Production of Feline Universal Erythrocytes with Methoxy Polyethylene Glycol
Blood group mismatch in veterinary medicine is a significant problem in blood transfusion, sometimes leading to severe transfusion reactions and even patient death. Blood groups vary from species to species and there are three known blood groups in cats: A, B and AB. While A-type cats are most commo...
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Published in | Journal of functional biomaterials Vol. 14; no. 9; p. 476 |
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Format | Journal Article |
Language | English |
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01.09.2023
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Abstract | Blood group mismatch in veterinary medicine is a significant problem in blood transfusion, sometimes leading to severe transfusion reactions and even patient death. Blood groups vary from species to species and there are three known blood groups in cats: A, B and AB. While A-type cats are most common, there is a shortage of feline B-type blood groups in cats. By using methoxy polyethylene glycol (mPEG) to protect antigenic epitopes on red blood cells (RBCs), we aimed to find the optimal conditions for the production of feline universal RBCs. The surfaces of feline A-type RBCs were treated with mPEG at various molecular weights and concentrations. Agglutination tests showed that the coating of feline A-type RBCs with mPEG of 20 kDa and 2 mM blocked hemagglutination to feline anti-A alloantibodies over 8 h. While no differences in RBC size and shape between intact and mPEG-treated RBCs were seen, coating RBCs with mPEG inhibited the binding of feline anti-A alloantibodies. Furthermore, the mPEG-treated RBCs did not cause spontaneous hemolysis or osmotic fragility, compared to control RBCs. According to a monocyte monolayer assay, mPEG treatment significantly reduced feline anti-A antibody-mediated phagocystosis of RBCs. These results confirm the potential of using activated mPEG on feline A-type RBC to create universal erythrocytes for transfusion to B-type cats. |
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AbstractList | Blood group mismatch in veterinary medicine is a significant problem in blood transfusion, sometimes leading to severe transfusion reactions and even patient death. Blood groups vary from species to species and there are three known blood groups in cats: A, B and AB. While A-type cats are most common, there is a shortage of feline B-type blood groups in cats. By using methoxy polyethylene glycol (mPEG) to protect antigenic epitopes on red blood cells (RBCs), we aimed to find the optimal conditions for the production of feline universal RBCs. The surfaces of feline A-type RBCs were treated with mPEG at various molecular weights and concentrations. Agglutination tests showed that the coating of feline A-type RBCs with mPEG of 20 kDa and 2 mM blocked hemagglutination to feline anti-A alloantibodies over 8 h. While no differences in RBC size and shape between intact and mPEG-treated RBCs were seen, coating RBCs with mPEG inhibited the binding of feline anti-A alloantibodies. Furthermore, the mPEG-treated RBCs did not cause spontaneous hemolysis or osmotic fragility, compared to control RBCs. According to a monocyte monolayer assay, mPEG treatment significantly reduced feline anti-A antibody-mediated phagocystosis of RBCs. These results confirm the potential of using activated mPEG on feline A-type RBC to create universal erythrocytes for transfusion to B-type cats. |
Audience | Academic |
Author | Yoon, Joo Won Jang, Han Byeol Lee, Dong Min Ma, Jing Kim, Hee Young Xing, Juping Lee, Kyung Hee Ahn, Dan Bi Kim, Chang Hyun Kim, Hyung Kyu |
AuthorAffiliation | 1 Department of Physiology, Yonsei University College of Medicine, Seoul 03722, Republic of Korea; badawanabi@knu.ac.kr (H.K.K.); anda1434@yuhs.ac (D.B.A.); star961018@naver.com (H.B.J.); majing981018@naver.com (J.M.); xingjuping@yonsei.ac.kr (J.X.); joowonyoon77@gmail.com (J.W.Y.) 2 Department of Oral Physiology, School of Dentistry, Kyungpook National University, Daegu 41940, Republic of Korea 3 KABB, Daegu 42212, Republic of Korea; lkh277@hanmail.net (K.H.L.); mutalisk2@naver.com (D.M.L.); agoni@naver.com (C.H.K.) |
AuthorAffiliation_xml | – name: 3 KABB, Daegu 42212, Republic of Korea; lkh277@hanmail.net (K.H.L.); mutalisk2@naver.com (D.M.L.); agoni@naver.com (C.H.K.) – name: 2 Department of Oral Physiology, School of Dentistry, Kyungpook National University, Daegu 41940, Republic of Korea – name: 1 Department of Physiology, Yonsei University College of Medicine, Seoul 03722, Republic of Korea; badawanabi@knu.ac.kr (H.K.K.); anda1434@yuhs.ac (D.B.A.); star961018@naver.com (H.B.J.); majing981018@naver.com (J.M.); xingjuping@yonsei.ac.kr (J.X.); joowonyoon77@gmail.com (J.W.Y.) |
Author_xml | – sequence: 1 givenname: Hyung Kyu surname: Kim fullname: Kim, Hyung Kyu – sequence: 2 givenname: Dan Bi surname: Ahn fullname: Ahn, Dan Bi – sequence: 3 givenname: Han Byeol surname: Jang fullname: Jang, Han Byeol – sequence: 4 givenname: Jing surname: Ma fullname: Ma, Jing – sequence: 5 givenname: Juping surname: Xing fullname: Xing, Juping – sequence: 6 givenname: Joo Won surname: Yoon fullname: Yoon, Joo Won – sequence: 7 givenname: Kyung Hee surname: Lee fullname: Lee, Kyung Hee – sequence: 8 givenname: Dong Min surname: Lee fullname: Lee, Dong Min – sequence: 9 givenname: Chang Hyun surname: Kim fullname: Kim, Chang Hyun – sequence: 10 givenname: Hee Young surname: Kim fullname: Kim, Hee Young |
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Cites_doi | 10.1016/S0195-5616(95)50157-3 10.1111/vec.12937 10.1016/j.tracli.2003.12.005 10.1016/j.tox.2005.06.001 10.1159/000357986 10.1016/j.biomaterials.2010.01.137 10.1073/pnas.94.14.7566 10.3389/fvets.2020.00085 10.1002/ajh.24211 10.1111/j.1423-0410.1989.tb01152.x 10.1111/j.1939-1676.2007.tb02962.x 10.3390/ani11123339 10.1016/j.tmrv.2004.06.005 10.1016/j.actbio.2010.01.031 10.1016/j.transproceed.2006.02.068 10.1016/j.exphem.2016.11.001 10.1111/j.1939-1676.2007.tb02961.x 10.1111/vec.13044 10.1016/j.biomaterials.2013.09.016 10.1053/j.ctsap.2004.01.005 10.1182/blood.V93.6.2121.406a30_2121_2127 10.1111/tme.12189 10.1053/jfms.2001.0162 10.1111/j.1365-3148.2010.01054.x |
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Snippet | Blood group mismatch in veterinary medicine is a significant problem in blood transfusion, sometimes leading to severe transfusion reactions and even patient... |
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SubjectTerms | Agglutination Alloantibodies Antibodies Antigenic determinants Antigens Blood groups Blood transfusion Blood transfusions Cats Epitopes Erythrocytes feline Fragility Hemagglutination Hemoglobin Laboratory animals Molecular weight Monocytes Morphology mPEG MPEG encoders Polyethylene glycol RBC Transfusion universal red blood cells Variance analysis Veterinary medicine Viral antibodies |
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Title | Production of Feline Universal Erythrocytes with Methoxy Polyethylene Glycol |
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