Molecular Chaperones and Proteolytic Machineries Regulate Protein Homeostasis in Aging Cells

• Published in: Cells (Basel, Switzerland) Vol. 9; no. 5; p. 1308
• Main Authors: Margulis, Boris, Tsimokha, Anna, Zubova, Svetlana, Guzhova, Irina
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 24.05.2020; MDPI
• Subjects: Age; Aging; Animals; Autophagy; Cell death; Cell growth; Cell survival; Cellular Senescence; Chaperones; Cooperativity; Degeneration; Disease; Endoplasmic reticulum; Fibroblasts; Heat shock proteins; Homeostasis; Humans; Kinases; Life cycles; Models, Biological; molecular chaperones; Molecular Chaperones - metabolism; Nematodes; Oxidative stress; Phagocytosis; Polypeptides; Proteasomes; Protein biosynthesis; Protein synthesis; Protein transport; Proteolysis; Proteostasis; Review; Senescence; Stress response; Ubiquitin; ubiquitin-proteasomal system; autophagy; aging; molecular chaperones; ubiquitin-proteasomal system

Throughout their life cycles, cells are subject to a variety of stresses that lead to a compromise between cell death and survival. Survival is partially provided by the cell proteostasis network, which consists of molecular chaperones, a ubiquitin-proteasome system of degradation and autophagy. The...