High-fat diet exacerbates postoperative pain and inflammation in a sex-dependent manner

• Published in: Pain (Amsterdam) Vol. 159; no. 9; pp. 1731 - 1741
• Main Authors: Song, Zongbin, Xie, Wenrui, Strong, Judith A., Berta, Temugin, Ulrich-Lai, Yvonne M., Guo, Qulian, Zhang, Jun-Ming
• Format: Journal Article
• Language: English
• Published: United States Wolters Kluwer 01.09.2018
• Subjects: Animals; Behavior, Animal - physiology; Diet, High-Fat - adverse effects; Energy Intake - physiology; Female; GAP-43 Protein - metabolism; Inflammation - etiology; Inflammation - metabolism; Macrophages, Peritoneal - metabolism; Male; Pain, Postoperative - etiology; Pain, Postoperative - metabolism; Rats; Rats, Long-Evans; Sex Factors; Wound Healing - physiology

Obesity is often associated with increased pain, but little is known about the effects of obesity and diet on postoperative pain. In this study, effects of diet and obesity were examined in the paw incision model, a preclinical model of postoperative pain. Long–Evans rats were fed high-fat diet (40%...