Effects of dopamine on posttraumatic cerebral blood flow, brain edema, and cerebrospinal fluid glutamate and hypoxanthine concentrations

• Published in: Critical care medicine Vol. 28; no. 12; p. 3792
• Main Authors: Kroppenstedt, S N, Stover, J F, Unterberg, A W
• Format: Journal Article
• Language: English
• Published: United States 01.12.2000
• Subjects: Animals; Blood Flow Velocity - drug effects; Blood Gas Analysis; Brain Edema - etiology; Brain Injuries - cerebrospinal fluid; Brain Injuries - complications; Brain Injuries - drug therapy; Brain Injuries - metabolism; Brain Injuries - physiopathology; Cardiotonic Agents - pharmacology; Cardiotonic Agents - therapeutic use; Cerebrospinal Fluid - chemistry; Cerebrospinal Fluid - drug effects; Cerebrovascular Circulation - drug effects; Disease Models, Animal; Dopamine - pharmacology; Dopamine - therapeutic use; Drug Evaluation, Preclinical; Glutamic Acid - analysis; Glutamic Acid - drug effects; Hypoxanthine - analysis; Laser-Doppler Flowmetry; Male; Random Allocation; Rats; Rats, Sprague-Dawley; Time Factors

Dopamine is often used in the treatment of traumatic brain injury to maintain cerebral perfusion pressure. However, it remains unclear whether dopamine contributes to secondary brain injury caused by vasoconstriction and resulting diminished cerebral perfusion. The present study investigated the eff...