.L.H.), University of Melbourne, Australia. Statistical Consulting Centre (I.G.), University of Melbourne, Australia. Bristol Heart Institute, University of Bristol, United Kingdom (U.B.). Department of Cardiothoracic Surgery, Weill Cornell Medicine, New York, NY (M.G.). Department of Cardiology, Austin Health, Melbourne, Australia (D.L.H.) |
AuthorAffiliation_xml | – name: Department of Cardiac Surgery, Austin Hospital, Melbourne, Australia (B.F.B., J.R., S.C.M., S.S., G.M.). Faculty of Medicine, Dentistry and Health Sciences (B.F.B., P.A.H., J.R., A.R., S.S., G.M., D.L.H.), University of Melbourne, Australia. Statistical Consulting Centre (I.G.), University of Melbourne, Australia. Bristol Heart Institute, University of Bristol, United Kingdom (U.B.). Department of Cardiothoracic Surgery, Weill Cornell Medicine, New York, NY (M.G.). Department of Cardiology, Austin Health, Melbourne, Australia (D.L.H.) |
Author_xml | – sequence: 1 givenname: Brian surname: Buxton middlename: F fullname: Buxton, Brian F organization: Department of Cardiac Surgery, Austin Hospital, Melbourne, Australia (B.F.B., J.R., S.C.M., S.S., G.M.). Faculty of Medicine, Dentistry and Health Sciences (B.F.B., P.A.H., J.R., A.R., S.S., G.M., D.L.H.), University of Melbourne, Australia. Statistical Consulting Centre (I.G.), University of Melbourne, Australia. Bristol Heart Institute, University of Bristol, United Kingdom (U.B.). Department of Cardiothoracic Surgery, Weill Cornell Medicine, New York, NY (M.G.). Department of Cardiology, Austin Health, Melbourne, Australia (D.L.H.) – sequence: 2 givenname: Philip surname: Hayward middlename: A fullname: Hayward, Philip A – sequence: 3 givenname: Jai surname: Raman fullname: Raman, Jai – sequence: 4 givenname: Simon surname: Moten middlename: C fullname: Moten, Simon C – sequence: 5 givenname: Alexander surname: Rosalion fullname: Rosalion, Alexander – sequence: 6 givenname: Ian surname: Gordon fullname: Gordon, Ian – sequence: 7 givenname: Siven surname: Seevanayagam fullname: Seevanayagam, Siven – sequence: 8 givenname: George surname: Matalanis fullname: Matalanis, George – sequence: 9 givenname: Umberto surname: Benedetto fullname: Benedetto, Umberto – sequence: 10 givenname: Mario surname: Gaudino fullname: Gaudino, Mario – sequence: 11 givenname: David surname: Hare middlename: L fullname: Hare, David L |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/33017209$$D View this record in MEDLINE/PubMed |
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ContentType | Journal Article |
Contributor | Doolan, Laurie Rowe, Michael Lim, Ruth O'Donnell, David McNicol, Larry Eng, John Brennan, John Fernando, Dharsh Smith, Gerard Jackson, Anthony Nadurata, Voltaire Horrigan, Mark Ecclestone, David Mehta, Nilesh Proimos, George Sylviris, Stephen Wellman, Chris Nadarajah, Nim Calafiore, Paul Gaer, Jullien Chan, Robert Sia, Ben Jones, Elizabeth Fabini, Robert Cotroneo, John Komeda, Masashi Tonkin, Anew Molan, Maurice Dortimer, Anthony Webb, Christopher Shaw, Margaret Johns, Jennifer Gerbo, Sana Clark, David Hameed, Irbaz Barlis, Peter Anaveker, Nagesh Farouque, Omar Kearney, Leighton Negri, Justin Bellomo, Rinaldo Oliver, Leslie Kertes, Paul Chan, Boniface Dick, Ronald |
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Copyright | 2020 by the American College of Cardiology Foundation and the American Heart Association, Inc. |
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References | 33017206 - Circulation. 2020 Oct 6;142(14):1339-1341 33872076 - Circulation. 2021 Apr 20;143(16):e832-e833 33872081 - Circulation. 2021 Apr 20;143(16):e834-e835 e_1_3_4_3_2 e_1_3_4_2_2 e_1_3_4_9_2 e_1_3_4_8_2 e_1_3_4_7_2 e_1_3_4_6_2 e_1_3_4_5_2 e_1_3_4_4_2 e_1_3_4_11_2 e_1_3_4_22_2 e_1_3_4_12_2 e_1_3_4_23_2 e_1_3_4_20_2 e_1_3_4_10_2 e_1_3_4_21_2 e_1_3_4_15_2 e_1_3_4_16_2 e_1_3_4_13_2 e_1_3_4_24_2 e_1_3_4_14_2 e_1_3_4_19_2 e_1_3_4_17_2 e_1_3_4_18_2 |
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Snippet | BACKGROUND:An internal thoracic artery graft to the left anterior descending artery is standard in coronary bypass surgery, but controversy exists on the best... An internal thoracic artery graft to the left anterior descending artery is standard in coronary bypass surgery, but controversy exists on the best second... Background: An internal thoracic artery graft to the left anterior descending artery is standard in coronary bypass surgery, but controversy exists on the best... BACKGROUNDAn internal thoracic artery graft to the left anterior descending artery is standard in coronary bypass surgery, but controversy exists on the best... |
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SubjectTerms | Adult Aged Coronary Artery Bypass Disease-Free Survival Female Humans Male Mammary Arteries Middle Aged Mortality Radial Artery Survival Rate Vascular Patency |
Title | Long-Term Results of the RAPCO Trials |
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