Loss of hepatic DRP1 exacerbates alcoholic hepatitis by inducing megamitochondria and mitochondrial maladaptation

• Published in: Hepatology (Baltimore, Md.) Vol. 77; no. 1; pp. 159 - 175
• Main Authors: Ma, Xiaowen, Chen, Allen, Melo, Luma, Clemente-Sanchez, Ana, Chao, Xiaojuan, Ahmadi, Ali Reza, Peiffer, Brandon, Sun, Zhaoli, Sesaki, Hiromi, Li, Tiangang, Wang, Xiaokun, Liu, Wanqing, Bataller, Ramon, Ni, Hong-Min, Ding, Wen-Xing
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 01.01.2023
• Subjects: Animals; Ethanol - toxicity; Hepatitis, Alcoholic; Humans; Inflammation; Interferons; Liver Diseases, Alcoholic - metabolism; Mice; Mitochondria - metabolism; Mitochondrial Dynamics; Mitochondrial Swelling; Nucleotidyltransferases

Background and Aims: Increased megamitochondria formation and impaired mitophagy in hepatocytes have been linked to the pathogenesis of alcohol-associated liver disease (ALD). This study aims to determine the mechanisms by which alcohol consumption increases megamitochondria formation in the pathoge...