Mechanisms Behind the Pharmacological Application of Biochanin-A: A review [version 3; peer review: 2 approved]

This review was aimed at summarizing the cellular and molecular mechanisms behind the various pharmacological actions of biochanin-A. Many studies have been reported claiming its application in cancers, metabolic disorders, airway hyperresponsiveness, cardiac disorders, neurological disorders, etc....

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Published inF1000 research Vol. 12; p. 107
Main Authors Anuranjana, P.V., Beegum, Fathima, K.P, Divya, George, Krupa Thankam, Viswanatha, G.L., Nayak, Pawan G., Kanwal, Abhinav, Kishore, Anoop, Shenoy, Rekha R., Nandakumar, K.
Format Journal Article
LanguageEnglish
Published England Faculty of 1000 Ltd 2023
F1000 Research Limited
F1000 Research Ltd
Subjects
Bioavailability
Biochanin-A
Bone cancer
Breast
Breast cancer
Cancer
Cancer therapies
Cardiovascular system
Cell cycle
Clinical trials
Colon
Colorectal cancer
Diabetes
Diabetes mellitus
Drugs
eng
Enzymes
Flavonoids
Glioma
Hormone replacement therapy
Hyperlipidemia
Isoflavones
Leukemia
Lung cancer
Malignancy
Mechanism
Metabolic disorders
Metastasis
Molecular modelling
Molecular structure
Natural products
Neurological diseases
Neuroprotection
Osteosarcoma
Oxidative stress
Pancreatic cancer
Prostate
Prostate cancer
Red clover
Respiratory system
Review
Sarcoma
Soybeans
Trifolium pratense
Biochanin-A
Neuroprotection
Cardiovascular
Anti-oxidant
Diabetes
Mechanism
Isoflavones
Cancer
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Abstract This review was aimed at summarizing the cellular and molecular mechanisms behind the various pharmacological actions of biochanin-A. Many studies have been reported claiming its application in cancers, metabolic disorders, airway hyperresponsiveness, cardiac disorders, neurological disorders, etc. With regard to hormone-dependent cancers like breast, prostate, and other malignancies like pancreatic, colon, lung, osteosarcoma, glioma that has limited treatment options, biochanin-A revealed agreeable results in arresting cancer development. Biochanin-A has also shown therapeutic benefits when administered for neurological disorders, diabetes, hyperlipidaemia, and other chronic diseases/disorders. Isoflavones are considered phenomenal due to their high efficiency in modifying the physiological functions of the human body. Biochanin-A is one among the prominent isoflavones found in soy (glycine max), red clover (Trifolium pratense), and alfalfa sprouts, etc., with proven potency in modulating vital cellular mechanisms in various diseases. It has been popular for ages among menopausal women in controlling symptoms. In view of the multi-targeted functions of biochanin-A, it is essential to summarize it's mechanism of action in various disorders. The safety and efficacy of biochanin-A needs to be established in clinical trials involving human subjects. Biochanin-A might be able to modify various systems of the human body like the cardiovascular system, CNS, respiratory system, etc. It has shown a remarkable effect on hormonal cancers and other cancers. Many types of research on biochanin-A, particularly in breast, lung, colon, prostate, and pancreatic cancers, have shown a positive impact. Through modulating oxidative stress, SIRT-1 expression, PPAR gamma receptors, and other multiple mechanisms biochanin-A produces anti-diabetic action. The diverse molecular mechanistic pathways involved in the pharmacological ability of biochanin-A indicate that it is a very promising molecule and can play a major impact in modifying several physiological functions.
AbstractList This review was aimed at summarizing the cellular and molecular mechanisms behind the various pharmacological actions of biochanin-A. Many studies have been reported claiming its application in cancers, metabolic disorders, airway hyperresponsiveness, cardiac disorders, neurological disorders, etc. With regard to hormone-dependent cancers like breast, prostate, and other malignancies like pancreatic, colon, lung, osteosarcoma, glioma that has limited treatment options, biochanin-A revealed agreeable results in arresting cancer development. Biochanin-A has also shown therapeutic benefits when administered for neurological disorders, diabetes, hyperlipidaemia, and other chronic diseases/disorders. Isoflavones are considered phenomenal due to their high efficiency in modifying the physiological functions of the human body. Biochanin-A is one among the prominent isoflavones found in soy (glycine max), red clover (Trifolium pratense), and alfalfa sprouts, etc., with proven potency in modulating vital cellular mechanisms in various diseases. It has been popular for ages among menopausal women in controlling symptoms. In view of the multi-targeted functions of biochanin-A, it is essential to summarize it's mechanism of action in various disorders. The safety and efficacy of biochanin-A needs to be established in clinical trials involving human subjects. Biochanin-A might be able to modify various systems of the human body like the cardiovascular system, CNS, respiratory system, etc. It has shown a remarkable effect on hormonal cancers and other cancers. Many types of research on biochanin-A, particularly in breast, lung, colon, prostate, and pancreatic cancers, have shown a positive impact. Through modulating oxidative stress, SIRT-1 expression, PPAR gamma receptors, and other multiple mechanisms biochanin-A produces anti-diabetic action. The diverse molecular mechanistic pathways involved in the pharmacological ability of biochanin-A indicate that it is a very promising molecule and can play a major impact in modifying several physiological functions.
This review was aimed at summarizing the cellular and molecular mechanisms behind the various pharmacological actions of biochanin-A. Many studies have been reported claiming its application in cancers, metabolic disorders, airway hyperresponsiveness, cardiac disorders, neurological disorders, etc. With regard to hormone-dependent cancers like breast, prostate, and other malignancies like pancreatic, colon, lung, osteosarcoma, glioma that has limited treatment options, biochanin-A revealed agreeable results in arresting cancer development. Biochanin-A has also shown therapeutic benefits when administered for neurological disorders, diabetes, hyperlipidaemia, and other chronic diseases/disorders. Isoflavones are considered phenomenal due to their high efficiency in modifying the physiological functions of the human body. Biochanin-A is one among the prominent isoflavones found in soy (glycine max), red clover (Trifolium pratense), and alfalfa sprouts, etc., with proven potency in modulating vital cellular mechanisms in various diseases. It has been popular for ages among menopausal women in controlling symptoms. In view of the multi-targeted functions of biochanin-A, it is essential to summarize it's mechanism of action in various disorders. The safety and efficacy of biochanin-A needs to be established in clinical trials involving human subjects. Biochanin-A might be able to modify various systems of the human body like the cardiovascular system, CNS, respiratory system, etc. It has shown a remarkable effect on hormonal cancers and other cancers. Many types of research on biochanin-A, particularly in breast, lung, colon, prostate, and pancreatic cancers, have shown a positive impact. Through modulating oxidative stress, SIRT-1 expression, PPAR gamma receptors, and other multiple mechanisms biochanin-A produces anti-diabetic action. The diverse molecular mechanistic pathways involved in the pharmacological ability of biochanin-A indicate that it is a very promising molecule and can play a major impact in modifying several physiological functions.This review was aimed at summarizing the cellular and molecular mechanisms behind the various pharmacological actions of biochanin-A. Many studies have been reported claiming its application in cancers, metabolic disorders, airway hyperresponsiveness, cardiac disorders, neurological disorders, etc. With regard to hormone-dependent cancers like breast, prostate, and other malignancies like pancreatic, colon, lung, osteosarcoma, glioma that has limited treatment options, biochanin-A revealed agreeable results in arresting cancer development. Biochanin-A has also shown therapeutic benefits when administered for neurological disorders, diabetes, hyperlipidaemia, and other chronic diseases/disorders. Isoflavones are considered phenomenal due to their high efficiency in modifying the physiological functions of the human body. Biochanin-A is one among the prominent isoflavones found in soy (glycine max), red clover (Trifolium pratense), and alfalfa sprouts, etc., with proven potency in modulating vital cellular mechanisms in various diseases. It has been popular for ages among menopausal women in controlling symptoms. In view of the multi-targeted functions of biochanin-A, it is essential to summarize it's mechanism of action in various disorders. The safety and efficacy of biochanin-A needs to be established in clinical trials involving human subjects. Biochanin-A might be able to modify various systems of the human body like the cardiovascular system, CNS, respiratory system, etc. It has shown a remarkable effect on hormonal cancers and other cancers. Many types of research on biochanin-A, particularly in breast, lung, colon, prostate, and pancreatic cancers, have shown a positive impact. Through modulating oxidative stress, SIRT-1 expression, PPAR gamma receptors, and other multiple mechanisms biochanin-A produces anti-diabetic action. The diverse molecular mechanistic pathways involved in the pharmacological ability of biochanin-A indicate that it is a very promising molecule and can play a major impact in modifying several physiological functions.
Author Nandakumar, K.
Nayak, Pawan G.
Beegum, Fathima
K.P, Divya
Anuranjana, P.V.
George, Krupa Thankam
Kanwal, Abhinav
Kishore, Anoop
Shenoy, Rekha R.
Viswanatha, G.L.
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– sequence: 7
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  surname: Kanwal
  fullname: Kanwal, Abhinav
  organization: Department of Pharmacology, All India Institute of Medical Sciences, Bathinda, Punjab, India
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  givenname: Anoop
  orcidid: 0000-0002-8116-8408
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  organization: Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India
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  organization: Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India
BackLink https://www.ncbi.nlm.nih.gov/pubmed/38106650$$D View this record in MEDLINE/PubMed
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ContentType Journal Article
Copyright Copyright: © 2023 Anuranjana PV et al.
Copyright: © 2023 Anuranjana PV et al. This work is published under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Copyright: © 2023 Anuranjana PV et al. 2023
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Keywords Biochanin-A
Neuroprotection
Cardiovascular
Anti-oxidant
Diabetes
Mechanism
Isoflavones
Cancer
Language English
License http://creativecommons.org/licenses/by/4.0/: This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright: © 2023 Anuranjana PV et al.
This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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No competing interests were disclosed.
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Snippet This review was aimed at summarizing the cellular and molecular mechanisms behind the various pharmacological actions of biochanin-A. Many studies have been...
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SubjectTerms Bioavailability
Biochanin-A
Bone cancer
Breast
Breast cancer
Cancer
Cancer therapies
Cardiovascular system
Cell cycle
Clinical trials
Colon
Colorectal cancer
Diabetes
Diabetes mellitus
Drugs
eng
Enzymes
Flavonoids
Glioma
Hormone replacement therapy
Hyperlipidemia
Isoflavones
Leukemia
Lung cancer
Malignancy
Mechanism
Metabolic disorders
Metastasis
Molecular modelling
Molecular structure
Natural products
Neurological diseases
Neuroprotection
Osteosarcoma
Oxidative stress
Pancreatic cancer
Prostate
Prostate cancer
Red clover
Respiratory system
Review
Sarcoma
Soybeans
Trifolium pratense
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Title Mechanisms Behind the Pharmacological Application of Biochanin-A: A review [version 3; peer review: 2 approved]
URI http://dx.doi.org/10.12688/f1000research.126059.3
https://www.ncbi.nlm.nih.gov/pubmed/38106650
https://www.proquest.com/docview/2908080859
https://www.proquest.com/docview/2903327442
https://pubmed.ncbi.nlm.nih.gov/PMC10725524
https://doaj.org/article/6e9fff294f91448d8ad02abf2a670188
Volume 12
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